Search Results - "TIETZ, Pamela S"

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis by Tabibian, James H., O'Hara, Steven P., Trussoni, Christy E., Tietz, Pamela S., Splinter, Patrick L., Mounajjed, Taofic, Hagey, Lee R., LaRusso, Nicholas F.

“…Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be…”
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Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion by Gradilone, Sergio A, Masyuk, Anatoliy I, Splinter, Patrick L, Banales, Jesus M, Huang, Bing Q, Tietz, Pamela S, Masyuk, Tatyana V, LaRusso, Nicholas F

“…Cholangiocytes, epithelial cells lining the biliary tree, have primary cilia extending from their apical membrane into the ductal lumen. Although important in…”
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Up-regulation of microRNA 506 leads to decreased Cl−/HCO3− anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis by Banales, Jesús M., Sáez, Elena, Úriz, Miriam, Sarvide, Sarai, Urribarri, Aura D., Splinter, Patrick, Tietz Bogert, Pamela S., Bujanda, Luis, Prieto, Jesús, Medina, Juan F., LaRusso, Nicholas F.

“…Cl−/HCO 3− anion exchanger 2 (AE2) participates in intracellular pH homeostasis and secretin‐stimulated biliary bicarbonate secretion. AE2/SLC4A2 gene…”
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TLR4 Promotes Cryptosporidium parvum Clearance in a Mouse Model of Biliary Cryptosporidiosis by O'Hara, Steven P, Tietz Bogert, Pamela S, Trussoni, Christy E, Chen, Xianming, LaRusso, Nicholas F

“…Cholangiocytes, the epithelial cells lining intrahepatic bile ducts, express multiple toll-like receptors (TLRs) and, thus, have the capacity to recognize and…”
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Isolation and characterization of cholangiocyte primary cilia by Huang, Bing Q, Masyuk, Tatyana V, Muff, Melissa A, Tietz, Pamela S, Masyuk, Anatoliy I, Larusso, Nicholas F

“…Primary cilia are distinct organelles expressed by many vertebrate cells, including cholangiocytes; however, their functions remain obscure. To begin to…”
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Metabolomic Profiling of Portal Blood and Bile Reveals Metabolic Signatures of Primary Sclerosing Cholangitis by Tietz-Bogert, Pamela S, Kim, Minsuk, Cheung, Angela, Tabibian, James H, Heimbach, Julie K, Rosen, Charles B, Nandakumar, Madhumitha, Lazaridis, Konstantinos N, LaRusso, Nicholas F, Sung, Jaeyun, O'Hara, Steven P

“…Primary sclerosing cholangitis (PSC) is a pathogenically complex, chronic, fibroinflammatory disorder of the bile ducts without known etiology or effective…”
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Agonist-induced Coordinated Trafficking of Functionally Related Transport Proteins for Water and Ions in Cholangiocytes by Tietz, Pamela S., Marinelli, Raul A., Chen, Xian-Ming, Huang, Bing, Cohn, Jonathan, Kole, Jolanta, McNiven, Mark A., Alper, Seth, LaRusso, Nicholas F.

“…We previously proposed that ductal bile formation is regulated by secretin-responsive relocation of aquaporin 1 (AQP1), a water-selective channel protein, from…”
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The zebrafish as a model to study polycystic liver disease by Tietz Bogert, Pamela S, Huang, Bing Q, Gradilone, Sergio A, Masyuk, Tetyana V, Moulder, Gary L, Ekker, Stephen C, Larusso, Nicholas F

“…In the polycystic liver diseases (PLD), genetic defects initiate the formation of cysts in the liver and kidney. In rodent models of PLD (i.e., the PCK rat and…”
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Water Transporting Properties of Hepatocyte Basolateral and Canalicular Plasma Membrane Domains by Marinelli, Raul A., Tietz, Pamela S., Caride, Ariel J., Huang, Bing Q., LaRusso, Nicholas F.

