Search Results - "THUPARI, J. N"

Endotoxemia in burn patients: levels of circulating endotoxins are related to burn size by Winchurch, R A, Thupari, J N, Munster, A M

“…With use of a quantitative limulus assay, the levels of circulating endotoxins were examined in a population of burn patients with injuries covering 1% to 88%…”
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Fatty Acid Synthase Inhibition in Human Breast Cancer Cells Leads to Malonyl-CoA-Induced Inhibition of Fatty Acid Oxidation and Cytotoxicity by Thupari, Jagan N., Pinn, Michael L., Kuhajda, Francis P.

“…Inhibition of fatty acid synthase (FAS) induces apoptosis in human breast cancer cells in vitro and in vivo without toxicity to proliferating normal cells. We…”
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C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism by Landree, Leslie E, Hanlon, Andrea L, Strong, David W, Rumbaugh, Gavin, Miller, Ian M, Thupari, Jagan N, Connolly, Erin C, Huganir, Richard L, Richardson, Christine, Witters, Lee A, Kuhajda, Francis P, Ronnett, Gabriele V

“…C75, a synthetic inhibitor of fatty acid synthase (FAS), is hypothesized to alter the metabolism of neurons in the hypothalamus that regulate feeding behavior…”
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Application of a Flexible Synthesis of (5R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase by McFadden, Jill M, Medghalchi, Susan M, Thupari, Jagan N, Pinn, Michael L, Vadlamudi, Aravinda, Miller, Katherine I, Kuhajda, Francis P, Townsend, Craig A

“…Fatty acid synthase (FAS) catalyzes the synthesis of palmitate from the sequential condensation of an acetyl primer with two carbon units added from…”
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The pathogenicity of spontaneously-occurring thyroglobulin-reactive T lymphocytes from BB/WOR rats by Allen, E M, Thupari, J N

“…Autoantigen-reactive T lymphocytes have been implicated in the pathogenesis organ-specific autoimmune disease. Thyroglobulin (Tg) is one of the primary…”
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Thyroglobulin-reactive T lymphocytes in thyroiditis-prone BB/Wor rats by Allen, E M, Thupari, J N

“…Autoimmune lymphocytic thyroiditis (LT) is a common cause of primary hypothyroidism. Autoreactive T lymphocytes are clearly associated with this disorder, but…”
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Depressed natural killer cell function in thermally injured adults: successful in vivo and in vitro immunomodulation and the role of endotoxin by BENDER, B. S, WINCHURCH, R. A, THUPARI, J. N, PROUST, J. J, ADLER, W. H, MUNSTER, A. M

“…Natural killer (NK) cells mediate host defense against infections and are regulated by interleukin 2 (IL-2) and other factors. We studied NK cell function in…”
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Lightning injury: physics, pathophysiology and clinical features by Moran, K T, Thupari, J N, Munster, A M

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Reversal of postburn immunosuppression with low-dose polymyxin B by Munster, A M, Winchurch, R A, Thupari, J N, Ernst, C B

“…In a randomized study of 28 patients with thermal injury, polymyxin B was administered intravenously in small doses to attempt to block the immunosuppressive…”
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Effect of immunoglobulin G therapy on serum antibody titers to cytomegalovirus in burn patients by Moran, K T, Thupari, J N, O'Reilly, T J, Munster, A M

“…We attempted to determine the incidence and significance of cytomegalovirus infection and the effect of immunoglobulin G infusions on specific cytomegalovirus…”
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C75 Increases Peripheral Energy Utilization and Fatty Acid Oxidation in Diet-Induced Obesity by Thupari, Jagan N., Landree, Leslie E., Ronnett, Gabriele V., Kuhajda, Francis P.

“…C75, a known inhibitor of fatty acid synthase is postulated to cause significant weight loss through decreased hypothalamic neuropeptide Y (NPY) production…”
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Autoantibody formation in burn patients after inhibition of suppressor T cell activity with polymyxin B by Moran, K T, Anholt, G T, O'Reilly, T J, Thupari, J N, Munster, A M

“…After thermal injury, treatment with polymyxin B blocks suppressor T cell activity by uncoupling endotoxin-mediated T cell activation, but the effect on…”
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Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass by Thupari, Jagan N, Kim, Eun-Kyoung, Moran, Timothy H, Ronnett, Gabriele V, Kuhajda, Francis P

“…Obesity and its attendant disorders, such as type 2 diabetes, are global health problems. We previously reported that C75, an inhibitor of fatty acid synthase…”
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C75 Alters Central and Peripheral Gene Expression to Reduce Food Intake and Increase Energy Expenditure by Tu, Yajun, Thupari, Jagan N, Kim, Eun-Kyoung, Pinn, Michael L, Moran, Timothy H, Ronnett, Gabriele V, Kuhajda, Francis P

“…C75, a synthetic inhibitor of fatty acid synthase (FAS), causes anorexia and profound weight loss in lean and genetically obese mice. C75 also acts as a…”
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Thyroglobulin-reactive T lymphocytes in thryoiditis-prone BB/Wor rats by ALLEN, E. M, THUPARI, J. N

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Electric- and lightning-induced cardiac arrest reversed by cardiopulmonary resuscitation by Moran, K T, Thupari, J N, Munster, A M

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Electric- and lightning-induced cardiac arrest reversed by cardiopulmonary resuscitation by Moran, K T, Thupari, J N, Munster, A M

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