Search Results - "TITIER, Karine"

High throughput routine determination of 17 tyrosine kinase inhibitors by LC–MS/MS by Merienne, Camille, Rousset, Marine, Ducint, Dominique, Castaing, Nadège, Titier, Karine, Molimard, Mathieu, Bouchet, Stéphane

“…•The aim of this assay is to develop a tool to quantify tyrosine kinase inhibitors.•The tool must be fast with high throughput.•Solid phase extraction,…”
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Simultaneous determination of nine tyrosine kinase inhibitors by 96-well solid-phase extraction and ultra performance LC/MS-MS by Bouchet, Stéphane, Chauzit, Emmanuelle, Ducint, Dominique, Castaing, Nadège, Canal-Raffin, Mireille, Moore, Nicholas, Titier, Karine, Molimard, Mathieu

“…Tyrosine Kinase Inhibitors (TKIs) are a class of targeted drugs for the treatment of malignant pathologies. The metabolic profile of these drugs can result in…”
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Trough dabrafenib plasma concentrations can predict occurrence of adverse events requiring dose reduction in metastatic melanoma by Rousset, Marine, Dutriaux, Caroline, Bosco-Lévy, Pauline, Prey, Sorilla, Pham-Ledard, Anne, Dousset, Léa, Gérard, Emilie, Bouchet, Stephane, Canal-Raffin, Mireille, Titier, Karine, Molimard, Mathieu

“…Dabrafenib and trametinib bitherapy provides significant benefits in BRAFV600mut metastatic melanoma patients; however, adverse events (AE) occur, leading to…”
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Highly sensitive LC–MS/MS methods for urinary biological monitoring of occupational exposure to cyclophosphamide, ifosfamide, and methotrexate antineoplastic drugs and routine application by Canal-Raffin, Mireille, Khennoufa, Karim, Martinez, Béatrice, Goujon, Yves, Folch, Celia, Ducint, Dominique, Titier, Karine, Brochard, Patrick, Verdun-Esquer, Catherine, Molimard, Mathieu

“…•Two highly sensitive methods in urine are proposed for healthcare professionals biomonitoring occupationaly exposed to antineoplastic drugs.•For…”
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Therapeutic drug monitoring of imatinib in chronic myeloid leukemia: experience from 1216 patients at a centralized laboratory by Bouchet, Stéphane, Titier, Karine, Moore, Nicholas, Lassalle, Régis, Ambrosino, Basmah, Poulette, Sylvie, Schuld, Peter, Belanger, Coralie, Mahon, François-Xavier, Molimard, Mathieu

“…This study set out to examine in a large real‐life cohort of patients with chronic myeloid leukemia (CML) the impact of imatinib threshold of 1000 ng/mL on…”
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Quantification of imatinib in human plasma by high-performance liquid chromatography-tandem mass spectrometry by Titier, Karine, Picard, Stéphane, Ducint, Dominique, Teilhet, Emmanuelle, Moore, Nicholas, Berthaud, Patrice, Mahon, François-Xavier, Molimard, Mathieu

“…Imatinib, also known as Gleevec or Glivec, is a selective tyrosine kinase inhibitor currently used for the treatment of Philadelphia chromosome-positive…”
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Quantification methods of folpet degradation products in plasma with HPLC-UV/DAD: Application to an in vivo toxicokinetic study in rats by Canal-Raffin, Mireille, Receveur, Mathilde, Martinez, Béatrice, Titier, Karine, Ohayon, Celine, Baldi, Isabelle, Molimard, Mathieu, Moore, Nicholas, Brochard, Patrick

“…Solid-phase extractions followed by HPLC-UV/DAD methods were developed for occupational biological monitoring or forensic investigations of the fungicide…”
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Simplified ultraviolet liquid chromatographic method for determination of sertindole, dehydrosertindole and norsertindole, in human plasma by Canal-Raffin, Mireille, Déridet, Evelyne, Titier, Karine, Frakra, Eric, Molimard, Mathieu, Moore, Nicholas

“…An ultra-violet high-performance liquid chromatographic method was developed for the determination of sertindole, an atypical antipsychotic drug and its main…”
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Establishment of the medico-legal cause of death in two atypical cases of gas embolism in hospital: Importance of the scene by Benali, Larbi, MD, Abriat, Frédéric, MD, Titier, Karine, PharmD, PhD, Robinson, Philip, Medical Writer, PhD, Gromb, Sophie, MD, PhD

“…Abstract Two cases of lethal gas embolism occurring in a hospital setting are presented. These did not differ with regards to the medical cause of death…”
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High-performance liquid chromatographic method for the simultaneous determination of the six HIV-protease inhibitors and two non-nucleoside reverse transcriptase inhibitors in human plasma by TITIER, Karine, LAGRANGE, Fabrice, PEHOURCQ, Fabienne, EDNO-MCHEIK, Leila, MOORE, Nicholas, MOLIMARD, Mathieu

