Search Results - "THYFAULT, JOHN P"

Exercise and metabolic health: beyond skeletal muscle by Thyfault, John P., Bergouignan, Audrey

“…Regular exercise is a formidable regulator of insulin sensitivity and overall systemic metabolism through both acute events driven by each exercise bout and…”
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Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms by Booth, Frank W, Roberts, Christian K, Thyfault, John P, Ruegsegger, Gregory N, Toedebusch, Ryan G

“…This review proposes that physical inactivity could be considered a behavior selected by evolution for resting, and also selected to be reinforcing in…”
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Exercise Combats Hepatic Steatosis: Potential Mechanisms and Clinical Implications by Thyfault, John P, Rector, R Scott

“…Hepatic steatosis, the excess storage of intrahepatic lipids, is a rampant clinical problem associated with the obesity epidemic. Hepatic steatosis is linked…”
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Exercise drives metabolic integration between muscle, adipose and liver metabolism and protects against aging-related diseases by Cao, Xin, Thyfault, John P.

“…Over the last few decades, metabolic disease rates have been on the rise, and this is partially due to older individuals (>65 years of age) making up a higher…”
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Exercise: One size does not fit all by Thyfault, John P., Bergouignan, Audrey

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A step-defined sedentary lifestyle index: <5000 steps/day by Tudor-Locke, Catrine, Craig, Cora L, Thyfault, John P, Spence, John C

“…Step counting (using pedometers or accelerometers) is widely accepted by researchers, practitioners, and the general public. Given the mounting evidence of the…”
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Simvastatin Impairs Exercise Training Adaptations by Mikus, Catherine R., PhD, Boyle, Leryn J., MSc, Borengasser, Sarah J., PhD, Oberlin, Douglas J., MSc, Naples, Scott P., MSc, Fletcher, Justin, MSc, Meers, Grace M., BSc, Ruebel, Meghan, MA, Laughlin, M. Harold, PhD, Dellsperger, Kevin C., MD, PhD, Fadel, Paul J., PhD, Thyfault, John P., PhD

“…Objectives This study sought to determine if simvastatin impairs exercise training adaptations. Background Statins are commonly prescribed in combination with…”
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Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism by Tan, Ee Phie, McGreal, Steven R., Graw, Stefan, Tessman, Robert, Koppel, Scott J., Dhakal, Pramod, Zhang, Zhen, Machacek, Miranda, Zachara, Natasha E., Koestler, Devin C., Peterson, Kenneth R., Thyfault, John P., Swerdlow, Russell H., Krishnamurthy, Partha, DiTacchio, Luciano, Apte, Udayan, Slawson, Chad

“…Dysfunctional mitochondria and generation of reactive oxygen species (ROS) promote chronic diseases, which have spurred interest in the molecular mechanisms…”
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Nonalcoholic fatty liver disease and mitochondrial dysfunction by Wei, Yongzhong, Rector, R Scott, Thyfault, John P, Ibdah, Jamal A

“…Nonalcoholic fatty liver disease （NAFLD） includes hepatic steatosis, nonalcoholic steatohepatitis （NASH）, fibrosis, and cirrhosis. NAFLD is the most common…”
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Non-alcoholic fatty liver disease and the metabolic syndrome： An update by Rector, R Scott, Thyfault, John P, Wei, Yongzhong, Ibdah, Jamal A

“…Sedentary lifestyle and poor dietary choices are leading to a weight gain epidemic in westernized countries, subsequently increasing the risk for developing…”
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Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model by Rector, R. Scott, Thyfault, John P, Uptergrove, Grace M, Morris, E. Matthew, Naples, Scott P, Borengasser, Sarah J, Mikus, Catherine R, Laye, Matthew J, Laughlin, M. Harold, Booth, Frank W, Ibdah, Jamal A

“…Background & Aims In this study, we sought to determine the temporal relationship between hepatic mitochondrial dysfunction, hepatic steatosis and insulin…”
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Impact of reduced daily physical activity on conduit artery flow-mediated dilation and circulating endothelial microparticles by Boyle, Leryn J, Credeur, Daniel P, Jenkins, Nathan T, Padilla, Jaume, Leidy, Heather J, Thyfault, John P, Fadel, Paul J

“…Physical inactivity promotes the development of cardiovascular diseases. However, few data exist examining the vascular consequences of short-term reductions…”
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Oral combined contraceptives induce liver mitochondrial reactive oxygen species and whole‐body metabolic adaptations in female mice by Fuller, Kelly N. Z., McCoin, Colin S., Stierwalt, Harrison, Allen, Julie, Gandhi, Shivam, Perry, Christopher G. R., Jambal, Purevsuren, Shankar, Kartik, Thyfault, John P.

“…Compared to age‐matched men, pre‐menopausal women show greater resilience against cardiovascular disease (CVD), hepatic steatosis, diabetes and obesity –…”
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Does physical inactivity cause nonalcoholic fatty liver disease? by SCOTT RECTOR, R, THYFAULT, John P

“…While physical activity represents a key element in the prevention and management of many chronic diseases, we and others believe that physical inactivity is a…”
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A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity by KROGH-MADSEN, Rikke, THYFAULT, John P, BROHOLM, Christa, HARTVIG MORTENSEN, Ole, OLDEN, Rasmus H, MOUNIER, Remi, PLOMGAARD, Peter, VAN HALL, Gerrit, BOOTH, Frank W, PEDERSEN, Bente K

“…US adults take between approximately 2,000 and approximately 12,000 steps per day, a wide range of ambulatory activity that at the low range could increase…”
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Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH by Cunningham, Rory P, Moore, Mary P, Dashek, Ryan J, Meers, Grace M, Takahashi, Takamune, Sheldon, Ryan D, Wheeler, Andrew A, Diaz-Arias, Alberto, Ibdah, Jamal A, Parks, Elizabeth J, Thyfault, John P, Rector, R Scott

“…Regulation of endothelial nitric oxide synthase (eNOS) in hepatocytes may be an important target in nonalcoholic fatty liver disease (NAFLD) development and…”
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eNOS deletion impairs mitochondrial quality control and exacerbates Western diet-induced NASH by Sheldon, Ryan D, Meers, Grace M, Morris, E Matthew, Linden, Melissa A, Cunningham, Rory P, Ibdah, Jamal A, Thyfault, John P, Laughlin, M Harold, Rector, R Scott

“…Dysregulated mitochondrial quality control leads to mitochondrial functional impairments that are central to the development and progression of hepatic…”
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Editorial: Systemic implications of Alzheimer's disease by Cortes, Constanza J, Thyfault, John P, Wilkins, Heather M

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Lowering Physical Activity Impairs Glycemic Control in Healthy Volunteers by MIKUS, Catherine R, OBERLIN, Douglas J, LIBLA, Jessica L, TAYLOR, Angelina M, BOOTH, Frank W, THYFAULT, John P

“…Postprandial glucose (PPG) is an independent predictor of cardiovascular events and death, regardless of diabetes status. Whereas changes in physical activity…”
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Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats by Rector, R Scott, Thyfault, John P, Morris, R Tyler, Laye, Matthew J, Borengasser, Sarah J, Booth, Frank W, Ibdah, Jamal A

“…Exercise training is commonly prescribed for treatment of nonalcoholic fatty liver disease (NAFLD). We sought to determine whether exercise training prevents…”
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