Search Results - "TIKELLIS, Chris"

Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease by Tikellis, Chris, Thomas, M. C.

“…Angiotensin-converting enzyme 2 (ACE2) shares some homology with angiotensin-converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of…”
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Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells by Okabe, Jun, Orlowski, Christian, Balcerczyk, Aneta, Tikellis, Chris, Thomas, Merlin C, Cooper, Mark E, El-Osta, Assam

“…RATIONALE:Epigenetic changes are implicated in the persisting vascular effects of hyperglycemia. The precise mechanism whereby chromatin structure and…”
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The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status by Garg, Mayur, Royce, Simon G., Tikellis, Chris, Shallue, Claire, Sluka, Pavel, Wardan, Hady, Hosking, Patrick, Monagle, Shaun, Thomas, Merlin, Lubel, John S., Gibson, Peter R.

“…Background: The intestinal vitamin D receptor (VDR) remains poorly characterized in patients with inflammatory bowel disease (IBD). Methods: Colonoscopic…”
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Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms by Cooper, Mark E, Tonna, Stephen, El-Osta, Assam, Tikellis, Chris

“…Chronic hyperglycemia is associated with the presence and evolution of diabetic complications in type 1 and type 2 diabetes. Intensive glycemic control can…”
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Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE-/- mice by Hanssen, Nordin M.J., Tikellis, Chris, Pickering, Raelene J., Dragoljevic, Dragana, Lee, Man Kit Sam, Block, Tomasz, Scheijen, Jean LJM, Wouters, Kristiaan, Miyata, Toshio, Cooper, Mark E., Murphy, Andrew J., Thomas, Merlin C., Schalkwijk, Casper G.

“…Methylglyoxal (MGO) is a reactive glucose metabolite linked to diabetic cardiovascular disease (CVD). MGO levels surge during intermittent hyperglycemia. We…”
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ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes by TIKELLIS, Chris, BIALKOWSKI, Katarzyna, PETE, Josepha, SHEEHY, Karen, QUI SU, JOHNSTON, Colin, COOPER, Mark E, THOMAS, Merlin C

“…ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes Chris Tikellis , Katarzyna Bialkowski , Josepha Pete , Karen Sheehy…”
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Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure by Komers, Radko, Oyama, Terry T., Beard, Douglas R., Tikellis, Chris, Xu, Bei, Lotspeich, Daniel F., Anderson, Sharon

“…Rho-associated kinases (ROCK) are activated in the kidney as well as in cultured cells of diabetic models and have been implicated in renal pathophysiology. To…”
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Short-term treatment with diminazene aceturate ameliorates the reduction in kidney ACE2 activity in rats with subtotal nephrectomy by Velkoska, Elena, Patel, Sheila K, Griggs, Karen, Pickering, Raelene J, Tikellis, Chris, Burrell, Louise M

“…Angiotensin converting enzyme (ACE) 2 is an important modulator of the renin angiotensin system (RAS) through its role to degrade angiotensin (Ang) II…”
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The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent by Sampson, Amanda K, Hilliard, Lucinda M, Moritz, Karen M, Thomas, Merlin C, Tikellis, Chris, Widdop, Robert E, Denton, Kate M

“…The complex role of the renin-angiotensin-system (RAS) in arterial pressure regulation has been well documented. Recently, we demonstrated that chronic…”
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Circulating Soluble ACE2 Plays an Independent Role to Protect against Vascular Damage in Diabetic Mice by Tikellis, Chris, Robinson, Gardner N, Rosado, Carlos J, Batu, Duygu, Zuniga-Gutierrez, Maria A, Pickering, Raelene J, Thomas, Merlin C

“…Circulating levels of soluble ACE2 are increased by diabetes. Although this increase is associated with the presence and severity of cardiovascular disease,…”
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Angiotensin-converting enzyme 2 is a key modulator of the renin–angiotensin system in cardiovascular and renal disease by Tikellis, Chris, Bernardi, Stella, Burns, Wendy C

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Direct antiatherosclerotic effects of PPAR agonists by Jandeleit-Dahm, Karin A M, Calkin, Anna, Tikellis, Chris, Thomas, Merlin

“…Peroxisome proliferator activated receptors (PPARs) are ligand-dependent transcription factors that mediate a range of important metabolic functions by…”
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Expression and function of ATIP/MTUS1 in human prostate cancer cell lines by Louis, Simon N.S., Chow, Laurie, Rezmann, Linda, Krezel, Michael A., Catt, Kevin J., Tikellis, Chris, Frauman, Albert G., Louis, William J.

