Search Results - "TIMMERS, K. I"

Multiple alterations in insulin responses to glucose in islets from 48-h glucose-infused nondiabetic rats by Timmers, K. I., Powell, A. M., Voyles, N. R., Solomon, D., Wilkins, S. D., Bhathena, S., Recant, L.

“…Multiple alterations in insulin responses to glucose in islets from 48-h glucose-infused nondiabetic rats. K I Timmers , A M Powell , N R Voyles , D Solomon ,…”
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Genetically obese rats with (SHR/N-cp) and without diabetes (LA/N-cp) share abnormal islet responses to glucose by Timmers, K I, Voyles, N R, Recant, L

“…To assess the effect of hyperglycemia on the function of islets obtained from obese rats, the behavior of isolated islets from LA/N-corpulent (nondiabetic…”
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Multiple alterations in insulin responses to glucose in islets from 48-h glucose-infused nondiabetic rats by TIMMERS, K. I, POWELL, A. M, VOYLES, N. R, SOLOMON, D, WILKINS, S. D, BHATENA, S, RECANT, L

“…To examine the biochemical mechanisms by which hyperglycemia produces insulin secretory abnormalities, we studied isolated islets from control rats and rats…”
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Reversible impairment of glucose-induced insulin secretion in SHR/N-cp rats: genetic model of type II diabetes by VOYLES, N. R, POWELL, A. M, TIMMERS, K. I, WILKINS, S. D, BHATHENA, S. J, HANSEN, C, MICHAELIS, O. E. IV, RECANT, L

“…The SHR/N-cp rat is a new genetically obese model for non-insulin-dependent diabetes mellitus. Expression of the diabetes is enhanced by a high-sucrose (54%)…”
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Comparison of insulin secretory patterns in obese nondiabetic LA/N-cp and obese diabetic SHR/N-cp rats: role of hyperglycemia by RECANT, L, VOYLES, N. R, TIMMERS, K. I, BHATHENA, S. J, SOLOMON, D, WILKINS, S, MICHAELIS, O. E. IV

“…Obese diabetic SHR/N-(cp/cp) rats are a genetic model for non-insulin-dependent diabetes mellitus. When SHR/N-cp rats are overtly diabetic, they are…”
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Reversible impairment of glucose-induced insulin secretion in SHR/N-cp rats. Genetic model of type II diabetes by N R Voyles, A M Powell, K I Timmers, S D Wilkins, S J Bhathena, C Hansen, O E Michaelis, 4th, L Recant

“…Reversible impairment of glucose-induced insulin secretion in SHR/N-cp rats. Genetic model of type II diabetes. N R Voyles , A M Powell , K I Timmers , S D…”
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Opioid peptides in rat islets of Langerhans: immunoreactive met- and leu-enkephalins and BAM-22P by TIMMERS, K. I, VOYLES, N. R, KING, C, WELLS, M, FAIRTILE, R, RECANT, L

“…Previous studies have shown that met- and leu-enkephalins are present in extracts of whole pancreas obtained from guinea pigs and human cadavers. The present…”
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Tissue somatostatin levels in three models of genetic obesity in rats by Voyles, N R, Bhathena, S J, Kennedy, B, Wilkins, S D, Michaelis, 4th, O E, Zalenski, C M, Timmers, K I, Recant, L

“…A potential role for somatostatin (SRIF) in the pathogenesis of the hyperinsulinemia of obese rats was considered. SRIF like immunoreactivity (ng/mg protein)…”
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Comparison of insulin secretory patterns in obese nondiabetic LA/N-cp and obese diabetic SHR/N-cp rats. Role of hyperglycemia by L Recant, N R Voyles, K I Timmers, S J Bhathena, D Solomon, S Wilkins, O E Michaelis, 4th

“…Comparison of insulin secretory patterns in obese nondiabetic LA/N-cp and obese diabetic SHR/N-cp rats. Role of hyperglycemia. L Recant , N R Voyles , K I…”
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Cytosolic insulin-degrading activity in islet-derived tumor cell lines and in normal rat islets by BHATHENA, S. J, TIMMERS, K. I, OIE, H. K, VOYLES, N. R, RECANT, L

“…RIN-m cells, cultured from a rat insulinoma, not only bind and secrete but also degrade insulin (Diabetes 1982; 31:521-31). The insulin-degrading activity…”
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Unique alterations of neuropeptide content in median eminence, amygdala, and dorsal vagal complex of 3- and 6-week-old diabetes mutant mice by Timmers, K I, Palkovits, M, Coleman, D L

“…The nature of the genetic defects which define the obese (ob) and diabetes (db) loci in mice remain unknown, but both produce similar syndromes when maintained…”
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Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein by Timmers, K I, Clark, A E, Omatsu-Kanbe, M, Whiteheart, S W, Bennett, M K, Holman, G D, Cushman, S W

“…The vesicle-associated membrane proteins [VAMPs; vesicle SNAP receptors (v-SNAREs)] present on GLUT4-enriched vesicles prepared from rat adipose cells [Cain,…”
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Copper deficiency in rats increases pancreatic enkephalin-containing peptides and insulin by Recant, L, Voyles, N R, Timmers, K I, Zalenski, C, Fields, M, Bhathena, S J

“…Free enkephalins (enk) and higher molecular weight enkephalin-containing peptides (enk-c-p) are present in the endocrine pancreas of rats, presumably in B…”
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Cytosolic insulin-degrading activity in islet-derived tumor cell lines and in normal rat islets by Bhathena, S. J., Timmers, K. I., Oie, H. K., Voyles, N. R., Recant, L.

“…Cytosolic insulin-degrading activity in islet-derived tumor cell lines and in normal rat islets. S J Bhathena , K I Timmers , H K Oie , N R Voyles and L Recant…”
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Decreased plasma enkephalins in copper deficiency in man by Bhathena, SJ, Recant, L, Voyles, NR, Timmers, KI, Reiser, S, Smith, JC, Powell, AS

“…Twenty-four male subjects participated in a study in which the effect of feeding diets low in copper ( l .03 mg/day) on plasma opiates was determined. The…”
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Developmental patterns for pancreatic opioids in the rat by POWELL, A. M, VOYLES, N. R, WILKINS, S. D, ZALENSKI, C. M, TIMMERS, K. I, RECANT, L

“…Developmental patterns for rat pancreatic opioid peptides and islet hormones were studied from gestational day 20 through adulthood. Fetal tissue was obtained…”
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Cell biology of insulin action on glucose transport by Cushman, W, Satoh, S, Timmers, K I, Malide, D, Holman, G D

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Impaired 6-phosphofructokinase activity in mononuclear leukocytes from patients with type II diabetes mellitus by Timmers, K I, Dons, R, Grunberger, G, Hodge, J

“…Seven cytoplasmic enzyme activities were measured in extracts of mononuclear leukocytes (lymphocytes plus monocytes) obtained from 19 type II diabetic humans…”
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Regulation of glucose-6-phosphate dehydrogenase activity during caloric restriction in human adipose tissue by Timmers, K I, Knittle, J L

“…Glucose-6-phosphate dehydrogenase activity was significantly lower in adipose tissue of human subjects after 7 days of severe caloric restriction on…”
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Circulating factors affect 6-phosphofructokinase activity in human adipose tissue by Timmers, K I, Katz, D P, Knittle, J L

“…6-Phosphofructokinase activity was lower in adipose tissue of obese, insulin-resistant subjects studied at stable body weight than in nonobese controls. This…”
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