Search Results - "TITSCH, Craig"

Fully Validated LC-MS/MS Assay for the Simultaneous Quantitation of Coadministered Therapeutic Antibodies in Cynomolgus Monkey Serum by Jiang, Hao, Zeng, Jianing, Titsch, Craig, Voronin, Kimberly, Akinsanya, Billy, Luo, Linlin, Shen, Hongwu, Desai, Dharmesh D., Allentoff, Alban, Aubry, Anne-Françoise, DeSilva, Binodh S., Arnold, Mark E.

“…An LC-MS/MS assay was developed and fully validated for the simultaneous quantitation of two coadministered human monoclonal antibodies (mAbs), mAb-A and mAb-B…”
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Innovative Use of LC-MS/MS for Simultaneous Quantitation of Neutralizing Antibody, Residual Drug, and Human Immunoglobulin G in Immunogenicity Assay Development by Jiang, Hao, Xu, Weifeng, Titsch, Craig A., Furlong, Michael T., Dodge, Robert, Voronin, Kimberly, Allentoff, Alban, Zeng, Jianing, Aubry, Anne-Françoise, DeSilva, Binodh S., Arnold, Mark E.

“…Immunogenicity testing for antidrug antibodies (ADA) faces challenges when high levels of the drug are present in clinical patient samples. In addition, most…”
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High-Throughput Therapeutic Antibody Interference-Free High-Resolution Mass Spectrometry Assay for Monitoring M‑Proteins in Multiple Myeloma by Santockyte, Rasa, Puig, Oscar, Zheng, Naiyu, Ouyang, Zheng, Titsch, Craig, Zhang, Yang J, Pillutla, Renuka, Zeng, Jianing

“…Measurement of monoclonal antibodies (M-proteins) plays an important role in the diagnosis and treatment monitoring of multiple myeloma. Currently available…”
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Singlicate Ligand Binding Assay Using an Automated Microfluidic System: a Clinical Case Study by Jiang, Hao, Kozhich, Alex, Cummings, Jennifer, Gambardella, Janice, Zambito, Frank, Titsch, Craig, Haulenbeek, Jonathan, Phillips, Kelli, Fergus, Ross, Myler, Heather

“…The bioanalytical strategy for monoclonal antibody therapeutics, intended for multiple oncology indications, includes multiple integrated measurements of…”
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Overcoming interference with the detection of a stable isotopically labeled microtracer in the evaluation of beclabuvir absolute bioavailability using a concomitant microtracer approach by Jiang, Hao, Titsch, Craig, Zeng, Jianing, Jones, Barry, Joyce, Philip, Gandhi, Yash, Turley, Wesley, Burrell, Richard, Aubry, Anne F., Arnold, Mark E.

“…•Interference with detection of the microtracer was greater than theoretical prediction.•Two different approaches were applied to overcome the…”
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Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation by Shen, Hong, Liu, Tongtong, Jiang, Hao, Titsch, Craig, Taylor, Kristin, Kandoussi, Hamza, Qiu, Xi, Chen, Cliff, Sukrutharaj, Sunil, Kuit, Kathy, Mintier, Gabe, Krishnamurthy, Prasad, Fancher, R Marcus, Zeng, Jianing, Rodrigues, A David, Marathe, Punit, Lai, Yurong

“…Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2K mediate the renal secretion of various cationic drugs and can…”
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An exploratory universal LC-MS/MS assay for bioanalysis of hinge region-stabilized human IgG4 mAbs in clinical studies by Furlong, Michael T, Titsch, Craig, Xu, Weifeng, Jiang, Hao, Jemal, Mohammed, Zeng, Jianing

“…Due to the increasing number of monoclonal antibody (mAb) drug candidates entering clinical development, bioanalytical laboratories can benefit from generic…”
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Practical and Efficient Strategy for Evaluating Oral Absolute Bioavailability with an Intravenous Microdose of a Stable Isotopically-Labeled Drug Using a Selected Reaction Monitoring Mass Spectrometry Assay by Jiang, Hao, Zeng, Jianing, Li, Wenying, Bifano, Marc, Gu, Huidong, Titsch, Craig, Easter, John, Burrell, Richard, Kandoussi, Hamza, Aubry, Anne-Françoise, Arnold, Mark E

“…A strategy of using selected reaction monitoring (SRM) mass spectrometry for evaluating oral absolute bioavailability with concurrent intravenous (IV)…”
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Development and characterization of a pre-treatment procedure to eliminate human monoclonal antibody therapeutic drug and matrix interference in cell-based functional neutralizing antibody assays by Xu, Weifeng, Jiang, Hao, Titsch, Craig, Haulenbeek, Jonathan R., Pillutla, Renuka C., Aubry, Anne-Françoise, DeSilva, Binodh S., Arnold, Mark E., Zeng, Jianing, Dodge, Robert W.

“…Biological therapeutics can induce an undesirable immune response resulting in the formation of anti-drug antibodies (ADA), including neutralizing antibodies…”
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SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models by GALAS, Jennifer M, LUCAS, Judy, FANGBIAO LI, TITSCH, Craig, HUSELTON, Christine, CHAUDHARY, Inder, BOSCHELLI, Frank, ETIENNE, Carlo, GOLAS, Jonathan, DISCAFANI, Carolyn, SRIDHARAN, Latha, BOGHAERT, Erwin, ARNDT, Kim, FEI YE, BOSCHELLI, Diane H

“…Src up-regulation is a common event in human cancers. In colorectal cancer, increased Src levels are an indicator of poor prognosis, and progression to…”
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Concerted application of LC-MS and ligand binding assays to better understand exposure of a large molecule drug by Xu, Weifeng, Jiang, Hao, Titsch, Craig, Gadkari, Snaehal, Batog, Alicja, Wang, Bonnie, Hippeli, Lauren, Yamamoto, Brent, Chadwick, Kristina, Wheeler, Jennifer, Thompson, Chris, Stahl, James, Willett, Scott, DeSilva, Binodh S, Myler, Heather, Dodge, Robert W, Pillutla, Renuka C

“…A ligand-binding assay (LBA) was used to measure exposure of PRM-151, the recombinant form of human pentraxin-2 (PTX-2), a complex pentamer with multiple…”
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