Search Results - "TINWELL, H"

Isoflucypram: Combining in vivo and NAMs data in a weight of evidence approach to demonstrate the human non-relevance of the mode of action leading to the subtle thyroid effects observed in the rat by Tinwell, H., Bars, R.

“…Isoflucypram (ISY) is a new cereal fungicide with an overall favorable toxicity profile. As the thyroid was identified as a target organ only in the rat,…”
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Gene regulation by morpholines and piperidines in the cardiac embryonic stem cell test by Mennen, R.H., Hallmark, N., Pallardy, M., Bars, R., Tinwell, H., Piersma, A.H.

“…The cardiac embryonic stem cell test (ESTc) is an in vitro embryotoxicity screen which uses cardiomyocyte formation as the main differentiation route. Studies…”
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Evaluating H295R steroidogenesis assay data for robust interpretation by Tinwell, H., Karmaus, A., Gaskell, V., Gomes, C., Grant, C., Holmes, T., Jonas, A., Kellum, S., Krüger, K., Malley, L., Melching-Kollmuss, S., Mercier, O., Pandya, H., Placke, T., Settivari, R., De Waen, B.

“…The in vitro H295R steroidogenesis assay (OECD TG 456) is used to determine a chemical's potential to interfere with steroid hormone synthesis/metabolism. As…”
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The screening of everyday life chemicals in validated assays targeting the pituitary–gonadal axis by Tinwell, H., Colombel, S., Blanck, O., Bars, R.

“…•Ten structurally diverse chemicals were screened for endocrine activity.•The chemicals were judged intrinsic to modern life with unknown endocrine…”
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Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation by Tinwell, H., Rouquié, D., Schorsch, F., Geter, D., Wason, S., Bars, R.

“…•The MOA of fluopyram-induced liver tumors was investigated in the female rat.•CAR/PXR nuclear receptor activation was shown to be the first key event of the…”
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Genome-wide expression screening in the cardiac embryonic stem cell test shows additional differentiation routes that are regulated by morpholines and piperidines by Mennen, R.H., Hallmark, N., Pallardy, M., Bars, R., Tinwell, H., Piersma, A.H.

“…•The cardiac embryonic stem cell test showed additional differentiation routes.•Morpholines and piperidines regulated the alternative differentiation…”
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Molecular neural crest cell markers enable discrimination of organophosphates in the murine cardiac embryonic stem cell test by Mennen, R.H., Hallmark, N., Pallardy, M., Bars, R., Tinwell, H., Piersma, A.H.

“…[Display omitted] •Organophosphates induced distinctive effects on neural crest cells within the ESTc.•Neural crest gene transcripts were of added value to the…”
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Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors by Rouquié, D., Tinwell, H., Blanck, O., Schorsch, F., Geter, D., Wason, S., Bars, R.

“…•The MOA of fluopyram-induced thyroid tumors was investigated in the male mouse.•CAR/PXR nuclear receptor activation was shown to be the first key event of the…”
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Uterotrophic Activity of Bisphenol A in the Immature Rat by Ashby, J., Tinwell, H.

“…Bisphenol A (BPA) is active in immature AP rat uterotrophic assays when evaluated using either the oral or the subcutaneous (sc) injection routes of exposure…”
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Lack of Effects for Low Dose Levels of Bisphenol A and Diethylstilbestrol on the Prostate Gland of CF1 Mice Exposed in Utero by Ashby, John, Tinwell, H., Haseman, J.

“…vom Saal et al. (Proc. Natl. Acad. Sci. 94, 2056–2061, 1997) have reported that low dose exposure (0.02–2 μg/kg/day) of CF1 mice to diethylstilbestrol (DES) in…”
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Low dose evaluation of the antiandrogen flutamide following a Mode of Action approach by Sarrabay, A., Hilmi, C., Tinwell, H., Schorsch, F., Pallardy, M., Bars, R., Rouquié, D.

“…The dose–response characterization of endocrine mediated toxicity is an on-going debate which is controversial when exploring the nature of the dose–response…”
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Normal Sexual Development of Two Strains of Rat Exposed in Utero to Low Doses of Bisphenol A by Tinwell, H., Haseman, J., Lefevre, P. A., Wallis, N., Ashby, J.

“…Pregnant Sprague-Dawley (SD) and Alderley Park (Wistar derived) rats were exposed by gavage during gestation days 6–21 to 20 μg/kg, 100 μg/kg, or 50 mg/kg body…”
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Isoflucypram: A new fungicide with no thyroid related endocrine disrupting properties and an overall favorable mammalian safety profile by Tinwell, H.

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P03-03 Quantitative in vitro to in vivo extrapolation (QIVIVE) for liver-induced thyroid toxicity risk assessment by Lopez-Zazueta, C., Tinwell, H.

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A novel method for measuring aromatase activity in tissue samples by determining estradiol concentrations by Tinwell, H., Rascle, J. B., Colombel, S., Al Khansa, I., Freyberger, A., Bars, R.

“…ABSTRACT Increasing scrutiny of endocrine disrupters has led to changes to European pesticide and biocide legislation and to the introduction of the Endocrine…”
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The Effect on Sperm Production in Adult Sprague-Dawley Rats Exposed by Gavage to Bisphenol A between Postnatal Days 91–97 by Ashby, J., Tinwell, H., Lefevre, P. A., Joiner, R., Haseman, J.

“…M. Sakaue et al. (2001,J. Occup. Health vol. 43, pp. 185–190) have described how oral exposure of sexually mature male rats to bisphenol A (BPA) between…”
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Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities by Ashby, John, Tinwell, Helen, Odum, Jenny, Lefevre, Paul

“…While defining the no effect level for the 5α-reductase inhibitor finasteride in the Hershberger assay, we encountered an inverted-U low-dose trophic effect on…”
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P01-29 Assessment of in vitro approaches to identify succinate dehydrogenase inhibitors by Stinchcombe, S., Cowie, D., Tinwell, H.

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Effect of rodent diets on the sexual development of the rat by ODUM, J, TINWELL, H, JONES, K, VAN MILLER, J. P, JOINER, R. L, TOBIN, G, KAWASAKI, H, DEGHENGHI, R, ASHBY, J

“…Five rodent diets have been evaluated for their possible effect on the sexual development of the rat. Groups of 12 pregnant Alpk rats were fed one of the…”
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Correlation between Protein Accumulation Profiles and Conventional Toxicological Findings Using a Model Antiandrogenic Compound, Flutamide by Friry-Santini, Claire, Rouquié, David, Kennel, Philippe, Tinwell, Helen, Benahmed, Mohamed, Bars, Rémi

“…In conventional rodent toxicity studies the characterization of the adverse effects of a chemical relies primarily on gravimetric, and histopathological data…”
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