Search Results - "TITZE, Jens"

Lymph vessels, Na+ and the teleological science of hypertension by Titze, Jens M.

“…A recent study reports that adenosine A2A receptor-mediated lymphangiogenesis increases lymphatic clearance of excess Na + from the skin and reduces blood…”
Get full text

Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation by Marton, Adriana, Kaneko, Tatsuroh, Kovalik, Jean-Paul, Yasui, Atsutaka, Nishiyama, Akira, Kitada, Kento, Titze, Jens

“…Therapeutic inhibition of the sodium–glucose co-transporter 2 (SGLT2) leads to substantial loss of energy (in the form of glucose) and additional solutes (in…”
Get full text

Speculations on salt and the genesis of arterial hypertension by Titze, Jens, Luft, Friedrich C

“…Blood pressure salt sensitivity and salt resistance are mechanistically imperfectly explained. A prescient systems medicine approach by Guyton and…”
Get more information

Magnetic resonance-determined sodium removal from tissue stores in hemodialysis patients by Dahlmann, Anke, Dörfelt, Kathrin, Eicher, Florian, Linz, Peter, Kopp, Christoph, Mössinger, Irina, Horn, Stephan, Büschges-Seraphin, Beatrix, Wabel, Peter, Hammon, Matthias, Cavallaro, Alexander, Eckardt, Kai-Uwe, Kotanko, Peter, Levin, Nathan W, Johannes, Bernd, Uder, Michael, Luft, Friedrich C, Müller, Dominik N, Titze, Jens M

“…We have previously reported that sodium is stored in skin and muscle. The amounts stored in hemodialysis (HD) patients are unknown. We determined whether…”
Get more information

Salt-responsive gut commensal modulates TH17 axis and disease by Wilck, Nicola, Matus, Mariana G., Kearney, Sean M., Olesen, Scott W., Forslund, Kristoffer, Bartolomaeus, Hendrik, Haase, Stefanie, Mähler, Anja, Balogh, András, Markó, Lajos, Vvedenskaya, Olga, Kleiner, Friedrich H., Tsvetkov, Dmitry, Klug, Lars, Costea, Paul I., Sunagawa, Shinichi, Maier, Lisa, Rakova, Natalia, Schatz, Valentin, Neubert, Patrick, Frätzer, Christian, Krannich, Alexander, Gollasch, Maik, Grohme, Diana A., Côrte-Real, Beatriz F., Gerlach, Roman G., Basic, Marijana, Typas, Athanasios, Wu, Chuan, Titze, Jens M., Jantsch, Jonathan, Boschmann, Michael, Dechend, Ralf, Kleinewietfeld, Markus, Kempa, Stefan, Bork, Peer, Linker, Ralf A., Alm, Eric J., Müller, Dominik N.

“…A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T…”
Get full text

Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension by Barbaro, Natalia R., Foss, Jason D., Kryshtal, Dmytro O., Tsyba, Nikita, Kumaresan, Shivani, Xiao, Liang, Mernaugh, Raymond L., Itani, Hana A., Loperena, Roxana, Chen, Wei, Dikalov, Sergey, Titze, Jens M., Knollmann, Bjorn C., Harrison, David G., Kirabo, Annet

“…Sodium accumulates in the interstitium and promotes inflammation through poorly defined mechanisms. We describe a pathway by which sodium enters dendritic…”
Get full text

High-Salt Diet Causes Osmotic Gradients and Hyperosmolality in Skin Without Affecting Interstitial Fluid and Lymph by Nikpey, Elham, Karlsen, Tine V, Rakova, Natalia, Titze, Jens M, Tenstad, Olav, Wiig, Helge

“…The common notion is that the body Na is maintained within narrow limits for fluid and blood pressure homeostasis. Several studies have, however, shown that…”
Get full text

Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD by Schneider, Markus P, Raff, Ulrike, Kopp, Christoph, Scheppach, Johannes B, Toncar, Sebastian, Wanner, Christoph, Schlieper, Georg, Saritas, Turgay, Floege, Jürgen, Schmid, Matthias, Birukov, Anna, Dahlmann, Anke, Linz, Peter, Janka, Rolf, Uder, Michael, Schmieder, Roland E, Titze, Jens M, Eckardt, Kai-Uwe

“…The pathogenesis of left ventricular hypertrophy in patients with CKD is incompletely understood. Sodium intake, which is usually assessed by measuring urinary…”
Get full text

Hemodynamics and Salt-and-Water Balance Link Sodium Storage and Vascular Dysfunction in Salt-Sensitive Subjects by Laffer, Cheryl L, Scott, Robert C, Titze, Jens M, Luft, Friedrich C, Elijovich, Fernando

“…We investigated 24-hour hemodynamic changes produced by salt loading and depletion in 8 salt-sensitive (SS) and 13 salt-resistant (SR) normotensive volunteers…”
Get full text

Iatrogenic dehydration drives organic osmolyte production in critical COVID‐19 by Hultström, Michael, Nihlén, Sandra, Titze, Jens M., Lipcsey, Miklos, Frithiof, Robert

“…Fluid removal with concomitant dehydration is a common treatment strategy in acute respiratory distress syndrome (ARDS). We have previously shown that…”
Get full text

Renal sympathetic nerve activity regulates cardiovascular energy expenditure in rats fed high salt by Morisawa, Norihiko, Kitada, Kento, Fujisawa, Yoshihide, Nakano, Daisuke, Yamazaki, Daisuke, Kobuchi, Shuhei, Li, Lei, Zhang, Yifan, Morikawa, Takashi, Konishi, Yoshio, Yokoo, Takashi, Luft, Friedrich C, Titze, Jens, Nishiyama, Akira

