Search Results - "TINDALL, Donald J"

Dynamic FoxO transcription factors by Huang, Haojie, Tindall, Donald J

“…Forkhead box O (FoxO) transcription factors FoxO1, FoxO3a, FoxO4 and FoxO6, the mammalian orthologs of Caenorhabditis elegans DAF-16, are emerging as an…”
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Alternatively spliced androgen receptor variants by Dehm, Scott M, Tindall, Donald J

“…Alternative splicing is an important mechanism for increasing functional diversity from a limited set of genes. Deregulation of this process is common in…”
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Regulation of FOXO protein stability via ubiquitination and proteasome degradation by Huang, Haojie, Tindall, Donald J.

“…Forkhead box O-class (FOXO) proteins are evolutionally conserved transcription factors. They belong to a family of proteins consisting of FOXO1, FOXO3a, FOXO4…”
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Androgen Receptor Rediscovered: The New Biology and Targeting the Androgen Receptor Therapeutically by RYAN, Charles J, TINDALL, Donald J

“…Discoveries over the past decade suggest that castration-resistant prostate cancer (CRPC) is sensitive, but not resistant to, further manipulation of the…”
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Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex by Heemers, Hannelore V, Tindall, Donald J

“…Androgens, acting through the androgen receptor (AR), are responsible for the development of the male phenotype during embryogenesis, the achievement of sexual…”
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Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer by Lamont, Kristin R, Tindall, Donald J

“…The development of stronger, more specific therapies for castration-recurrent prostate cancer depends upon gaining a more complete understanding of…”
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Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer by He, Yundong, Lu, Ji, Ye, Zhenqing, Hao, Siyuan, Wang, Liewei, Kohli, Manish, Tindall, Donald J, Li, Benyi, Zhu, Runzhi, Wang, Liguo, Huang, Haojie

“…Abstract Androgen receptor (AR) splice variants (ARVs) are implicated in development of castration-resistant prostate cancer (CRPC). Upregulation of ARVs often…”
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Are androgen receptor variants a substitute for the full-length receptor? by Lu, Ji, der Steen, Travis Van, Tindall, Donald J.

“…Key Points Truncated androgen receptor splice variants (AR-Vs) can resist androgen deprivation therapy AR-Vs have an important role in the progression of…”
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Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer by Dehm, Scott M, Tindall, Donald J

“…The androgen receptor (AR) is a nuclear receptor transcription factor that mediates the cellular actions of androgens, the male sex steroids…”
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Molecular regulation of androgen action in prostate cancer by Dehm, Scott M., Tindall, Donald J.

“…Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the…”
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Effect of Dutasteride on the Risk of Prostate Cancer by Andriole, Gerald L, Bostwick, David G, Brawley, Otis W, Gomella, Leonard G, Marberger, Michael, Montorsi, Francesco, Pettaway, Curtis A, Tammela, Teuvo L, Teloken, Claudio, Tindall, Donald J, Somerville, Matthew C, Wilson, Timothy H, Fowler, Ivy L, Rittmaster, Roger S

“…Dutasteride, an inhibitor of 5α-reductase in the prostate, was tested in a large, randomized trial to determine its ability to prevent prostate cancer. Over…”
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Posttranslational modification of the androgen receptor in prostate cancer by van der Steen, Travis, Tindall, Donald J, Huang, Haojie

“…The androgen receptor (AR) is important in the development of the prostate by regulating transcription, cellular proliferation, and apoptosis. AR undergoes…”
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Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer by Zhao, Yu, Wang, Liguo, Ren, Shancheng, Wang, Lan, Blackburn, Patrick R., McNulty, Melissa S., Gao, Xu, Qiao, Meng, Vessella, Robert L., Kohli, Manish, Zhang, Jun, Karnes, R. Jeffrey, Tindall, Donald J., Kim, Youngsoo, MacLeod, Robert, Ekker, Stephen C., Kang, Tiebang, Sun, Yinghao, Huang, Haojie

“…The androgen receptor (AR) is required for castration-resistant prostate cancer (CRPC) progression, but the function and disease relevance of AR-bound…”
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Mechanisms of Androgen-Refractory Prostate Cancer by Debes, Jose D, Tindall, Donald J

“…Prostate cancer is the second-leading cause of cancer-related death among men and the seventh most common cause of death in the United States overall. Most…”
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Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation by Spratt, Daniel E, Evans, Michael J, Davis, Brian J, Doran, Michael G, Lee, Man Xia, Shah, Neel, Wongvipat, John, Carnazza, Kathryn E, Klee, George G, Polkinghorn, William, Tindall, Donald J, Lewis, Jason S, Sawyers, Charles L

“…Clinical trials have established the benefit of androgen deprivation therapy (ADT) combined with radiotherapy in prostate cancer. ADT sensitizes prostate…”
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CDK2-Dependent Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage by Huang, Haojie, Regan, Kevin M., Lou, Zhenkun, Chen, Junjie, Tindall, Donald J.

“…The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage--induced cell…”
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Androgen receptor: past, present and future by Schmidt, Lucy J, Tindall, Donald J

“…Androgens and the androgen receptor have been the focus of prostate cancer research since the early 1940s, when Huggins and Hodges demonstrated that removal of…”
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Global Methylation Profiling for Risk Prediction of Prostate Cancer by MAHAPATRA, Saswati, KLEE, Eric W, YOUNG, Charles Y. F, ZHIFU SUN, JIMENEZ, Rafael E, KLEE, George G, TINDALL, Donald J, VANAJA DONKENA, Krishna

“…The aim of this study was to investigate the promoter hypermethylation as diagnostic markers to detect malignant prostate cells and as prognostic markers to…”
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Skp2 Inhibits FOXO1 in Tumor Suppression through Ubiquitin-Mediated Degradation by Huang, Haojie, Regan, Kevin M., Wang, Fang, Wang, Diping, Smith, David I., Jan M. A. van Deursen, Tindall, Donald J., Hershko, Avram

“…Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis…”
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New Developments in the Medical Management of Prostate Cancer by Kohli, Manish, MD, Tindall, Donald J., PhD

“…Prostate cancer is a substantial public health burden and a leading cause of cancer—related morbidity and mortality in the United States despite the…”
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