Search Results - "TOKUMARU, Yutaka"

Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma by Habu, Noboru, Imanishi, Yorihisa, Kameyama, Kaori, Shimoda, Masayuki, Tokumaru, Yutaka, Sakamoto, Koji, Fujii, Ryoichi, Shigetomi, Seiji, Otsuka, Kuninori, Sato, Yoichiro, Watanabe, Yoshihiro, Ozawa, Hiroyuki, Tomita, Toshiki, Fujii, Masato, Ogawa, Kaoru

“…The side population (SP) of cancer cells is reportedly enriched with cancer stem cells (CSCs), however, the functional role and clinical relevance of CSC…”
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Prevalence of human papillomavirus in oropharyngeal cancer: a multicenter study in Japan by Hama, Takanori, Tokumaru, Yutaka, Fujii, Masato, Yane, Katsunari, Okami, Kenji, Kato, Kengo, Masuda, Muneyuki, Mineta, Hiroyuki, Nakashima, Torahiko, Sugasawa, Masashi, Sakihama, Noriyuki, Yoshizaki, Tomokazu, Hanazawa, Toyoyuki, Kato, Hisayuki, Hirano, Shigeru, Imanishi, Yorihisa, Kuratomi, Yuichirou, Otsuki, Naoki, Ota, Ichiro, Sugimoto, Taro, Suzuki, Shinsuke

“…The incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) have risen steadily in the USA and in northern Europe. These increases are thought to be a…”
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Evaluation of Promoter Hypermethylation Detection in Body Fluids as a Screening/Diagnosis Tool for Head and Neck Squamous Cell Carcinoma by CARVALHO, André Lopes, JERONIMO, Carmen, CLAYBOURNE, Quia, TOKUMARU, Yutaka, LEE, Juna, GOLDENBERG, David, GARRETT-MAYER, Elizabeth, GOODMAN, Steven, MOON, Chul-So, KOCH, Wayne, WESTRA, William H, SIDRANSKY, David, KIM, Michael M, CALIFANO, Joseph A, HENRIQUE, Rui, ZHE ZHANG, HOQUE, Mohammad O, CHANG, Steve, BRAIT, Mariana, NAYAK, Chetan S, JIANG, Wei-Wen

“…Purpose: To evaluate aberrant promoter hypermethylation of candidate tumor suppressor genes as a means to detect epigenetic alterations specific to solid…”
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The role of PGP9.5 as a tumor suppressor gene in human cancer by Tokumaru, Yutaka, Yamashita, Keishi, Kim, Myoung Sook, Park, Hannah L., Osada, Motonobu, Mori, Masaki, Sidransky, David

“…PGP9.5 is a controversial molecule from an oncologic point of view. We recently identified frequent methylation of PGP9.5 gene exclusively in primary head and…”
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Detection of Promoter Hypermethylation of Multiple Genes in the Tumor and Bronchoalveolar Lavage of Patients with Lung Cancer by TOPALOGLU, Ozlem, HOQUE, Mohammad Obaidul, TOKUMARU, Yutaka, LEE, Juna, RATOVITSKI, Edward, SIDRANSKY, David, MOON, Chul-So

“…Purpose: Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of lung cancers and…”
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Independent exercise for glottal incompetence to improve vocal problems and prevent aspiration pneumonia in the elderly: a randomized controlled trial by Fujimaki, Yoko, Tsunoda, Koichi, Kobayashi, Rika, Tonghyo, Chong, Tanaka, Fujinobu, Kuroda, Hiroyuki, Numata, Tsutomu, Ishii, Toyota, Kuroda, Reiko, Masuda, Sawako, Hashimoto, Sho, Misawa, Hayato, Shindo, Naoko, Mori, Takahiro, Mori, Hiroko, Uchiyama, Naoki, Kamei, Yuichirou, Tanaka, Masashi, Hamaya, Hironobu, Funatsuki, Shingo, Usui, Satoko, Ito, Ikuno, Hamada, Kohei, Shindo, Akihito, Tokumaru, Yutaka, Morita, Yoko, Ueha, Rumi, Nito, Takaharu, Kikuta, Shu, Sekimoto, Sotaro, Kondo, Kenji, Sakamoto, Takashi, Itoh, Kenji, Yamasoba, Tatsuya, Matsumoto, Sumio

“…Objectives: To evaluate the effect of a self-controlled vocal exercise in elderly people with glottal closure insufficiency. Design: Parallel-arm, individual…”
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Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell Cancer by Baba, Yuh, Fujii, Masato, Tokumaru, Yutaka, Kato, Yasumasa

“…Although EGFR is expressed at high levels in head and neck squamous cell carcinomas (HNSCCs) and mutations are extremely rare, monotherapy with EGFR inhibitors…”
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PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma by MANDELKER, Diana L, YAMASHITA, Keishi, OSADA, Motonobu, MORI, Masaki, SIDRANSKY, David, TOKUMARU, Yutaka, MIMORI, Koshi, HOWARD, David L, TANAKA, Yoichi, LOPES CARVALHO, Andre, JIANG, Wei-Wen, HANNAH LUI PARK, MYOUNG SOOK KIM

“…PGP9.5/UCHL1 is a member of the carboxyl-terminal ubiquitin hydrolase family with a potential role in carcinogenesis. We previously identified PGP9.5 as a…”
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Gene Promoter Hypermethylation in Tumors and Lymph Nodes of Stage I Lung Cancer Patients by HARDEN, Susan V, TOKUMARU, Yutaka, WESTRA, William H, GOODMAN, Steven, AHRENDT, Steven A, YANG, Stephen C, SIDRANSKY, David

