Search Results - "TJUVAJEV, Juri G"

Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes by O'Reilly, Richard J, Koehne, Guenther, Doubrovin, Mikhail, Doubrovina, Ekaterina, Zanzonico, Pat, Gallardo, Humilidad F, Ivanova, Anna, Balatoni, Julius, Teruya-Feldstein, Julie, Heller, Glenn, May, Chad, Ponomarev, Vladimir, Ruan, Shutian, Finn, Ronald, Blasberg, Ronald G, Bornmann, William, Riviere, Isabelle, Sadelain, Michel, Larson, Steven M, Gelovani Tjuvajev, Juri G

“…New technologies are needed to characterize the migration, survival, and function of antigen-specific T cells in vivo. Here, we demonstrate that Epstein-Barr…”
Get full text

Functional Coexpression of HSV-1 Thymidine Kinase and Green Fluorescent Protein: Implications for Noninvasive Imaging of Transgene Expression by Jacobs, Andreas, Dubrovin, Michael, Hewett, Jeff, Sena-Esteves, Miguel, Tan, Cui-Wen, Slack, Mark, Sadelain, Michele, Breakefield, Xandra O., Tjuvajev, Juri G.

“…Current gene therapy technology is limited by the paucity of methodology for determining the location and magnitude of therapeutic transgene expression in…”
Get full text

Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography by TJUVAJEV, J. G, AVRIL, N, AUGENSEN, F, KOUTCHER, J, ZWEIT, J, HUMM, J, LARSON, S. M, FINN, R, BLASBERG, R, OKU, T, SASAJIMA, T, MIYAGAWA, T, JOSHI, R, SAFER, M, BEATTIE, B, DIRESTA, G, DAGHIGHIAN, F

“…We report a series of studies that assess the feasibility and sensitivity of imaging of herpes virus type one thymidine kinase (HSV1-tk) gene transfer and…”
Get full text

Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo by JACOBS, Andreas, TJUVAJEV, Juri G, PECHAN, Peter A, CHIOCCA, E. Antonio, BREAKEFIELD, Xandra O, BLASBERG, Ronald G, DUBROVIN, Michael, AKHURST, Timothy, BALATONI, Julius, BEATTI, Bradley, JOSHI, Revathi, FINN, Ronald, LARSON, Steven M, HERRLINGER, Ulrich

“…To evaluate the efficiency of gene delivery in gene therapy strategies for malignant brain tumors, it is important to determine the distribution and magnitude…”
Get full text

Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy by Tjuvajev, J G, Finn, R, Watanabe, K, Joshi, R, Oku, T, Kennedy, J, Beattie, B, Koutcher, J, Larson, S, Blasberg, R G

“…Noninvasive imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression is possible with a clinical gamma camera and by single-photon…”
Get full text

Imaging the expression of transfected genes in vivo by TJUVAJEV, J. G, STOCKHAMMER, G, RAVATHI DESAI, UEHARA, H, WATANABE, K, GANSBACHER, B, BLASBERG, R. G

“…Imaging the expression of successful gene transduction has been demonstrated in vivo for the first time by using an appropriate combination of "marker gene"…”
Get full text

Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo by TJUVAJEV, J. G, SHU HSIA CHEN, BLASBERG, R. G, JOSHI, A, JOSHI, R, ZONG SHENG GUO, BALATONI, J, BALLON, D, KOUTCHER, J, FINN, R, WOO, S. L

“…The feasibility of noninvasive imaging of adenoviral-mediated herpes virus type one thymidine kinase (HSV1-tk) gene transfer and expression was assessed in a…”
Get full text

Noninvasive Quantitation of Cytosine Deaminase Transgene Expression in Human Tumor Xenografts with in vivo Magnetic Resonance Spectroscopy by Stegman, Lauren D., Rehemtulla, Alnawaz, Beattie, Bradley, Kievit, Els, Lawrence, Theodore S., Blasberg, Ronald G., Tjuvajev, Juri G., Ross, Brian D.

“…Analysis of transgene expression in vivo currently requires destructive and invasive molecular assays of tissue specimens. Noninvasive methodology for…”
Get full text

Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression : Effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts by OKU, T, TJUVAJEV, J. G, MIYAGAWA, T, SASAJIMA, T, JOSHI, A, JOSHI, R, FINN, R, CLAFFEY, K. P, BLASBERG, R. G

“…Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, has been investigated as a potent mediator of brain tumor angiogenesis…”
Get full text

Development of a New Reporter Gene System-dsRed/Xanthine Phosphoribosyltransferase-Xanthine for Molecular Imaging of Processes Behind the Intact Blood-Brain Barrier by Doubrovin, Mikhail, Ponomarev, Vladimir, Serganova, Inna, Soghomonian, Suren, Myagawa, Tadashi, Beresten, Tatiana, Ageyeva, Lyudmila, Sadelain, Michel, Koutcher, Jason, Blasberg, Ronald G, Tjuvajev, Juri G. Gelovani

“…We report the development of a novel dual-modality fusion reporter gene system consisting of Escherichia coli xanthine phosphoribosyltransferase (XPRT) for…”
Get full text

A General Approach to the Non-Invasive Imaging of Transgenes Using Cis-Linked Herpes Simplex Virus Thymidine Kinase by Tjuvajev, Juri G., Joshi, Arjun, Callegari, James, Lindsley, Laura, Joshi, Revathi, Balaton, Julius, Find, Ronald, Larso, Steven M., Sadelain, Michel, Blasberg, Ronald G.

