Search Results - "TINELLI, Stella"

Highly tumorigenic lung cancer CD133⁺ cells display stem-like features and are spared by cisplatin treatment by Bertolini, Giulia, Roz, Luca, Perego, Paola, Tortoreto, Monica, Fontanella, Enrico, Gatti, Laura, Pratesi, Graziella, Fabbri, Alessandra, Andriani, Francesca, Tinelli, Stella, Roz, Elena, Caserini, Roberto, Lo Vullo, Salvatore, Camerini, Tiziana, Mariani, Luigi, Delia, Domenico, Calabrò, Elisa, Pastorino, Ugo, Sozzi, Gabriella

“…The identification of lung tumor-initiating cells and associated markers may be useful for optimization of therapeutic approaches and for predictive and…”
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miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKCε and ZEB1 inhibition by El Bezawy, Rihan, Tinelli, Stella, Tortoreto, Monica, Doldi, Valentina, Zuco, Valentina, Folini, Marco, Stucchi, Claudio, Rancati, Tiziana, Valdagni, Riccardo, Gandellini, Paolo, Zaffaroni, Nadia

“…Radiotherapy is one of the main treatment options for non-metastatic prostate cancer (PCa). Although treatment technical optimization has greatly improved…”
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Design of Disruptors of the Hsp90-Cdc37 Interface by D'Annessa, Ilda, Hurwitz, Naama, Pirota, Valentina, Beretta, Giovanni Luca, Tinelli, Stella, Woodford, Mark, Freccero, Mauro, Mollapour, Mehdi, Zaffaroni, Nadia, Wolfson, Haim, Colombo, Giorgio

“…The molecular chaperone Hsp90 is a ubiquitous ATPase-directed protein responsible for the activation and structural stabilization of a large clientele of…”
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Targeting of the Lipid Metabolism Impairs Resistance to BRAF Kinase Inhibitor in Melanoma by Vergani, Elisabetta, Beretta, Giovanni L., Aloisi, Mariachiara, Costantino, Matteo, Corno, Cristina, Frigerio, Simona, Tinelli, Stella, Dugo, Matteo, Accattatis, Felice Maria, Granata, Agnese, Arnaboldi, Lorenzo, Rodolfo, Monica, Perego, Paola, Gatti, Laura

“…Drug resistance limits the achievement of persistent cures for the treatment of melanoma, in spite of the efficacy of the available drugs. The aim of the…”
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SPOP Deregulation Improves the Radiation Response of Prostate Cancer Models by Impairing DNA Damage Repair by El Bezawy, Rihan, Tripari, Martina, Percio, Stefano, Cicchetti, Alessandro, Tortoreto, Monica, Stucchi, Claudio, Tinelli, Stella, Zuco, Valentina, Doldi, Valentina, Gandellini, Paolo, Valdagni, Riccardo, Zaffaroni, Nadia

“…Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is the most commonly mutated gene in prostate cancer (PCa). Recent evidence reports a role…”
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Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds by Benedetti, Valentina, Perego, Paola, Luca Beretta, Giovanni, Corna, Elisabetta, Tinelli, Stella, Righetti, Sabina Carla, Leone, Roberto, Apostoli, Piero, Lanzi, Cinzia, Zunino, Franco

“…Because cytotoxic stress elicits various signaling pathways that may be implicated in cell survival or cell death, their alterations may have relevance in the…”
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Antiproliferative effects on human tumor cells and rat aortic smooth muscular cells of 2,3-heteroarylmaleimides and heterofused imides by Ferri, Nicola, Beccalli, Egle Maria, Contini, Alessandro, Corsini, Alberto, Antonino, Manuela, Radice, Tiziano, Pratesi, Graziella, Tinelli, Stella, Zunino, Franco, Gelmi, Maria Luisa

“…A series of 2,3-heteroarylmaleimides and polyheterocondensed imides were prepared and their antiproliferative activity was tested against human tumor cells…”
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Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells by Perego, Paola, Gatti, Laura, Righetti, Sabina C., Beretta, Giovanni L., Carenini, Nives, Corna, Elisabetta, Bo, Laura Dal, Tinelli, Stella, Colangelo, Donato, Leone, Roberto, Apostoli, Piero, Lombardi, Luciano, Beggiolin, Gino, Piazzoni, Laura, Zunino, Franco

“…BBR3464 is a trinuclear platinum complex that exhibits a potent cytotoxicity and efficacy against cisplatin‐resistant tumors. To better understand the…”
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Topoisomerase poisoning activity of novel disaccharide anthracyclines by Guano, F, Pourquier, P, Tinelli, S, Binaschi, M, Bigioni, M, Animati, F, Manzini, S, Zunino, F, Kohlhagen, G, Pommier, Y, Capranico, G

“…Doxorubicin and idarubicin are very effective anticancer drugs in the treatment of human hematological malignancies and solid tumors. These agents are well…”
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Abstract 1899: Extracellular lipid starvation modulates the effects of BRAF inhibitors in melanoma by Beretta, Giovanni L., Vergani, Elisabetta, Corno, Cristina, Tinelli, Stella, Rodolfo, Monica, Gatti, Laura, Perego, Paola

