Search Results - "TIMOTHY, K"

Engineered Living Hydrogels by Liu, Xinyue, Inda, Maria Eugenia, Lai, Yong, Lu, Timothy K., Zhao, Xuanhe

“…Living biological systems, ranging from single cells to whole organisms, can sense, process information, and actuate in response to changing environmental…”
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Development and Challenges of Antimicrobial Peptides for Therapeutic Applications by Chen, Charles H, Lu, Timothy K

“…More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have been approved by the U.S. Food and Drug Administration (FDA). Now…”
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Genomically encoded analog memory with precise in vivo DNA writing in living cell populations by Farzadfard, Fahim, Lu, Timothy K.

“…Cellular memory is crucial to many natural biological processes and sophisticated synthetic biology applications. Existing cellular memories rely on epigenetic…”
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Synthetic circuits integrating logic and memory in living cells by Siuti, Piro, Yazbek, John, Lu, Timothy K

“…A toolbox for rapidly creating synthetic circuits that respond to past and present inputs opens new doors for cellular engineering. Logic and memory are…”
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Architectural design drives the biogeography of indoor bacterial communities by Kembel, Steven W, Meadow, James F, O'Connor, Timothy K, Mhuireach, Gwynne, Northcutt, Dale, Kline, Jeff, Moriyama, Maxwell, Brown, G Z, Bohannan, Brendan J M, Green, Jessica L

“…Architectural design has the potential to influence the microbiology of the built environment, with implications for human health and well-being, but the…”
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Relationships between phyllosphere bacterial communities and plant functional traits in a neotropical forest by Kembel, Steven W., O'Connor, Timothy K., Arnold, Holly K., Hubbell, Stephen P., Wright, S. Joseph, Green, Jessica L.

“…The phyllosphere—the aerial surfaces of plants, including leaves—is a ubiquitous global habitat that harbors diverse bacterial communities. Phyllosphere…”
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Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases by Citorik, Robert J, Mimee, Mark, Lu, Timothy K

“…Delivery of CRISPR-Cas nucleases using bacteriophage enables targeted killing of microbes in a population Current antibiotics tend to be broad spectrum,…”
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Emerging applications for DNA writers and molecular recorders by Farzadfard, Fahim, Lu, Timothy K

“…Natural life is encoded by evolvable, DNA-based memory. Recent advances in dynamic genome-engineering technologies, which we collectively refer to as in vivo…”
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Microbiome therapeutics — Advances and challenges by Mimee, Mark, Citorik, Robert J., Lu, Timothy K.

“…The microbial community that lives on and in the human body exerts a major impact on human health, from metabolism to immunity. In order to leverage the close…”
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Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells by Nissim, Lior, Perli, Samuel D., Fridkin, Alexandra, Perez-Pinera, Pablo, Lu, Timothy K.

“…RNA-based regulation and CRISPR/Cas transcription factors (CRISPR-TFs) have the potential to be integrated for the tunable modulation of gene networks. A major…”
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Progress in Top-Down Proteomics and the Analysis of Proteoforms by Toby, Timothy K, Fornelli, Luca, Kelleher, Neil L

“…From a molecular perspective, enactors of function in biology are intact proteins that can be variably modified at the genetic, transcriptional, or…”
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An overview on biodegradation of polystyrene and modified polystyrene: the microbial approach by Ho, Ba Thanh, Roberts, Timothy K, Lucas, Steven

“…Polystyrene is a widely used plastic in many aspects of human life and in industries due to its useful characteristics of low cost, light weight, ease of…”
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Genetically Engineered Phages: a Review of Advances over the Last Decade by Pires, Diana P, Cleto, Sara, Sillankorva, Sanna, Azeredo, Joana, Lu, Timothy K

“…Soon after their discovery in the early 20th century, bacteriophages were recognized to have great potential as antimicrobial agents, a potential that has yet…”
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Synthetic analog computation in living cells by Daniel, Ramiz, Rubens, Jacob R., Sarpeshkar, Rahul, Lu, Timothy K.

“…Synthetic analog gene circuits can be engineered to execute logarithmically linear sensing, addition, ratiometric and power-law computations in living cells…”
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Peptide Design Principles for Antimicrobial Applications by Torres, Marcelo D.T., Sothiselvam, Shanmugapriya, Lu, Timothy K., de la Fuente-Nunez, Cesar

“…The increased incidence of bacterial resistance to available antibiotics represents a major global health problem and highlights the need for novel…”
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Microbes as Biosensors by Inda, Maria Eugenia, Lu, Timothy K

“…The ability to detect disease early and deliver precision therapy would be transformative for the treatment of human illnesses. To achieve these goals,…”
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A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions by Khalil, Ahmad S., Lu, Timothy K., Bashor, Caleb J., Ramirez, Cherie L., Pyenson, Nora C., Joung, J. Keith, Collins, James J.

“…Eukaryotic transcription factors (TFs) perform complex and combinatorial functions within transcriptional networks. Here, we present a synthetic framework for…”
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The next generation of bacteriophage therapy by Lu, Timothy K, Koeris, Michael S

“…Highlights ► In this review, we give an overview of the current state-of-the-art of bacteriophage therapy. ► We review the challenges to be overcome before…”
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Single-Nucleotide-Resolution Computing and Memory in Living Cells by Farzadfard, Fahim, Gharaei, Nava, Higashikuni, Yasutomi, Jung, Giyoung, Cao, Jicong, Lu, Timothy K.

“…The ability to process and store information in living cells is essential for developing next-generation therapeutics and studying biology in situ. However,…”
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Dispersing biofilms with engineered enzymatic bacteriophage by Lu, Timothy K, Collins, James J

“…Synthetic biology involves the engineering of biological organisms by using modular and generalizable designs with the ultimate goal of developing useful…”
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