Search Results - "TINKER, A"

The Core Gut Microbiome of the American Cockroach, Periplaneta americana, Is Stable and Resilient to Dietary Shifts by Tinker, Kara A, Ottesen, Elizabeth A

“…The omnivorous cockroach Periplaneta americana hosts a diverse hindgut microbiota encompassing hundreds of microbial species. In this study, we used 16S rRNA…”
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Differences in Gut Microbiome Composition Between Sympatric Wild and Allopatric Laboratory Populations of Omnivorous Cockroaches by Tinker, Kara A, Ottesen, Elizabeth A

“…Gut microbiome composition is determined by a complex interplay of host genetics, founder's effects, and host environment. We are using omnivorous cockroaches…”
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Using genotyping-by-sequencing (GBS) for genomic discovery in cultivated oat by Huang, Yung-Fen, Poland, Jesse A, Wight, Charlene P, Jackson, Eric W, Tinker, Nicholas A

“…Advances in next-generation sequencing offer high-throughput and cost-effective genotyping alternatives, including genotyping-by-sequencing (GBS). Results have…”
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Differential expression and global analysis of miR156/SQUAMOSA promoter binding-like proteins (SPL) module in oat by Mehtab-Singh, Tripathi, Rajiv K., Bekele, Wubishet A., Tinker, Nicholas A., Singh, Jaswinder

“…SQUAMOSA promoter binding-like proteins (SPLs) are important transcription factors that influence growth phase transition and reproduction in plants. SPLs are…”
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The hindgut microbiota of praying mantids is highly variable and includes both prey-associated and host-specific microbes by Tinker, Kara A, Ottesen, Elizabeth A

“…Praying mantids are predators that consume a wide variety of insects. While the gut microbiome of carnivorous mammals is distinct from that of omnivores and…”
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Disentangling hindgut metabolism in the American cockroach through single-cell genomics and metatranscriptomics by Dukes, Helen E, Tinker, Kara A, Ottesen, Elizabeth A

“…Omnivorous cockroaches host a complex hindgut microbiota comprised of insect-specific lineages related to those found in mammalian omnivores. Many of these…”
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Genomic insights from the first chromosome-scale assemblies of oat (Avena spp.) diploid species by Maughan, Peter J, Lee, Rebekah, Walstead, Rachel, Vickerstaff, Robert J, Fogarty, Melissa C, Brouwer, Cory R, Reid, Robert R, Jay, Jeremy J, Bekele, Wubishet A, Jackson, Eric W, Tinker, Nicholas A, Langdon, Tim, Schlueter, Jessica A, Jellen, Eric N

“…Cultivated hexaploid oat (Common oat; Avena sativa) has held a significant place within the global crop community for centuries; although its cultivation has…”
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Whole genome and transcriptome analysis enhances precision cancer treatment options by Pleasance, E., Bohm, A., Williamson, L.M., Nelson, J.M.T., Shen, Y., Bonakdar, M., Titmuss, E., Csizmok, V., Wee, K., Hosseinzadeh, S., Grisdale, C.J., Reisle, C., Taylor, G.A., Lewis, E., Jones, M.R., Bleile, D., Sadeghi, S., Zhang, W., Davies, A., Pellegrini, B., Wong, T., Bowlby, R., Chan, S.K., Mungall, K.L., Chuah, E., Mungall, A.J., Moore, R.A., Zhao, Y., Deol, B., Fisic, A., Fok, A., Regier, D.A., Weymann, D., Schaeffer, D.F., Young, S., Yip, S., Schrader, K., Levasseur, N., Taylor, S.K., Feng, X., Tinker, A., Savage, K.J., Chia, S., Gelmon, K., Sun, S., Lim, H., Renouf, D.J., Jones, S.J.M., Marra, M.A., Laskin, J.

“…Recent advances are enabling delivery of precision genomic medicine to cancer clinics. While the majority of approaches profile panels of selected genes or…”
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Creativity in later life by Price, K.A, Tinker, A.M

“…Abstract The ageing population presents significant challenges for the provision of social and health services. Strategies are needed to enable older people to…”
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Genetic mapping of the powdery mildew resistance gene Pm7 on oat chromosome 5D by Brodführer, Sophie, Mohler, Volker, Stadlmeier, Melanie, Okoń, Sylwia, Beuch, Steffen, Mascher, Martin, Tinker, Nicholas A., Bekele, Wubishet A., Hackauf, Bernd, Herrmann, Matthias Heinrich

“…Key message Three independent experiments with different genetic backgrounds mapped the resistance gene Pm7 in the oat genome to the distal part of the long…”
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Loss‐of‐function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype by Maruthappu, T., Posafalvi, A., Castelletti, S., Delaney, P.J., Syrris, P., O'Toole, E.A., Green, K.J., Elliott, P.M., Lambiase, P.D., Tinker, A., McKenna, W.J., Kelsell, D.P.