“…Promoter hypermethylation is an important pathway for repression of gene transcription in cancer cells and a promising marker for cancer detection. We tested…”
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Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing by TOKUMARU, Yutaka, YAMASHITA, Keishi, OSADA, Motonobu, NOMOTO, Shuji, SUN, Dong-Il, YAN XIAO, MOHAMMAD OBAIDUL HOQUE, WESTRA, William H, CALIFANO, Joseph A, SIDRANSKY, David

“…Aberrant promoter hypermethylation of tumor suppressor genes is proposed to be a common feature of primary cancer cells. We recently developed a…”
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Large cell neuroendocrine carcinoma of the submandibular gland: Case report and literature review by Yamamoto, Nobuko, Minami, Shujiro, Kidoguchi, Masanori, Shindo, Akihito, Tokumaru, Yutaka, Fujii, Masato

“…Abstract Large cell neuroendocrine carcinoma (LCNEC) of the salivary gland is extremely rare. We report on a case of LCNEC in the submandibular gland. A…”
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HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma by Yamashita, Keishi, Kim, Myoung Sook, Park, Hannah Lui, Tokumaru, Yutaka, Osada, Motonobu, Inoue, Hiroshi, Mori, Masaki, Sidransky, David

“…Promoter DNA hypermethylation with gene silencing is a common feature of human cancer, and cancer-prone methylation is believed to be a landmark of tumor…”
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PGP9.5 methylation in diffuse-type gastric cancer by YAMASHITA, Keishi, HANNAH LUI PARK, MYOUNG SOOK KIM, OSADA, Motonobu, TOKUMARU, Yutaka, INOUE, Hiroshi, MORI, Masaki, SIDRANSKY, David

“…Diffuse-type gastric cancer (DGC) is the most deadly form of gastric cancer and is frequently accompanied by peritoneal dissemination and metastasis. The…”
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Optimal Use of a Panel of Methylation Markers with GSTP1 Hypermethylation in the Diagnosis of Prostate Adenocarcinoma by TOKUMARU, Yutaka, HARDEN, Susan V, SUN, Dong-Il, YAMASHITA, Keishi, EPSTEIN, Jonathan I, SIDRANSKY, David

“…Purpose: In this study, we tested the ability of a panel of hypermethylation markers to improve the sensitivity of histologic prostate cancer detection in…”
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Common but Critical Sensation in Older Adults by Suto, Yuumi, Tsunoda, Koichi, Chong, Tonghyo, Morita, Yohko, Nakamura, Yoshiki, Isobe, Yoshinori, Tokumaru, Yutaka, Bito, Seiji

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Biallelic inactivation of the RIZ1 gene in human gastric cancer by TOKUMARU, Yutaka, NOMOTO, Shuji, JERONIMO, Carmen, HENRIQUE, Rui, HARDEN, Susan, TRINK, Barry, SIDRANSKY, David

“…The distal short arm of chromosome 1 is commonly deleted in a variety of human neoplasms including gastrointestinal cancer. Genetic alterations of the…”
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Decreased Expression of Connexin-30 and Aberrant Expression of Connexin-26 in Human Head and Neck Cancer by OZAWA, Hiroyuki, MATSUNAGA, Tatsuo, KAMIYA, Kazusaku, TOKUMARU, Yutaka, FUJII, Masato, TOMITA, Toshiki, OGAWA, Kaoru

“…Background: The relation of connexins and carcinogenesis has been studied in various organs and cell lines, with connexins currently being considered tumor…”
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A Promoter Methylation Pattern in the N-Methyl-d-Aspartate Receptor 2B Gene Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma by MYOUNG SOOK KIM, YAMASHITA, Keishi, SIDRANSKY, David, YOUNG KWANG CHAE, TOKUMARU, Yutaka, XIAOFEI CHANG, ZAHURAK, Marianna, OSADA, Motonobu, HANNAH LUI PARK, CHUANG, Alice, CALIFANO, Joseph A

“…Purpose: To investigate whether the promoter methylation pattern in N -methyl- d -aspartate receptor 2B (NMDAR2B) is correlated with clinical features of human…”
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Promoted Cell Proliferation by Connexin 30 Gene Transfection to Head-and-Neck Cancer Cell Line by OZAWA, Hiroyuki, MUTAI, Hideki, MATSUNAGA, Tatsuo, TOKUMARU, Yutaka, FUJII, Masato, SAKAMOTO, Kouji, TOMITA, Toshiki, OGAWA, Kaoru

“…Background: There have been inconsistent results regarding the contribution of the connexin family of genes to tumor cell proliferation. Materials and Methods:…”
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Detecting Cervical Cancer by Quantitative Promoter Hypermethylation Assay on Cervical Scrapings: A Feasibility Study by Reesink-Peters, Nathalie, Wisman, G Bea A, Jéronimo, Carmen, Tokumaru, C Yutaka, Cohen, Yoram, Dong, Seung Myung, Klip, Harrie G, Buikema, Henk J, Suurmeijer, Albert J H, Hollema, Harrie, Boezen, H Marieke, Sidransky, David, van der Zee, Ate G J

“…Current morphology-based cervical cancer screening is associated with significant false-positive and false-negative results. Tumor suppressor gene…”
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