“…Melanoma is the most aggressive of all skin cancers, being the leading cause of death for cutaneous malignancy, with elevated metastatic spread and drug…”
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Transforming the Chemical Structure and Bio‐Nano Activity of Doxorubicin by Ultrasound for Selective Killing of Cancer Cells by Bhangu, Sukhvir Kaur, Fernandes, Soraia, Beretta, Giovanni Luca, Tinelli, Stella, Cassani, Marco, Radziwon, Agata, Wojnilowicz, Marcin, Sarpaki, Sophia, Pilatis, Irinaios, Zaffaroni, Nadia, Forte, Giancarlo, Caruso, Frank, Ashokkumar, Muthupandian, Cavalieri, Francesca

“…Reconfiguring the structure and selectivity of existing chemotherapeutics represents an opportunity for developing novel tumor‐selective drugs. Here, as a…”
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Deregulated FASN Expression in BRAF Inhibitor-Resistant Melanoma Cells Unveils New Targets for Drug Combinations by Stamatakos, Serena, Beretta, Giovanni Luca, Vergani, Elisabetta, Dugo, Matteo, Corno, Cristina, Corna, Elisabetta, Tinelli, Stella, Frigerio, Simona, Ciusani, Emilio, Rodolfo, Monica, Perego, Paola, Gatti, Laura

“…Metabolic changes promoting cell survival are involved in metastatic melanoma progression and in the development of drug resistance. In BRAF-inhibitor…”
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Abstract A032: miR-205 reconstitution sensitizes prostate cancer cells and xenografts to radiotherapy, through PKCε suppression by Gandellini, Paolo, Bezawy, Rihan El, Folini, Marco, Cominetti, Denis, Tinelli, Stella, Rancati, Tiziana, Valdagni, Riccardo, Zaffaroni, Nadia

“…Radiotherapy is a standard treatment for organ-confined prostate cancer (PCa). Although treatment technical optimization has greatly improved local tumor…”
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Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisons 1 1Edited by J. Karn by Borgnetto, M.Evelina, Tinelli, Stella, Carminati, Laura, Capranico, Giovanni

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Redox-Sensitive PEG–Polypeptide Nanoporous Particles for Survivin Silencing in Prostate Cancer Cells by Cavalieri, Francesca, Beretta, Giovanni L, Cui, Jiwei, Braunger, Julia A, Yan, Yan, Richardson, Joseph J, Tinelli, Stella, Folini, Marco, Zaffaroni, Nadia, Caruso, Frank

“…We report the engineering of intracellular redox-responsive nanoporous poly­(ethylene glycol)–poly­(l-lysine) particles (NPEG–PLLs). The obtained particles…”
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Design, modeling, synthesis and biological activity evaluation of camptothecin-linked platinum anticancer agents by Cincinelli, Raffaella, Musso, Loana, Dallavalle, Sabrina, Artali, Roberto, Tinelli, Stella, Colangelo, Donato, Zunino, Franco, De Cesare, Michelandrea, Beretta, Giovanni Luca, Zaffaroni, Nadia

“…The design, modeling, synthesis and biological activity evaluation of two hybrid agents formed by 7-oxyiminomethylcamptothecin derivatives and…”
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Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development by Capranico, G, Tinelli, S, Austin, C A, Fisher, M L, Zunino, F

“…The expression of DNA topoisomerase II alpha and beta genes was studied in murine normal tissues. Northern blot analysis using probes specific for the two…”
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Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition by Perego, Paola, Cossa, Giacomo, Tinelli, Stella, Corna, Elisabetta, Carenini, Nives, Gatti, Laura, De Cesare, Michelandrea, Ciusani, Emilio, Zunino, Franco, Luison, Elena, Canevari, Silvana, Zaffaroni, Nadia, Beretta, Giovanni Luca

“…Tyrosyl-DNA phosphodiesterase 1 (TDP1) plays a unique function as it catalyzes the repair of topoisomerase I-mediated DNA damage. Thus, ovarian carcinoma cell…”
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miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKC[epsilon] and ZEB1 inhibition by El Bezawy, Rihan, Tinelli, Stella, Tortoreto, Monica, Doldi, Valentina, Zuco, Valentina, Folini, Marco, Stucchi, Claudio, Rancati, Tiziana, Valdagni, Riccardo, Gandellini, Paolo, Zaffaroni, Nadia

“…Background Radiotherapy is one of the main treatment options for non-metastatic prostate cancer (PCa). Although treatment technical optimization has greatly…”
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Unravelling "off-target" effects of redox-active polymers and polymer multilayered capsules in prostate cancer cells by Beretta, Giovanni L, Folini, Marco, Cavalieri, Francesca, Yan, Yan, Fresch, Enrico, Kaliappan, Subramanian, Hasenöhrl, Christoph, Richardson, Joseph J, Tinelli, Stella, Fery, Andreas, Caruso, Frank, Zaffaroni, Nadia

“…Redox-active polymers and carriers are oxidizing nanoagents that can potentially trigger intracellular off-target effects. In the present study, we…”
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