“…Non-invasive imaging of gene expression opens new prospects for the study of transgenic animals and the implementation of genetically based therapies in…”
Get full text

Development of a New Reporter Gene System—dsRed/Xanthine Phosphoribosyltransferase-Xanthine for Molecular Imaging of Processes Behind the Intact Blood-Brain Barrier by Doubrovin, Mikhail, Ponomarev, Vladimir, Serganova, Inna, Soghomonian, Suren, Myagawa, Tadashi, Beresten, Tatiana, Ageyeva, Lyudmila, Sadelain, Michel, Koutcher, Jason, Blasberg, Ronald G., Gelovani Tjuvajev, Juri G.

Get full text

Imaging of Brain Tumor Proliferative Activity with Iodine-131-Iododeoxyuridine by Tjuvajev, Juri G, Macapinlac, Homer A, Daghighian, Farhad, Scott, Andrew M, Ginos, James Z, Finn, Ronald D, Kothari, Paresh, Desai, Revathi, Zhang, Jiaju, Beattie, Bradley, Graham, Martin, Larson, Steven M, Blasberg, Ronald G

“…Iodine-131-iododeoxyuridine (IUdR) uptake and retention was imaged with SPECT at 2 and 24 hr after administering a 10-mCi dose to six patients with primary…”
Get full text

A General Approach to the Non-Invasive Imaging of Transgenes Using Cis-Linked Herpes Simplex Virus Thymidine Kinase1 by Tjuvajev, Juri G, Joshi, Arjun, Callegari, James, Lindsley, Laura, Joshi, Revathi, Balatoni, Julius, Finn, Ronald, Larson, Steven M, Sadelain, Michel, Blasberg, Ronald G

“…Non-invasive imaging of gene expression opens new prospects for the study of transgenic animals and the implementation of genetically based therapies in…”
Get full text

Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats by KAPLITT, M. G, TJUVAJEV, J. G, LEIB, D. A, BERK, J, PETTIGREW, K. D, POSNER, J. B, PFAFF, D. W, RABKIN, S. D, BLASBERG, R. G

“…Herpes simplex virus (HSV) mutants kill dividing tumor cells but spare non-proliferating, healthy brain tissue and may be useful in developing new treatment…”
Get full text

Abstracts by Derlon, J. M., Petit-taboué, M. C., Dauphin, F., Courtheoux, P., Chapon, F., Creissard, P., Darcel, F., Houtteville, J. P., Kaschten, B., Sadzot, B., Stevenaert, A., Tjuvajev, Juri G., Macapinlac, Homer A., Daghighian, Farhad, Ginos, James Z., Finn, Ronald D., Jiaju Zhang, M. S., Beattie, Bradley, Graham, Martin, Larson, Steven M., Blasberg, Ronald G., Levivier, M., Goldman, S., Pirotte, B., Brucher, J. M., Balériaux, D., Luxen, A., Hildebrand, J., Brotchi, J., Go, K. G., Kamman, R. L., Mooyaart, E. L., Heesters, M. A. A. M., Sijens, P. E., Oudksrk, M., van Dijk, P., Levendag, P. C., Vecht, Ch. J., Metz, R. J., Kennedy, D. N., Rosen, B. R., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Caviness, V. S., Gross, M. W., Weinzierl, F. X., Trappe, A. E., Goebel, W. E., Frank, A. M., Becker, Georg, Krone, Andreas, Schmidt, Karsten, Hofmann, Erich, Bogdahn, Ulrich, Bencsch, H., Fclber, S., Finkenstedt, G., Kremser, C., Sfockhammer, G., Aichner, F., Bogdahn, U., Fröhlich, T., Becker, G., Krone, A., Schlief, R., Schürmann, J., Jachimczak, P., Hofmann, E., Roggendorf, W., Roosen, K., Carapella, C. M., Carpinelli, G., Passalacqua, R., Raus, L., Giannini, M., Mastrostefano, R., Podo, F., Tofani, A., Maslrostefano, R., Mottoles, M., Ferraironi, A., Scelsa, M. G., Oppido, P., Riccio, A., Maini, C. L., Collombier, L., Taillandier, L., Dcbouverie, M., Laurens, M. H., Thouvenot, P., Weber, M., Bertrand, A., Cruickshank, G. S., Patterson, J., Hadley, D., De Witte, Olivier, Hildebrand, Jerzy, Luxen, André, Goldman, Serge

Get full text