Search Results - "TIJSEN, Anke J"

Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases by Tijsen, Anke J, Pinto, Yigal M, Creemers, Esther E

“…One of the major challenges in cardiovascular disease is the identification of reliable clinical biomarkers that can be routinely measured in plasma. MicroRNAs…”
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Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters by Shinnawi, Rami, Huber, Irit, Maizels, Leonid, Shaheen, Naim, Gepstein, Amira, Arbel, Gil, Tijsen, Anke J., Gepstein, Lior

“…The advent of the human-induced pluripotent stem cell (hiPSC) technology has transformed biomedical research, providing new tools for human disease modeling,…”
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MiR423-5p As a Circulating Biomarker for Heart Failure by Tijsen, Anke J, Creemers, Esther E, Moerland, Perry D, de Windt, Leon J, van der Wal, Allard C, Kok, Wouter E, Pinto, Yigal M

“…RATIONALE:Aberrant expression profiles of circulating microRNAs (miRNAs) have been described in various diseases and provide high sensitivity and specificity…”
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circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs by Aufiero, Simona, Reckman, Yolan J, Tijsen, Anke J, Pinto, Yigal M, Creemers, Esther E

“…Circular RNAs (circRNAs) are a newly appreciated class of non-coding RNA molecules. Numerous tools have been developed for the detection of circRNAs, however…”
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Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing by Tijsen, Anke J., Cócera Ortega, Lucía, Reckman, Yolan J., Zhang, Xiaolei, van der Made, Ingeborg, Aufiero, Simona, Li, Jiuru, Kamps, Selina C., van den Bout, Anouk, Devalla, Harsha D., van Spaendonck-Zwarts, Karin Y., Engelhardt, Stefan, Gepstein, Lior, Ware, James S., Pinto, Yigal M.

“…TTN (Titin), the largest protein in humans, forms the molecular spring that spans half of the sarcomere to provide passive elasticity to the cardiomyocyte…”
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MicroRNAs in Atrial Fibrillation: from Expression Signatures to Functional Implications by van den Berg, Nicoline W. E., Kawasaki, Makiri, Berger, Wouter R., Neefs, Jolien, Meulendijks, Eva, Tijsen, Anke J., de Groot, Joris R.

“…Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with pronounced morbidity and mortality. Its prevalence, expected to further…”
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Patient-Specific Drug Screening Using a Human Induced Pluripotent Stem Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Type 2 by Maizels, Leonid, Huber, Irit, Arbel, Gil, Tijsen, Anke J, Gepstein, Amira, Khoury, Asaad, Gepstein, Lior

“…BACKGROUND—Catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) results from autosomal recessive CASQ2 mutations, causing abnormal Ca-handling…”
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shRNAs Targeting a Common KCNQ1 Variant Could Alleviate Long-QT1 Disease Severity by Inhibiting a Mutant Allele by Cócera-Ortega, Lucía, Wilders, Ronald, Kamps, Selina C, Fabrizi, Benedetta, Huber, Irit, van der Made, Ingeborg, van den Bout, Anouk, de Vries, Dylan K, Gepstein, Lior, Verkerk, Arie O, Pinto, Yigal M, Tijsen, Anke J

“…Long-QT syndrome type 1 (LQT1) is caused by mutations in . Patients heterozygous for such a mutation co-assemble both mutant and wild-type -encoded subunits…”
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Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340 and miRNA624 by Sondermeijer, Brigitte M, Bakker, Annemieke, Halliani, Amalia, de Ronde, Maurice W J, Marquart, Arnoud A, Tijsen, Anke J, Mulders, Ties A, Kok, Maayke G M, Battjes, Suzanne, Maiwald, Steffi, Sivapalaratnam, Suthesh, Trip, Mieke D, Moerland, Perry D, Meijers, Joost C M, Creemers, Esther E, Pinto-Sietsma, Sara-Joan

“…Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies…”
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Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy by Wijnen, Wino J, van der Made, Ingeborg, van den Oever, Stephanie, Hiller, Monika, de Boer, Bouke A, Picavet, Daisy I, Chatzispyrou, Iliana A, Houtkooper, Riekelt H, Tijsen, Anke J, Hagoort, Jaco, van Veen, Henk, Everts, Vincent, Ruijter, Jan M, Pinto, Yigal M, Creemers, Esther E

“…MicroRNAs (miRNAs) regulate many aspects of cellular function and their deregulation has been implicated in heart disease. MiRNA-30c is differentially…”
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Characterization of the mechanism by which a nonsense variant in RYR2 leads to disordered calcium handling by Hopton, Claire, Tijsen, Anke J., Maizels, Leonid, Arbel, Gil, Gepstein, Amira, Bates, Nicola, Brown, Benjamin, Huber, Irit, Kimber, Susan J., Newman, William G., Venetucci, Luigi, Gepstein, Lior

