Search Results - "TOLKACHEVA, Elena"

Mechanisms of arrhythmia termination during acute myocardial ischemia: Role of ephaptic coupling and complex geometry of border zone by Wei, Ning, Tolkacheva, Elena G

“…Myocardial ischemia occurs when blood flow to the heart is reduced, preventing the heart muscle from receiving enough oxygen required for survival. Several…”
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In Situ Expansion, Differentiation, and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid by Kupfer, Molly E., Lin, Wei-Han, Ravikumar, Vasanth, Qiu, Kaiyan, Wang, Lu, Gao, Ling, Bhuiyan, Didarul B., Lenz, Megan, Ai, Jeffrey, Mahutga, Ryan R., Townsend, DeWayne, Zhang, Jianyi, McAlpine, Michael C., Tolkacheva, Elena G., Ogle, Brenda M.

“…One goal of cardiac tissue engineering is the generation of a living, human pump in vitro that could replace animal models and eventually serve as an in vivo…”
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Complexity AF score as a novel marker of atrial fibrillation instability by Lee, Jieun, Brower, Autumn J., Roukoz, Henri, Tolkacheva, Elena G.

“…Atrial fibrillation (AF) is a heart disease affecting millions of Americans. Clinicians evaluate AF-related risk by assessing the temporal pattern, variation,…”
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Interplay between ephaptic coupling and complex geometry of border zone during acute myocardial ischemia: Effect on arrhythmogeneity by Wei, Ning, Tolkacheva, Elena G

“…Acute myocardial ischemia is an imbalance between myocardial blood supply and demand, which is caused by the cessation of blood flow within the heart resulting…”
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The dual effect of ephaptic coupling on cardiac conduction with heterogeneous expression of connexin 43 by Wei, Ning, Mori, Yoichiro, Tolkacheva, Elena G.

“…Decreased and heterogeneous expression of connexin 43 (Cx43) are common features in animal heart failure models. Ephpatic coupling, which relies on the…”
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Editorial: Non-linear analysis and machine learning in cardiology by Dierckx, Hans, Zhao, Xiaopeng, Tolkacheva, Elena G

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Dynamics study of constant diastolic interval and constant TR control for cardiac alternans based on a two-dimensional cellular automata model by Xiong, Min, Sun, Kai, Su, Xiaowen, Tolkacheva, Elena G., Zhao, Xiaopeng

“…As a precursor for cardiac arrhythmias such as atrial and ventricular fibrillations, which could cause sudden cardiac death, cardiac alternans is essentially…”
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A Data-Driven Preprocessing Framework for Atrial Fibrillation Intracardiac Electrocardiogram Analysis by Kong, Xiangzhen, Ravikumar, Vasanth, Mulpuru, Siva K, Roukoz, Henri, Tolkacheva, Elena G

“…Atrial Fibrillation (AF) is the most common cardiac arrhythmia. Signal-processing approaches are widely used for the analysis of intracardiac electrograms…”
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Image-Decomposition-Enhanced Deep Learning for Detection of Rotor Cores in Cardiac Fibrillation by Shu, Yu, Smith, Tianqi Gao, Arunachalam, Shivaram P., Tolkacheva, Elena G., Cheng, Changqing

“…Objective: Rotors, regions of spiral wave reentry in cardiac tissues, are considered as the drivers of atrial fibrillation (AF), the most common arrhythmia…”
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Architectural Considerations in the Design of a Superconducting Quantum Annealing Processor by Bunyk, P. I., Hoskinson, Emile M., Johnson, Mark W., Tolkacheva, Elena, Altomare, Fabio, Berkley, Andrew J., Harris, Richard, Hilton, Jeremy P., Lanting, Trevor, Przybysz, Anthony J., Whittaker, Jed

“…We have developed a quantum annealing processor, based on an array of tunable coupled rf-SQUID flux qubits, fabricated in a superconducting integrated circuit…”
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Real-Time Closed Loop Diastolic Interval Control Prevents Cardiac Alternans in Isolated Whole Rabbit Hearts by Kulkarni, Kanchan, Lee, Steven W., Kluck, Ryan, Tolkacheva, Elena G.

