Search Results - "TITHERADGE, M. A"

Simultaneous quantitation of homocysteine, cysteine and methionine in plasma and urine by liquid chromatography-tandem mass spectrometry by Weaving, G, Rocks, B F, Iversen, S A, Titheradge, M A

“…A method utilizing liquid chromatography-electrospray tandem mass spectrometry (LC-MS/MS) has been developed and evaluated for the determination of total…”
Get more information

Nitric oxide in septic shock by Titheradge, Michael A

“…Septic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world. It is characterised by…”
Get full text

Inhibition of hepatic gluconeogenesis by nitric oxide : a comparison with endotoxic shock by HORTON, R. A, CEPPI, E. D, KNOWLES, R. G, TITHERADGE, M. A

“…Isolated hepatocytes incubated in the presence of the NO donors S-nitroso-N-acetylpenicillamine (SNAP) and 3-morpholino-sydnonimine (SIN-1) displayed a time-…”
Get full text

The enzymatic measurement of nitrate and nitrite by Titheradge, M A

Get more information

The role of transforming growth factor-β1 and oxidative stress in podoconiosis pathogenesis by Addisu, S., El-Metwally, T.H., Davey, G., Worku, Y., Titheradge, M.A.

“…Summary Background  Podoconiosis (endemic nonfilarial elephantiasis) occurs in susceptible individuals who go barefoot in regions of irritant volcanic soil…”
Get full text

Effect of dexamethasone on gluconeogenesis, pyruvate kinase, pyruvate carboxylase and pyruvate dehydrogenase flux in isolated hepatocytes by JONES, C. G, HOTHI, S. K, TITHERADGE, M. A

“…Treatment of 18 h-starved rats with dexamethasone and subsequent isolation and incubation of the hepatocytes in the presence of the steroid increased…”
Get full text

The effect of treatment of the rat with bacterial endotoxin on gluconeogenesis and pyruvate metabolism in subsequently isolated hepatocytes by Jones, C G, Titheradge, M A

“…The effect of treatment of rats with bacterial endotoxin on gluconeogenesis and the flux through pyruvate kinase, phosphoenolpyruvate carboxykinase (PEPCK),…”
Get full text

Physiological concentrations of 2-oxoglutarate regulate the activity of phosphoenolpyruvate carboxykinase in liver by TITHERADGE, M. A, PICKING, R. A, HAYNES, R. C

“…2-Oxoglutarate was found to inhibit purified rat liver phosphoenolpyruvate carboxykinase when the assay was performed in the direction of either…”
Get full text

Effect of treatment in vivo of rats with bacterial endotoxin on fructose 2,6-bisphosphate metabolism and L-pyruvate kinase activity and flux in isolated liver cells by CEPPI, E. D, KNOWLES, R. G, CARPENTER, K. M, TITHERADGE, M. A

“…The effect of treatment of rats with bacterial endotoxin on fructose 2,6-bisphosphate (Fru-2,6-P2) metabolism was investigated in isolated liver cells prepared…”
Get full text

Nitric oxide, sepsis and liver metabolism by Ceppi, E D, Smith, F S, Titheradge, M A

Get more information

The occurrence and receptor specificity of endogenous opioid peptides within the pancreas and liver of the rat. Comparison with brain by Khawaja, X Z, Green, I C, Thorpe, J R, Titheradge, M A

“…Our observations that opioid peptides have direct effects on islet insulin secretion and liver glucose production prompted a search for endogenous opiates and…”
Get full text

GLUCAGON DECREASES CYTOKINE INDUCTION OF NITRIC OXIDE SYNTHASE AND ACTION ON INSULIN SECRETION IN RIN5F CELLS AND RAT AND HUMAN ISLETS OF LANGERHANS by Belin, V.D, Mabley, J.G, James, R.F.L, Swift, S.M, Clayton, H.A, Titheradge, M.A, Green, I.C

“…Nitric oxide synthase, induced by cytokines in insulin-containing cells, produces nitric oxide which inhibits function and may promote cell killing. Since…”
Get full text

Mechanism of inhibition of hepatic gluconeogenesis by bacterial endotoxin: a role for nitric oxide? by Titheradge, M A, Knowles, R G, Smith, F S, Horton, R A, Ceppi, E D

Get more information

Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis and gluconeogenesis by Horton, R A, Knowles, R G, Titheradge, M A

Get more information

The control of uncoupler-activated ATPase activity in rat liver mitochondria by adenine nucleotide transport. The effect of glucagon treatment by M A Titheradge, R C Haynes, Jr

“…Acute treatment of rats with glucagon increased the Vmax but did not change the Km (ATP) of uncoupler-activated ATPase in subsequently isolated hepatic…”
Get full text

The stimulation of glycogenolysis in isolated hepatocytes by opioid peptides by Leach, R P, Titheradge, M A

“…The opioid peptides [Leu]enkephalin and dynorphin-(1-13) were shown to enhance glycogen breakdown when added directly to hepatocytes. This was the result of a…”
Get full text

Detection of NOS isoforms by western-blot analysis by Smith, F S, Titheradge, M A

Get more information

Stimulation of mitochondrial pyruvate metabolism and citrulline synthesis by dexamethasone. Effect of isolation and incubation media by Martin, A D, Titheradge, M A

“…Hepatic mitochondria isolated in 0.3 M-sucrose or 0.3 M-mannitol from rats treated for 3h with dexamethasone displayed stimulated rates of pyruvate…”
Get full text

Effect of endotoxin on fructose 2,6-bisphosphate in isolated hepatocytes by Ceppi, E D, Knowles, R G, Titheradge, M A

Get more information

Changes in free cytosolic calcium and accumulation of inositol phosphates in isolated hepatocytes by [Leu]enkephalin by Leach, R P, Shears, S B, Kirk, C J, Titheradge, M A

“…Isolated hepatocytes from fed rats were used to study the effects of the opioid peptide [Leu]enkephalin on intracellular free cytosolic Ca2+ ([Ca2+]i) and…”
Get full text