“…Previous work from our laboratory supports an important role for aquaporins (AQPs), a family of water channel proteins, in bile secretion by hepatocytes. To…”
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Phosphatidylinositol 3-Kinase and Frabin Mediate Cryptosporidium parvum Cellular Invasion via Activation of Cdc42 by Chen, Xian-Ming, Splinter, Patrick L, Tietz, Pamela S, Huang, Bing Q, Billadeau, Daniel D, LaRusso, Nicholas F

“…Cryptosporidium parvum invades target epithelia via a mechanism that involves host cell actin reorganization. We previously demonstrated that C. parvum…”
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Cryptosporidium parvum infects human cholangiocytes via sphingolipid‐enriched membrane microdomains by Nelson, Jeremy B., O’Hara, Steven P., Small, Aaron J., Tietz, Pamela S., Choudhury, Amit K., Pagano, Richard E., Chen, Xian‐Ming, LaRusso, Nicholas F.

“…Summary Cryptosporidium parvum attaches to intestinal and biliary epithelial cells via specific molecules on host‐cell surface membranes including…”
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Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes by Marinelli, R A, Tietz, P S, Pham, L D, Rueckert, L, Agre, P, LaRusso, N F

“…Aquaporin-1 (AQP1) water channels are present in the apical and basolateral plasma membrane domains of bile duct epithelial cells, or cholangiocytes, and…”
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Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes by Gong, Ai-Yu, Tietz, Pamela S, Muff, Melissa A, Splinter, Patrick L, Huebert, Robert C, Strowski, Mathias Z, Chen, Xian-Ming, LaRusso, Nicholas F

“…With an in vitro model using enclosed intrahepatic bile duct units (IBDUs) isolated from wild-type and somatostatin receptor (SSTR) subtype 2 knockout mice, we…”
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Cytoskeletal and motor proteins facilitate trafficking of AQP1-containing vesicles in cholangiocytes by Tietz, Pamela S., McNiven, Mark A., Splinter, Patrick L., Huang, Bing Q., LaRusso, Nicholas F.

“…Background information. We have previously showed that: (i) cholangiocytes contain AQP1 (aquaporin 1) water channels sequestered in intracellular vesicles; and…”
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Intrahepatic bile ducts transport water in response to absorbed glucose by Masyuk, Anatoly I, Masyuk, Tatyana V, Tietz, Pamela S, Splinter, Patrick L, LaRusso, Nicholas F

“…The physiological relevance of the absorption of glucose from bile by cholangiocytes remains unclear. The aim of this study was to test the hypothesis that…”
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Multiple TLRs Are Expressed in Human Cholangiocytes and Mediate Host Epithelial Defense Responses to Cryptosporidium parvum via Activation of NF-κB by Chen, Xian-Ming, O’Hara, Steven P., Nelson, Jeremy B., Splinter, Patrick L., Small, Aaron J., Tietz, Pamela S., Limper, Andrew H., LaRusso, Nicholas F.

“…Infection of epithelial cells by Cryptosporidium parvum triggers a variety of host-cell innate and adaptive immune responses including release of…”
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Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography by Tabibian, James H, Macura, Slobodan I, O'Hara, Steven P, Fidler, Jeff L, Glockner, James F, Takahashi, Naoki, Lowe, Val J, Kemp, Bradley J, Mishra, Prasanna K, Tietz, Pamela S, Splinter, Patrick L, Trussoni, Christy E, LaRusso, Nicholas F

“…The cholangiopathies are a diverse group of biliary tract disorders, many of which lack effective treatment. Murine models are an important tool for studying…”
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Isolation and characterization of rat cholangiocyte vesicles enriched in apical or basolateral plasma membrane domains by Tietz, Pamela S, Holman, Ralph T, Miller, Laurence J, LaRusso, Nicholas F

“…Cholangiocytes, the epithelial cells that line intrahepatic bile ducts, are composed of plasma membranes with discrete apical (lumenal) and basolateral…”
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Cryptosporidium parvum activates nuclear factor κb in biliary epithelia preventing epithelial cell apoptosis by CHEN, Xian-Ming, LEVINE, Susan A, SPLINTER, Patrick L, TIETZ, Pamela S, GANONG, Amanda L, JOBIN, Christian, GORES, Gregory J, PAYA, Carlos V, LARUSSO, Nicholas F

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Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes by Gradilone, Sergio A., Garcı́a, Fabiana, Huebert, Robert C., Tietz, Pamela S., Larocca, M.Cecilia, Kierbel, Arlinet, Carreras, Flavia I., LaRusso, Nicholas F., Marinelli, Raúl A.

“…Although glucagon is known to stimulate the cyclic adenosine monophosphate (cAMP)-mediated hepatocyte bile secretion, the precise mechanisms accounting for…”
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