“…Heterozygous missense variants of the cardiac ryanodine receptor gene (RYR2) cause catecholaminergic polymorphic ventricular tachycardia (CPVT). These missense…”
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Circulating MicroRNAs: Novel Biomarkers and Extracellular Communicators in Cardiovascular Disease? by Creemers, Esther E, Tijsen, Anke J, Pinto, Yigal M

“…In the past few years, the crucial role of different micro-RNAs (miRNAs) in the cardiovascular system has been widely recognized. Recently, it was discovered…”
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Toward Biological Pacing by Cellular Delivery of Hcn2/SkM1 by Végh, Anna M D, Verkerk, Arie O, Cócera Ortega, Lucía, Wang, Jianan, Geerts, Dirk, Klerk, Mischa, Lodder, Kirsten, Nobel, Ruby, Tijsen, Anke J, Devalla, Harsha D, Christoffels, Vincent M, Medina-Ramírez, Max, Smits, Anke M, Tan, Hanno L, Wilders, Ronald, Goumans, Marie José T H, Boink, Gerard J J

“…Electronic pacemakers still face major shortcomings that are largely intrinsic to their hardware-based design. Radical improvements can potentially be…”
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Modeling Reentry in the Short QT Syndrome With Human-Induced Pluripotent Stem Cell–Derived Cardiac Cell Sheets by Shinnawi, Rami, Shaheen, Naim, Huber, Irit, Shiti, Assad, Arbel, Gil, Gepstein, Amira, Ballan, Nimer, Setter, Noga, Tijsen, Anke J., Borggrefe, Martin, Gepstein, Lior

“…The short QT syndrome (SQTS) is an inherited arrhythmogenic syndrome characterized by abnormal ion channel function, life-threatening arrhythmias, and sudden…”
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miR-133 and miR-30 Regulate Connective Tissue Growth Factor: Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling by Duisters, Rudy F, Tijsen, Anke J, Schroen, Blanche, Leenders, Joost J, Lentink, Viola, van der Made, Ingeborg, Herias, Veronica, van Leeuwen, Rick E, Schellings, Mark W, Barenbrug, Paul, Maessen, Jos G, Heymans, Stephane, Pinto, Yigal M, Creemers, Esther E

“…The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular…”
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Quaking regulates circular RNA production in cardiomyocytes by Montañés-Agudo, Pablo, van der Made, Ingeborg, Aufiero, Simona, Tijsen, Anke J, Pinto, Yigal M, Creemers, Esther E

“…Circular RNAs (circRNAs) are a class of non-coding RNA molecules that are gaining increasing attention for their roles in various pathophysiological processes…”
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The microRNA-15 family inhibits the TGFβ-pathway in the heart by Tijsen, Anke J, van der Made, Ingeborg, van den Hoogenhof, Maarten M, Wijnen, Wino J, van Deel, Elza D, de Groot, Nina E, Alekseev, Sergey, Fluiter, Kees, Schroen, Blanche, Goumans, Marie-José, van der Velden, Jolanda, Duncker, Dirk J, Pinto, Yigal M, Creemers, Esther E

“…The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis, which contributes to the development of heart failure. Signalling via the…”
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Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms by Smit, Nicoline W, Cócera Ortega, Lucia, Végh, Anna M D, Meijborg, Veronique M F, Smits, Anke M, Klerk, Mischa, Tijsen, Anke J M, Tan, Hanno L, Goumans, Marie-José H T, Boink, Gerard J J, Coronel, Ruben

“…Cardiomyocyte progenitor cells (CMPCs) are a promising cell source for regenerative cell therapy to improve cardiac function after myocardial infarction…”
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Non-cardiomyocyte microRNAs in heart failure by Tijsen, Anke J, Pinto, Yigal M, Creemers, Esther E

“…Multiple structural changes are known to occur in a failing heart. Myocyte hypertrophy, cardiomyocyte apoptosis, interstitial fibrosis, reduced capillary…”
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Long non-coding RNA MEG8 induces endothelial barrier through regulation of microRNA-370 and -494 processing by Kremer, Veerle, Stanicek, Laura, van Ingen, Eva, Bink, Diewertje I, Hilderink, Sarah, Tijsen, Anke J, Wittig, Ilka, Mägdefessel, Lars, Nossent, Anne Yaël, Boon, Reinier A

“…The 14q32 locus is an imprinted region in the human genome which contains multiple non-coding RNAs. We investigated the role of Maternally Expressed Gene 8…”
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