Search Results - "TIGANIS, T"

Insulin action in the brain: Roles in energy and glucose homeostasis by Dodd, G. T., Tiganis, T.

“…A growing body of evidence from research in rodents and humans has identified insulin as an important neuoregulatory peptide in the brain, where it coordinates…”
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Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration by Davies, E M, Kong, A M, Tan, A, Gurung, R, Sriratana, A, Bukczynska, P E, Ooms, L M, McLean, C A, Tiganis, T, Mitchell, C A

“…Glioblastoma is the most common and lethal primary malignant brain tumor in adults. The tumor suppressor gene PTEN is deleted, mutated or hypermethylated in…”
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A novel mitochondrial inhibitor overcomes metabolic reprogramming and enhances the response of NRAS-mutant melanoma cells to MEK inhibition by Rao, A, Smith, L, Parmenter, T, Schreuders, J, Butt, T, Tiganis, T, Culllinane, C, Hogg, P, McArthur, G

“…An abstract of the study by Rao et al hypothesising that the addition of a mitochondrial inhibitor (a novel organic arsenical, PENAO) would enhance the…”
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The Akt kinase signals directly to endothelial nitric oxide synthase by Michell, B.J., Griffiths, J.E., Mitchelhill, K.I., Rodriguez-Crespo, I., Tiganis, T., Bozinovski, S., de Montellano, P.R.Ortiz, Kemp, B.E., Pearson, R.B.

“…Endothelial nitric oxide synthase (eNOS) is an important modulator of angiogenesis and vascular tone [1]. It is stimulated by treatment of endothelial cells in…”
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T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice by Loh, K., Merry, T. L., Galic, S., Wu, B. J., Watt, M. J., Zhang, S., Zhang, Z.-Y., Neel, B. G., Tiganis, T.

“…Aims/hypothesis Insulin activates insulin receptor protein tyrosine kinase and downstream phosphatidylinositol-3-kinase (PI3K)/Akt signalling in muscle to…”
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Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma by Smith, Lorey K., Parmenter, Tiffany, Kleinschmidt, Margarete, Kusnadi, Eric P., Kang, Jian, Martin, Claire A., Lau, Peter, Patel, Riyaben, Lorent, Julie, Papadopoli, David, Trigos, Anna, Ward, Teresa, Rao, Aparna D., Lelliott, Emily J., Sheppard, Karen E., Goode, David, Hicks, Rodney J., Tiganis, Tony, Simpson, Kaylene J., Larsson, Ola, Blythe, Benjamin, Cullinane, Carleen, Wickramasinghe, Vihandha O., Pearson, Richard B., McArthur, Grant A.

“…Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately results in relapse. This…”
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50 - A novel mitochondrial inhibitor overcomes metabolic reprogramming and enhances the response of NRAS-mutant melanoma cells to MEK inhibition by Rao, A., Smith, L., Parmenter, T., Schreuders, J., Butt, T., Tiganis, T., Culllinane, C., Hogg, P., McArthur, G.

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Regulation of Insulin Signaling through Reversible Oxidation of the Protein-tyrosine Phosphatases TC45 and PTP1B by Meng, Tzu-Ching, Buckley, Deirdre A., Galic, Sandra, Tiganis, Tony, Tonks, Nicholas K.

“…Many studies have illustrated that the production of reactive oxygen species (ROS) is important for optimal tyrosine phosphorylation and signaling in response…”
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Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase by Kobe, Bostjan, House, Colin M., Feil, Susanne C., Michell, Belinda J., Tiganis, Tony, Parker, Michael W., Kemp, Bruce E., Cotton, Richard G.H., Jennings, Ian G.

“…Phenylalanine hydroxylase is regulated in a complex manner, including activation by phosphorylation. It is normally found as an equilibrium of dimeric and…”
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Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase by Michell, Belinda J., Chen, Zhi-ping, Tiganis, Tony, Stapleton, David, Katsis, Frosa, Power, David A., Sim, Alistair T., Kemp, Bruce E.