“…BACKGROUND We have previously demonstrated Ang II type 2 (AT2‐) receptor‐mediated inhibition of EGF‐induced prostate cancer cell growth in androgen‐dependent…”
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Reduced tubular cation transport in diabetes: Prevented by ACE inhibition by Thomas, Merlin C., Tikellis, Chris, Burns, Wendy C., Thallas, Vicki, Forbes, Josephine M., Cao, Zemin, Osicka, Tanya M., Russo, Leileata M., Jerums, George, Ghabrial, Hany, Cooper, Mark E., Kantharidis, Phillip

“…Reduced tubular cation transport in diabetes: Prevented by ACE inhibition. The renal clearance of organic cations is important for the homeostasis of a number…”
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High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction by Kooptiwut, Suwattanee, Kebede, Melkam, Zraika, Sakeneh, Visinoni, Sherley, Aston-Mourney, Kathryn, Favaloro, Jenny, Tikellis, Chris, Thomas, Merlin C, Forbes, Josephine M, Cooper, Mark E, Dunlop, Marjorie, Proietto, Joseph, Andrikopoulos, Sofianos

“…Type 2 diabetes is characterized by islet dysfunction resulting in hyperglycemia, which can then lead to further deterioration in islet function. A possible…”
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Expression analysis of the epigenetic methyltransferases and Methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL) by Harikrishnan, KN, Sahar, Bassal, Tikellis, Chris, El-Osta, Assam

“…The importance of epigenetic modifications in carcinogenesis has been a source of controversy for some time. There is little doubt that changes in genomic…”
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Specialised Proresolving Mediators Protect the Diabetic Kidney Against Podocyte Loss: FR-PO368 by Kantharidis, Phillip, Bose, Madhura, Mohan, Muthukumar, Tikellis, Chris, Brennan, Eoin, Godson, Catherine, Cooper, Mark E.

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Angiotensin-converting enzyme 2 is a key modulator of the renin–angiotensin system in cardiovascular and renal disease by Tikellis, Chris, Bernardi, Stella, Burns, Wendy C

“…PURPOSE OF REVIEWAngiotensin-converting enzyme 2 (ACE2) has recently emerged as a key regulator of the renin–angiotensin system in both health and disease…”
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Protective Effect of let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis by Brennan, Eoin, Wang, Bo, McClelland, Aaron, Mohan, Muthukumar, Marai, Mariam, Beuscart, Ophelie, Derouiche, Sinda, Gray, Stephen, Pickering, Raelene, Tikellis, Chris, de Gaetano, Monica, Barry, Mary, Belton, Orina, Ali-Shah, Syed Tasadaque, Guiry, Patrick, Jandeleit-Dahm, Karin A M, Cooper, Mark E, Godson, Catherine, Kantharidis, Phillip

“…The let-7 miRNA family plays a key role in modulating inflammatory responses. Vascular smooth muscle cell (SMC) proliferation and endothelial cell (EC)…”
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ACE2 CONTRIBUTES TO THE NORMAL REGULATION OF ARTERIAL PRESSURE AND IMMUNITY IN FEMALES OF REPRODUCTIVE AGE by Colafella, Katrina Mirabito, Vinh, Antony, Tikellis, Chris, Widdop, Robert, Denton, Kate

“…Objective: Hypertension and cardiovascular disease are age and sex dependent. These differences may, in part, be mediated by the depressor/pressor balance of…”
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