Retro- and prospective evaluation of dynamics of some mutational events

Retro- and prospective evaluation of dynamics of some mutational events

The dynamics of some mutational events were studied in a Siberian town with a chemical industry. Retro- and prospective evaluations of the frequency of spontaneous abortions, multiple congenital malformations, and Down syndrome were carried out. Mutational components of these endpoints were summariz...

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Bibliographic Details
Published in:Human genetics Vol. 72; no. 1; pp. 77 - 79
Main Authors: BOCHKOV, N. P, GRIGORIAN, S. D, LUNGA, I. N, NIKOLAEVA, I. V, PRUSSAKOV, V. M, TIKHOPOY, M. V
Format: Journal Article
Language:English
Published: Heidelberg Springer 1986
Berlin
New York, NY
Subjects:
Abnormalities, Multiple - epidemiology
Abnormalities, Multiple - genetics
Abortion, Spontaneous - epidemiology
Abortion, Spontaneous - genetics
Biological and medical sciences
Down Syndrome - epidemiology
Down Syndrome - genetics
Female
General aspects. Genetic counseling
Humans
Infant, Newborn
Medical genetics
Medical sciences
Models, Genetic
Mutation
Pregnancy
Prospective Studies
Retrospective Studies
Siberia
Siberia
Human
Frequency
USSR
Mutation
Dynamics
Siberia
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Summary:The dynamics of some mutational events were studied in a Siberian town with a chemical industry. Retro- and prospective evaluations of the frequency of spontaneous abortions, multiple congenital malformations, and Down syndrome were carried out. Mutational components of these endpoints were summarized and provisionally termed "units of mutational events" (UME). The results show that the frequencies of UME have not changed in 14 years.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00278822