“…Endothelial nitric-oxide synthase (eNOS) is an important regulatory enzyme in the cardiovascular system catalyzing the production of NO from arginine. Multiple…”
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Coordinated Regulation of Insulin Signaling by the Protein Tyrosine Phosphatases PTP1B and TCPTP by Galic, Sandra, Hauser, Christine, Kahn, Barbara B., Haj, Fawaz G., Neel, Benjamin G., Tonks, Nicholas K., Tiganis, Tony

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Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase by Tiganis, Tony, van Vliet, Catherine, Bukczynska, Patricia E, Puryer, Michelle A, Sadek, Christine M, Shields, Benjamin J, Tremblay, Michel L

“…The proinflammatory cytokine tumor necrosis factor (TNF) modulates cellular responses through the mitogen-activated protein kinase (MAPK) and nuclear…”
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DNA Replication Stalling Attenuates Tyrosine Kinase Signaling to Suppress S Phase Progression by Shields, Ben J., Hauser, Christine, Bukczynska, Patricia E., Court, Naomi W., Tiganis, Tony

“…Here we report that T cell protein tyrosine phosphatase (TCPTP)-dependent and -independent pathways attenuate the JAK and Src protein tyrosine kinases (PTKs)…”
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Development of ``Substrate-Trapping" Mutants to Identify Physiological Substrates of Protein Tyrosine Phosphatases by Flint, Andrew J., Tiganis, Tony, Barford, David, Tonks, Nicholas K.

“…The identification of substrates of protein tyrosine phosphatases (PTPs) is an essential step toward a complete understanding of the physiological function of…”
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The Type Iα Inositol Polyphosphate 4-Phosphatase Generates and Terminates Phosphoinositide 3-Kinase Signals on Endosomes and the Plasma Membrane by Ivetac, Ivan, Munday, Adam D., Kisseleva, Marina V., Zhang, Xiang-Ming, Luff, Susan, Tiganis, Tony, Whisstock, James C., Rowe, Tony, Majerus, Phillip W., Mitchell, Christina A.

“…Endosomal trafficking is regulated by the recruitment of effector proteins to phosphatidylinositol 3-phosphate [PtdIns(3)P] on early endosomes. At the plasma…”
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Protein Tyrosine Phosphatases: Dephosphorylating the Epidermal Growth Factor Receptor by Tiganis, Tony

“…Protein tyrosine phosphatases (PTPs) are a large and structurally diverse family of enzymes that are found in eukaryotes, prokaryotes, viruses, and plants…”
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Regulation of Insulin Receptor Signaling by the Protein Tyrosine Phosphatase TCPTP by Galic, Sandra, Klingler-Hoffmann, Manuela, Fodero-Tavoletti, Michelle T., Puryer, Michelle A., Meng, Tzu-Ching, Tonks, Nicholas K., Tiganis, Tony

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism by PRICE, J. T, TIGANIS, T, AGARWAL, A, DJAKIEW, D, THOMPSON, E. W

“…Epidermal growth factor receptor (EGFR) levels predict a poor outcome in human breast cancer and are most commonly associated with proliferative effects of…”
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Inhibition of phosphatidylinositol 3‐kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells by Klingler‐Hoffmann, Manuela, Bukczynska, Patricia, Tiganis, Tony

“…In de novo glioblastoma multiforme, loss of the tumour suppressor protein PTEN can coincide with the expression of a naturally occurring mutant epidermal…”
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Casein kinase II beta-subunit inhibits the activity of the catalytic alpha-subunit in the absence of salt by Tiganis, T, House, C M, Kemp, B E

“…Casein kinase II (CKII) has a subunit structure of alpha 2 beta 2 where alpha is the catalytic subunit. Recombinant Drosophila casein kinase II alpha-subunit…”
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