“…Cardiac alternans, a beat-to-beat alternation in action potential duration ( APD ), can lead to fatal arrhythmias. During periodic pacing, changes in diastolic…”
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Novel mapping techniques for rotor core detection using simulated intracardiac electrograms by Ravikumar, Vasanth, Annoni, Elizabeth, Parthiban, Preethy, Zlochiver, Sharon, Roukoz, Henri, Mulpuru, Siva K., Tolkacheva, Elena G.

“…Background Catheter ablation is associated with limited success rates in patients with persistent atrial fibrillation (AF). Currently, existing mapping systems…”
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Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction by Liu, Man, Liu, Hong, Parthiban, Preethy, Kang, Gyeoung-Jin, Shi, Guangbin, Feng, Feng, Zhou, Anyu, Gu, Lianzhi, Karnopp, Courtney, Tolkacheva, Elena G, Dudley, Jr, Samuel C

“…Ischemic cardiomyopathy is associated with an increased risk of sudden death, activation of the unfolded protein response (UPR), and reductions in multiple…”
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Proliferation and Maturation: Janus and the Art of Cardiac Tissue Engineering by Singh, Bhairab N., Yucel, Dogacan, Garay, Bayardo I., Tolkacheva, Elena G., Kyba, Michael, Perlingeiro, Rita C.R., van Berlo, Jop H., Ogle, Brenda M.

“…During cardiac development and morphogenesis, cardiac progenitor cells differentiate into cardiomyocytes that expand in number and size to generate the fully…”
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Atherosclerotic Calcifications Have a Local Effect on the Peel Behavior of Human Aortic Media by Donahue, Carly L, Badal, Ruturaj M, Younger, Thomas S, Guan, Weihua, Tolkacheva, Elena G, Barocas, Victor H

“…Aortic dissections, characterized by the propagation of a tear through the layers of the vessel wall, are critical, life-threatening events. Aortic…”
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Similarity Score for the Identification of Active Sites in Patients With Atrial Fibrillation by Ravikumar, Vasanth, Thakare, Sanket, Kong, Xiangzhen, Roukoz, Henri, Tolkacheva, Elena G

“…Atrial fibrillation (AF) is the most common cardiac arrhythmia and precursor to other cardiac diseases. Catheter ablation is associated with limited success…”
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The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart by Kulkarni, Kanchan, Xie, Xueyi, Marron Fernandez de Velasco, Ezequiel, Anderson, Allison, Martemyanov, Kirill A, Wickman, Kevin, Tolkacheva, Elena G

“…A large body of work has established the prominent roles of the atrial M2R-IKACh signaling pathway, and the negative regulatory protein RGS6, in modulating…”
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Role of Conduction Velocity Restitution and Short-Term Memory in the Development of Action Potential Duration Alternans in Isolated Rabbit Hearts by MIRONOV, Sergey, JALIFE, José, TOLKACHEVA, Elena G

“…Spatially discordant alternans (SDA) has been linked to life-threatening arrhythmias. The mechanisms underlying SDA development in cardiac tissue remain…”
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A Bionic Testbed for Cardiac Ablation Tools by Lin, Wei-Han, Zhu, Zhijie, Ravikumar, Vasanth, Sharma, Vinod, Tolkacheva, Elena G, McAlpine, Michael C, Ogle, Brenda M

“…Bionic-engineered tissues have been proposed for testing the performance of cardiovascular medical devices and predicting clinical outcomes ex vivo. Progress…”
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A Phase Defect Framework for the Analysis of Cardiac Arrhythmia Patterns by Arno, Louise, Quan, Jan, Nguyen, Nhan T., Vanmarcke, Maarten, Tolkacheva, Elena G., Dierckx, Hans

“…During cardiac arrhythmias, dynamical patterns of electrical activation form and evolve, which are of interest to understand and cure heart rhythm disorders…”
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