“…Summary Background Arrhythmogenic cardiomyopathy (AC) is an inherited, frequently underdiagnosed disorder, which can predispose individuals to sudden cardiac…”
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Phylogenetic relationships in the genus Avena based on the nuclear Pgk1 gene by Peng, Yuanying, Zhou, Pingping, Zhao, Jun, Li, Junzhuo, Lai, Shikui, Tinker, Nicholas A, Liao, Shu, Yan, Honghai

“…The phylogenetic relationships among 76 Avena taxa, representing 14 diploids, eight tetraploids, and four hexaploids were investigated by using the nuclear…”
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Population genomics of Mediterranean oat (A. sativa) reveals high genetic diversity and three loci for heading date by Canales, F. J., Montilla-Bascón, G., Bekele, W. A., Howarth, C. J., Langdon, T., Rispail, N., Tinker, N. A., Prats, E.

“…Key message Genomic analysis of Mediterranean oats reveals high genetic diversity and three loci for adaptation to this environment. This information together…”
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Haplotag: Software for Haplotype-Based Genotyping-by-Sequencing Analysis by Tinker, Nicholas A, Bekele, Wubishet A, Hattori, Jiro

“…Genotyping-by-sequencing (GBS), and related methods, are based on high-throughput short-read sequencing of genomic complexity reductions followed by discovery…”
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Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199) by Tinker, A.V, Ellard, S, Welch, S, Moens, F, Allo, G, Tsao, M.S, Squire, J, Tu, D, Eisenhauer, E.A, MacKay, H

“…Abstract Objective HPV infection has been associated with deregulation of the PI3K-Akt-mTOR pathway in invasive cervical carcinomas. This 2-stage phase II…”
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Population structure and linkage disequilibrium in oat (Avena sativa L.): implications for genome-wide association studies by Newell, M. A, Cook, D, Tinker, N. A, Jannink, J.-L

“…The level of population structure and the extent of linkage disequilibrium (LD) can have large impacts on the power, resolution, and design of genome-wide…”
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Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy by Ng, K. E., Delaney, P. J., Thenet, D., Murtough, S., Webb, C. M., Zaman, N., Tsisanova, E., Mastroianni, G., Walker, S. L. M., Westaby, J. D., Pennington, D. J., Pink, R., Kelsell, D. P., Tinker, A.

“…The study of a desmoglein 2 murine model of arrhythmogenic cardiomyopathy revealed cardiac inflammation as a key early event leading to fibrosis…”
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Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance by He, Y, Wu, A C, Harrington, B S, Davies, C M, Wallace, S J, Adams, M N, Palmer, J S, Roche, D K, Hollier, B G, Westbrook, T F, Hamidi, H, Konecny, G E, Winterhoff, B, Chetty, N P, Crandon, A J, Oliveira, N B, Shannon, C M, Tinker, A V, Gilks, C B, Coward, J I, Lumley, J W, Perrin, L C, Armes, J E, Hooper, J D

“…Hematogenous metastases are rarely present at diagnosis of ovarian clear cell carcinoma (OCC). Instead dissemination of these tumors is characteristically via…”
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Multivariate Genome-Wide Association Analyses Reveal the Genetic Basis of Seed Fatty Acid Composition in Oat ( Avena sativa L.) by Carlson, Maryn O, Montilla-Bascon, Gracia, Hoekenga, Owen A, Tinker, Nicholas A, Poland, Jesse, Baseggio, Matheus, Sorrells, Mark E, Jannink, Jean-Luc, Gore, Michael A, Yeats, Trevor H

“…Oat ( L.) has a high concentration of oils, comprised primarily of healthful unsaturated oleic and linoleic fatty acids. To accelerate oat plant breeding…”
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Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations by Kapoor, R. R., Flanagan, S. E., James, C. T., McKiernan, J., Thomas, A. M., Harmer, S. C., Shield, J. P., Tinker, A., Ellard, S., Hussain, K.

“…Aims/hypothesis Dominantly acting loss-of-function mutations in the ABCC8/KCNJ11 genes can cause mild medically responsive hyperinsulinaemic hypoglycaemia…”
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