Search Results - "TIPPIN, T. K"

Synthetic LXR Ligand Inhibits the Development of Atherosclerosis in Mice by Joseph, Sean B., McKilligin, Elaine, Pei, Liming, Watson, Michael A., Collins, Alan R., Laffitte, Bryan A., Chen, Mingyi, Noh, Grace, Goodman, Joanne, Hagger, Graham N., Tran, Jonathan, Tippin, Tim K., Wang, Xuping, Lusis, Aldons J., Hsueh, Willa A., Law, Ronald E., Collins, Jon L., Willson, Timothy M., Tontonoz, Peter

“…The nuclear receptors LXRα and LXRβ have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these…”
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Orally active nonpeptide CCK-A agonists by Sugg, E E, Birkemo, L, Gan, L S, Tippin, T K

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6-Azasteroids : potent dual inhibitors of human type 1 and 2 steroid 5α-reductase by FRYE, S. V, HAFFNER, C. D, VAN ARNOLD, J, BICKETT, D. M, MOSS, M. L, GAOCHOA TIAN, UNWALLA, R. J, LEE, F. W, TIPPIN, T. K, JMAES, M. K, GRIZZLE, M. K, JAMES, M. K, MALONEY, P. R, SCHUSTER, S. V, MOOK, R. A, DORSEY, G. F, HINER, R. N, BATCHELOR, K. W, BRAMSON, H. N, STUART, J. D, SCHWEIKER, S. L

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Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines by Collins, Jon L, Fivush, Adam M, Watson, Michael A, Galardi, Cristin M, Lewis, Michael C, Moore, Linda B, Parks, Derek J, Wilson, Joan G, Tippin, Tim K, Binz, Jane G, Plunket, Kelli D, Morgan, Daniel G, Beaudet, Elizabeth J, Whitney, Karl D, Kliewer, Steven A, Willson, Timothy M

“…A potent, selective, orally active LXR agonist was identified from focused libraries of tertiary amines. GW3965 (12) recruits the steroid receptor coactivator…”
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Enhancing paracellular permeability by modulating epithelial tight junctions by Ward, Peter D, Tippin, Tim K, Thakker, Dhiren R

“…The intestinal epithelium is a major barrier to the absorption of hydrophilic drugs. The presence of intercellular junctional complexes, particularly the tight…”
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Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system by Whitney, Karl D, Watson, Michael A, Collins, Jon L, Benson, William G, Stone, Tammy M, Numerick, Mary Jo, Tippin, Timothy K, Wilson, Joan G, Winegar, Deborah A, Kliewer, Steven A

“…The nuclear oxysterol receptors liver X receptor-alpha [LXRalpha (NR1H3)] and LXRbeta (NR1H2) coordinately regulate genes involved in cholesterol homeostasis…”
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P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine by Polli, Joseph W, Baughman, Todd M, Humphreys, Joan E, Jordan, Kelly H, Mote, Angela L, Salisbury, Jo A, Tippin, Timothy K, Serabjit-Singh, Cosette J

“…Recent in vitro studies have suggested that P-glycoprotein (Pgp) and passive membrane permeability may influence the brain concentrations of non-sedating…”
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Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5alpha-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat by Stuart, J D, Lee, F W, Simpson Noel, D, Kadwell, S H, Overton, L K, Hoffman, C R, Kost, T A, Tippin, T K, Yeager, R L, Batchelor, K W, Bramson, H N

“…The interaction of baculovirus expressed rat steroid 5alpha-reductase types 1 and 2 (r5AR1 and r5AR2) with…”
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In vitro absorption and secretory quotients: practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates by Thiel-Demby, Victoria E, Tippin, Timothy K, Humphreys, Joan E, Serabjit-Singh, Cosette J, Polli, Joseph W

“…The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and…”
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Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases : determinants for different in vivo activities of GI198745 and finasteride in the rat by STUART, J. Darren, LEE, Frank W, BRAMSON, H. Neal, NOEL, Deborah Simpson, KADWELL, Sue H, OVERTON, Laurie K, HOFFMAN, Christine R, KOST, Thomas A, TIPPIN, Timothy K, YEAGER, Russell L, BATCHELOR, Kenneth W

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CYP3A induction by n-hydroxyformamide tumor necrosis factor-α converting enzyme/matrix metalloproteinase inhibitors: Use of a pregnane X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans by TIPPIN, Timothy K, HAMILTON, Geraldine, HOIVIK, Debie J, MELLON-KUSIBAB, Kathy, LEHMANN, Jurgen, KLIEWER, Steven, NOVICK, Steven, LAETHEM, Ron, ZHIYANG ZHAO, LECLUYSE, Edward L, MOORE, Linda, BEAUDET, Elizabeth J, JOLLEY, Summer, BRODIE, Thomas A, ANDREWS, Robert C, BECHERER, J. David, MCDOUGALD, Darryl L, GAUL, Michael D

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Structure-activity relationships for inhibition of type 1 and 2 human 5α-reductase and human adrenal 3β-hydroxy-Δ5-steroid dehydrogenase/3-keto-Δ5-steroid isomerase by 6-azaandrost-4-en-3-ones : optimization of the C17 substituent by FRYE, S. V, HAFFNER, C. D, SCHWEIKER, S. L, VAN ARNOLD, J, BICKETT, D. M, MOSS, M. L, GAOCHOA TIAN, LEE, F. W, TIPPIN, T. K, JAMES, M. K, GRIZZLE, M. K, LONG, J. E, MALONEY, P. R, CROOM, D. K, HINER, R. N, DORSEY, G. F, NOE, R. A, UNWALLA, R. J, BATCHELOR, K. W, BRAMSON, H. N, STUART, J. D

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N-Hydroxyformamide peptidomimetics as TACE/Matrix metalloprotease inhibitors: oral activity via P1′ isobutyl substitution by Musso, David L., Andersen, Marc W., Andrews, Robert C., Austin, Richard, Beaudet, Elizabeth J., Becherer, J.David, Bubacz, Dulce G., Bickett, D.Mark, Chan, Joseph H., Conway, James G., Cowan, David J., Gaul, Michael D., Glennon, Kimberly C., Hedeen, Kevin M., Lambert, Millard H., Leesnitzer, M.Anthony, McDougald, Darryl L., Mitchell, Justin L., Moss, Marcia L., Rabinowitz, Michael H., Rizzolio, Michele C., Schaller, Lee T., Stanford, Jennifer B., Tippin, Timothy K., Warner, Janet R., Whitesell, L.Graham, Wiethe, Robert W.

“…N-Hydroxyformamide-class metalloprotease inhibitors were designed and synthesized, which have potent broad-spectrum activity versus matrix metalloproteases and…”
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6-Azasteroids : structure-activity relationships for inhibition of type 1 and 2 human 5α-reductase and human adrenal 3β-hydroxy-Δ5-steroid dehydrogenase/3-keto-Δ5-steroid isomerase by FRYE, S. V, HAFFNER, C. D, BATCHELOR, K. W, BRAMSON, H. N, STUART, J. D, SCHWEIKER, S. L, VAN ARNOLD, J, CROOM, S, BICKETT, D. M, MOSS, M. L, TIAN, G, UNWALLA, R. J, MALONEY, P. R, LEE, F. W, TIPPIN, T. K, JAMES, M. K, GRIZZLE, M. K, LONG, J. E, SCHUSTER, S. V, MOOK, R. A, DORSEY, G. F, HINER, R. N, CRIBBS, C. M, WHEELER, T. N, RAY, J. A, ANDREWS, R. C

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