“…We recently reported that a 4% high-salt diet + saline for drinking (HS + saline) leads to a catabolic state, reduced heart rate, and suppression of…”
Get full text

High salt reduces the activation of IL-4- and IL-13-stimulated macrophages by Binger, Katrina J, Gebhardt, Matthias, Heinig, Matthias, Rintisch, Carola, Schroeder, Agnes, Neuhofer, Wolfgang, Hilgers, Karl, Manzel, Arndt, Schwartz, Christian, Kleinewietfeld, Markus, Voelkl, Jakob, Schatz, Valentin, Linker, Ralf A, Lang, Florian, Voehringer, David, Wright, Mark D, Hubner, Norbert, Dechend, Ralf, Jantsch, Jonathan, Titze, Jens, Müller, Dominik N

“…A high intake of dietary salt (NaCl) has been implicated in the development of hypertension, chronic inflammation, and autoimmune diseases. We have recently…”
Get full text

High-Salt Diet Causes Expansion of the Lymphatic Network and Increased Lymph Flow in Skin and Muscle of Rats by Karlsen, Tine V, Nikpey, Elham, Han, Jianhua, Reikvam, Tore, Rakova, Natalia, Castorena-Gonzalez, Jorge A, Davis, Michael J, Titze, Jens M, Tenstad, Olav, Wiig, Helge

“…OBJECTIVE—A commonly accepted pivotal mechanism in fluid volume and blood pressure regulation is the parallel relationship between body Na and extracellular…”
Get full text

Sodium Handling and Interaction in Numerous Organs by Minegishi, Shintaro, Luft, Friedrich C, Titze, Jens, Kitada, Kento

“…Abstract Salt (NaCl) is a prerequisite for life. Excessive intake of salt, however, is said to increase disease risk, including hypertension, arteriosclerosis,…”
Get full text

Increased salt consumption induces body water conservation and decreases fluid intake by Rakova, Natalia, Kitada, Kento, Lerchl, Kathrin, Dahlmann, Anke, Birukov, Anna, Daub, Steffen, Kopp, Christoph, Pedchenko, Tetyana, Zhang, Yahua, Beck, Luis, Johannes, Bernd, Marton, Adriana, Müller, Dominik N, Rauh, Manfred, Luft, Friedrich C, Titze, Jens

“…The idea that increasing salt intake increases drinking and urine volume is widely accepted. We tested the hypothesis that an increase in salt intake of 6 g/d…”
Get full text

Contributions of renal water loss and skin water conservation to blood pressure elevation in spontaneously hypertensive rats by Ogura, Takahiro, Kitada, Kento, Morisawa, Norihiko, Fujisawa, Yoshihide, Kidoguchi, Satoshi, Nakano, Daisuke, Kobara, Hideki, Masaki, Tsutomu, Titze, Jens, Nishiyama, Akira

“…We recently reported that skin vasoconstriction to suppress transepidermal water loss (TEWL) leads to hypertension in renal injury model rats with impaired…”
Get full text

Agreement Between 24-Hour Salt Ingestion and Sodium Excretion in a Controlled Environment by Lerchl, Kathrin, Rakova, Natalia, Dahlmann, Anke, Rauh, Manfred, Goller, Ulrike, Basner, Mathias, Dinges, David F, Beck, Luis, Agureev, Alexander, Larina, Irina, Baranov, Victor, Morukov, Boris, Eckardt, Kai-Uwe, Vassilieva, Galina, Wabel, Peter, Vienken, Jörg, Kirsch, Karl, Johannes, Bernd, Krannich, Alexander, Luft, Friedrich C, Titze, Jens

“…Accurately collected 24-hour urine collections are presumed to be valid for estimating salt intake in individuals. We performed 2 independent ultralong-term…”
Get full text

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation by Kitada, Kento, Daub, Steffen, Zhang, Yahua, Klein, Janet D, Nakano, Daisuke, Pedchenko, Tetyana, Lantier, Louise, LaRocque, Lauren M, Marton, Adriana, Neubert, Patrick, Schröder, Agnes, Rakova, Natalia, Jantsch, Jonathan, Dikalova, Anna E, Dikalov, Sergey I, Harrison, David G, Müller, Dominik N, Nishiyama, Akira, Rauh, Manfred, Harris, Raymond C, Luft, Friedrich C, Wassermann, David H, Sands, Jeff M, Titze, Jens

“…Natriuretic regulation of extracellular fluid volume homeostasis includes suppression of the renin-angiotensin-aldosterone system, pressure natriuresis, and…”
Get full text

Vascular inflammatory cells in hypertension by Harrison, David G, Marvar, Paul J, Titze, Jens M

“…Hypertension is a common disorder with uncertain etiology. In the last several years, it has become evident that components of both the innate and adaptive…”
Get full text

Abnormal sodium and water homeostasis in mice with defective heparan sulfate polymerization by Olde Engberink, Rik H G, de Vos, Judith, van Weert, Angela, Zhang, Yahua, van Vlies, Naomi, van den Born, Bert-Jan H, Titze, Jens M, van Bavel, Ed, Vogt, Liffert

“…Glycosaminoglycans in the skin interstitium and endothelial surface layer have been shown to be involved in local sodium accumulation without commensurate…”
Get full text