Search Results - "TIMCHENKO, Nikolai A"

Help for Sick Kids: New Insights Into Hepatoblastoma by Timchenko, Nikolai A.

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Therapeutic Targeting of the GSK3β-CUGBP1 Pathway in Myotonic Dystrophy by Lutz, Maggie, Levanti, Miranda, Karns, Rebekah, Gourdon, Genevieve, Lindquist, Diana, Timchenko, Nikolai A, Timchenko, Lubov

“…Myotonic Dystrophy type 1 (DM1) is a neuromuscular disease associated with toxic RNA containing expanded CUG repeats. The developing therapeutic approaches to…”
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Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease by Jin, Jingling, Valanejad, Leila, Nguyen, Thuy Phuong, Lewis, Kyle, Wright, Mary, Cast, Ashley, Stock, Lauren, Timchenko, Lubov, Timchenko, Nikolai A.

“…The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of…”
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Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPα-p300 Axis by Nguyen, Phuong, Valanejad, Leila, Cast, Ashley, Wright, Mary, Garcia, Jose M., El-Serag, Hashem B., Karns, Rebekah, Timchenko, Nikolai A.

“…The aging liver is affected by several disorders, including steatosis, that can lead to a decline of liver functions. Here, we present evidence that the…”
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Intracellular signaling and hepatocellular carcinoma by Iakova, Polina, Timchenko, Lubov, Timchenko, Nikolai A

“…Abstract Liver cancer is the fifth most common cancer and the third most common cause of cancer related death in the world. The recent development of new…”
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The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation by Jin, Jingling, Iakova, Polina, Jiang, Yanjun, Medrano, Estela E., Timchenko, Nikolai A.

“…Age declines liver functions, leading to the development of age‐associated diseases. A member of the sirtuins family, SIRT1, is involved in the control of…”
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Alcohol Metabolism-mediated Oxidative Stress Down-regulates Hepcidin Transcription and Leads to Increased Duodenal Iron Transporter Expression by Harrison-Findik, Duygu Dee, Schafer, Denise, Klein, Elizabeth, Timchenko, Nikolai A., Kulaksiz, Hasan, Clemens, Dahn, Fein, Evelyn, Andriopoulos, Billy, Pantopoulos, Kostas, Gollan, John

“…Patients with alcoholic liver disease frequently exhibit iron overload in association with increased hepatic fibrosis. Even moderate alcohol consumption…”
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Increased Expression of Enzymes of Triglyceride Synthesis Is Essential for the Development of Hepatic Steatosis by Jin, Jingling, Iakova, Polina, Breaux, Meghan, Sullivan, Emily, Jawanmardi, Nicole, Chen, Dahu, Jiang, Yanjun, Medrano, Estela M., Timchenko, Nikolai A.

“…Molecular mechanisms underpinning nonalcoholic fatty liver disease (NAFLD) are not well understood. The earliest step of NAFLD is hepatic steatosis, which is…”
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Role of HDAC1 in senescence, aging, and cancer by Willis-Martinez, Danielle, Richards, Hunter W., Timchenko, Nikolai A., Medrano, Estela E.

“…HDAC1 is a member of the class I of histone deacetylases that also includes HDAC2, -3 and -8. Although HDAC1 has been mostly studied in the context of cancer,…”
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Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in mice by He, Quan, Wang, Fangfei, Honda, Takashi, Lindquist, Diana M, Dillman, Jonathan R, Timchenko, Nikolai A, Redington, Andrew N

“…Previous in vitro studies have demonstrated that miR-144 inhibits hepatocellular carcinoma cell proliferation, invasion, and migration. We have shown that…”
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Aging and liver regeneration by Timchenko, Nikolai A

“…The loss of regenerative capacity is the most dramatic age-associated alteration in the liver. Although this phenomenon was reported over 50 years ago, the…”
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Overexpression of CUG Triplet Repeat-binding Protein, CUGBP1, in Mice Inhibits Myogenesis by Timchenko, Nikolai A., Patel, Roma, Iakova, Polina, Cai, Zong-Jin, Quan, Ling, Timchenko, Lubov T.

“…Accumulation of RNA CUG repeats in myotonic dystrophy type 1 (DM1) patients leads to the induction of a CUG-binding protein, CUGBP1, which increases…”
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Mitochondrial and anabolic pathways in hepatocellular carcinoma by Timchenko, Nikolai A.

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Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate by Iakova, Polina, Wang, Guo-Li, Timchenko, Lubov, Michalak, Marek, Pereira-Smith, Olivia M, Smith, James R, Timchenko, Nikolai A

“…Induction of p21 in senescent human fibroblasts plays a key role in the inactivation of cyclin‐dependent kinases and the resulting irreversible growth arrest…”
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Increased CUG Triplet Repeat-binding Protein-1 Predisposes to Impaired Adipogenesis with Aging by Karagiannides, Iordanes, Thomou, Thomas, Tchkonia, Tamara, Pirtskhalava, Tamar, Kypreos, Kyriakos E., Cartwright, Andrew, Dalagiorgou, Georgia, Lash, Timothy L., Farmer, Stephen R., Timchenko, Nikolai A., Kirkland, James L.

“…Preadipocyte differentiation capacity declines between middle and old age. Expression of the adipogenic transcription factors, CCAAT/enhancer-binding protein…”
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SKI knockdown inhibits human melanoma tumor growth in vivo by Chen, Dahu, Lin, Qiushi, Box, Neil, Roop, Dennis, Ishii, Shunsuke, Matsuzaki, Koichi, Fan, Tao, Hornyak, Thomas J., Reed, Jon A, Stavnezer, Ed, Timchenko, Nikolai A., Medrano, Estela E.

“…Summary The SKI protein represses the TGF‐β tumor suppressor pathway by associating with the Smad transcription factors. SKI is upregulated in human malignant…”
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The Leukemic Fusion Gene AML1-MDS1-EVI1 Suppresses CEBPA in Acute Myeloid Leukemia by Activation of Calreticulin by Helbling, Daniel, Mueller, Beatrice U., Timchenko, Nikolai A., Hagemeijer, Anne, Jotterand, Martine, Meyer-Monard, Sandrine, Lister, Andrew, Rowley, Janet D., Huegli, Barbara, Fey, Martin F., Pabst, Thomas

“…The leukemic fusion gene AML1-MDS1-EVI1 (AME) encodes a chimeric transcription factor that results from the t(3,21)(q26;q22) translocation seen in patients…”
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Cell‐type specific functions of epidermal growth factor receptor are involved in development of hepatocellular carcinoma by Timchenko, Nikolai A.

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Generation of pediatric liver cancer patient–derived xenograft platforms for pediatric liver cancer: A critical stage in the development of anticancer treatments by Tiao, Gregory, Geller, James, Timchenko, Nikolai A.

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Reduction of Cellular Nucleic Acid Binding Protein Encoded by a Myotonic Dystrophy Type 2 Gene Causes Muscle Atrophy by Wei, Christina, Stock, Lauren, Schneider-Gold, Christiane, Sommer, Claudia, Timchenko, Nikolai A., Timchenko, Lubov

“…Myotonic dystrophy type 2 (DM2) is a neuromuscular disease caused by an expansion of intronic CCTG repeats in the CNBP gene, which encodes a protein regulating…”
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