“…A selective and sensitive high-performance liquid chromatographic (HPLC) method has been developed for the determination of the six human immunodeficiency…”
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In Vivo and in Vitro Myocardial Binding of Risperidone and 9-Hydroxyrisperidone by Titier, Karine, Déridet, Evelyne, Moore, Nicholas

“…Antipsychotic drugs have been found to prolong the QT interval, a phenomenon that, when severe, may facilitate the occurrence of complex ventricular arrhythmia…”
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Hair Analysis of Methoxphenidine in a Forensic Chemsex Case: J Anal Toxicol by Goncalves, Ruben, Castaing, Nadege, Titier, Karine, Dumestre-Toulet, Veronique

“…Methoxphenidine (MXP, 2-MeO-diphenidine) is a dissociative anaesthetic drug of the diarylethylamine type, recently introduced for recreational purposes through…”
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Hair Analysis of Methoxphenidine in a Forensic Chemsex Case by Goncalves, Ruben, Castaing, Nadege, Titier, Karine, Dumestre-Toulet, Véronique

“…Methoxphenidine (MXP, 2-MeO-diphenidine) is a dissociative anesthetic drug of the diarylethylamine type, recently introduced for recreational purposes through…”
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An UPLC-MS/MS method for the quantification of BRAF inhibitors (vemurafenib, dabrafenib) and MEK inhibitors (cobimetinib, trametinib, binimetinib) in human plasma. Application to treated melanoma patients by Rousset, Marine, Titier, Karine, Bouchet, Stephane, Dutriaux, Caroline, Pham-Ledard, Anne, Prey, Sorilla, Canal-Raffin, Mireille, Molimard, Mathieu

“…Targeted therapies for cancers are fast-growing therapies. For instance kinase inhibitors such as BRAF inhibitors (BRAFi) and MEK inhibitors (MEKi) are…”
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Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia by Picard, Stephane, Titier, Karine, Etienne, Gabriel, Teilhet, Emmanuelle, Ducint, Dominique, Bernard, Marie-Agnes, Lassalle, Regis, Marit, Gerald, Reiffers, Josy, Begaud, Bernard, Moore, Nicholas, Molimard, Mathieu, Mahon, Francois-Xavier

“…Using high-performance liquid chromatography–tandem mass spectrometry, we assessed trough imatinib plasma levels in 68 patients with chronic myeloid leukemia…”
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Relationship between imatinib trough concentration and outcomes in the treatment of advanced gastrointestinal stromal tumours in a real-life setting by Bouchet, Stéphane, Poulette, Sylvie, Titier, Karine, Moore, Nicholas, Lassalle, Régis, Abouelfath, Abdelilah, Italiano, Antoine, Chevreau, Christine, Bompas, Emmanuelle, Collard, Olivier, Duffaud, Florence, Rios, Maria, Cupissol, Didier, Adenis, Antoine, Ray-Coquard, Isabelle, Bouché, Olivier, Le Cesne, Axel, Bui, Binh, Blay, Jean-Yves, Molimard, Mathieu

“…Abstract Background Imatinib has dramatically improved the prognosis of advanced gastrointestinal stromal tumours (GISTs). Clinical trial data showed that…”
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Letter to the Editor: The Cannabinoid Consumed Is Not Necessarily the One Expected: Recent Experience with Hexahydrocannabinol by Guyon, Joris, Paradis, Camille, Titier, Karine, Braganca, Coralie, Peyre, Alexandre, Nardon, Audrey, Daveluy, Amélie, Molimard, Mathieu, Labadie, Magali, Castaing, Nadège

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Methoxpropamine (MXPr) in powder, urine and hair samples: Analytical characterization and metabolite identification of a new threat by Goncalves, R., Castaing, N., Richeval, C., Ducint, D., Titier, K., Morvan, E., Grélard, A., Loquet, A., Molimard, M.

“…•First identification of MXPr in France with analytical findings.•Identification of new psychoactive substances requires combined methods such as RMN, IR and…”
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High throughput routine determination of 17 tyrosine kinase inhibitors by LC-MS/MS: J Pharm Biomed Anal by Merienne, Camille, Rousset, Marine, Ducint, D., Castaing, N., Titier, Karine, Molimard, Mathieu, Bouchet, Stéphane

“…Several studies have shown that therapeutic drug monitoring of tyrosine kinase inhibitors (TKI) can improve their benefit in cancer. An analytical tool has…”
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Toxicological screening reveals toxic epidermal necrolysis likely carbamazepine-induced rather than idiopathic by Toussaint, Clementine, Sanchez-Pena, Paola, Titier, Karine, Castaing, Nadege, Molimard, Mathieu, Milpied, Brigitte

“…[...]toxicological screening through liquid chromatography tandem mass spectrometry ruled out the “idiopathic” nature of the case. To complete our…”
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