Search Results - "THRELKELD, Penny G"

In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic acid (LY379268) by Fell, Matthew J, Perry, Kenneth W, Falcone, Julie F, Johnson, Bryan G, Barth, Vanessa N, Rash, Karen S, Lucaites, Virginia L, Threlkeld, Penny G, Monn, James A, McKinzie, David L, Marek, Gerard J, Svensson, Kjell A, Nelson, David L

“…Some recently published in vitro studies with two metabotropic glutamate 2/3 receptor (mGluR(2/3)) agonists [(-)-2-oxa-4-aminobicyclo[3.1.0]…”
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Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat: A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder by Bymaster, Frank P, Katner, Jason S, Nelson, David L, Hemrick-Luecke, Susan K, Threlkeld, Penny G, Heiligenstein, John H, Morin, S.Michelle, Gehlert, Donald R, Perry, Kenneth W

“…The selective norepinephrine (NE) transporter inhibitor atomoxetine (formerly called tomoxetine or LY139603) has been shown to alleviate symptoms in Attention…”
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Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in vitro and in vivo, Human Serotonin Receptor Subtypes, and Other Neuronal Receptors by Bymaster, Frank P., Dreshfield-Ahmad, Laura J., Threlkeld, Penny G., Shaw, Janice L., Thompson, Linda, Nelson, David L., Hemrick-Luecke, Susan K., Wong, David T.

“…The blockade of serotonin (5-HT) and norepinephrine (NE) transporters in vitro and in vivo by the dual 5-HT/NE reuptake inhibitors duloxetine and venlafaxine…”
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R-fluoxetine Increases Extracellular DA, NE, As Well As 5-HT in Rat Prefrontal Cortex and Hypothalamus: An in vivo Microdialysis and Receptor Binding Study by Koch, Susanne, Perry, Kenneth W, Nelson, David L, Conway, Richard G, Threlkeld, Penny G, Bymaster, Frank P

“…The selective serotonin reuptake inhibitor fluoxetine consists of equal amounts of R and S stereoisomers. In this study, we investigated the pharmacologic…”
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Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in rats by Koch, Susanne, Hemrick-Luecke, Susan K., Thompson, Linda K., Evans, David C., Threlkeld, Penny G., Nelson, David L., Perry, Kenneth W., Bymaster, Frank P.

“…Compounds that block both serotonin (5-HT) and norepinephrine (NE) transporters have been proposed to have improved antidepressant efficacy. We compared the…”
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Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography:  Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of 11C-Labeled 2-(Phenylthio)araalkylamines by Wilson, Alan A, Ginovart, Nathalie, Schmidt, Mark, Meyer, Jeffery H, Threlkeld, Penny G, Houle, Sylvain

“…A series of four 2-(phenylthio)araalkylamines have been radiolabeled with 11C and evaluated as potential radiotracers for imaging the serotonin transporter…”
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Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4 by ROCCO, Vincent P, SPINAZZE, Patrick G, TAKEUCHI, Kumiko, KOHN, Todd J, HONIGSCHMIDT, Nicholas A, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T

“…A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was…”
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Advances toward new antidepressants beyond SSRIs : 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5 by TAKEUCHI, Kumiko, KOHN, Todd J, LODGE, David, MARTIN, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, HEMRICK-LUECKE, Susan K, THOMPSON, Linda K, EVANS, David C, RASMUSSEN, Kurt, KOGER, Deanna

“…A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered…”
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Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1 by TAKEUCHI, Kumiko, KOHN, Todd J, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, KOCH, Daniel J, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J, SHAW, Janice

“…A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered…”
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Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3 by TAKEUCHI, Kumiko, KOHN, Todd J, SHAW, Janice, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, ATKINSON, Steven T, HERTEL, Larry W, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J

“…A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered…”
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Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2 by TAKEUCHI, Kumiko, KOHN, Todd J, AHMAD, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, KOCH, Daniel J, ATKINSON, Steven T, HERTEL, Larry W, NELSON, David L, WAINSCOTT, D. Bradley

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Expedited discovery of second generation NK-1 antagonists: identification of a nonbasic aryloxy substituent by Fritz, James E., Hipskind, Philip A., Lobb, Karen L., Nixon, James A., Threlkeld, Penny G., Gitter, Bruce D., McMillian, Carl L., Kaldor, Stephen W.

“…Solution-phase, parallel-synthesis techniques were used to optimize a series of nonbasic NK-1 antagonists, resulting in the identification of ( R)- 26, an…”
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3-Aryl-1,2-diacetamidopropane Derivatives as Novel and Potent NK-1 Receptor Antagonists by Hipskind, Philip A, Howbert, J. Jeffry, Bruns, Robert F, Cho, Steven S. Y, Crowell, Thomas A, Foreman, Mark M, Gehlert, Donald R, Iyengar, Smriti, Johnson, Kirk W, Krushinski, Joseph H, Li, Dominic L, Lobb, Karen L, Mason, Norman R, Muehl, Brian S, Nixon, James A, Phebus, Lee A, Regoli, Domenico, Simmons, Rosa M, Threlkeld, Penny G, Waters, Diane C, Gitter, Bruce D

“…Early structure−activity studies on racemic tryptophan ester and amide NK-1 antagonists 5−7 led to the discovery that the potency of the series could be…”
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Fluoxetine and two other serotonin uptake inhibitors without affinity for neuronal receptors by Wong, D T, Bymaster, F P, Reid, L R, Threlkeld, P G

“…Fluoxetine and nine other antidepressant drugs which interact with brain receptors for neurotransmitters were studied in vitro using radioligand-binding…”
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Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT 1A receptor antagonism/SSRI activities. Part 5 by Takeuchi, Kumiko, Kohn, Todd J., Honigschmidt, Nicholas A., Rocco, Vincent P., Spinazze, Patrick G., Hemrick-Luecke, Susan K., Thompson, Linda K., Evans, David C., Rasmussen, Kurt, Koger, Deanna, Lodge, David, Martin, Laura J., Shaw, Janice, Threlkeld, Penny G., Wong, David T.

“…A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT 1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1…”
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Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT sub(1A) receptor antagonism/SSRI activities by Takeuchi, Kumiko, Kohn, Todd J, Honigschmidt, Nicholas A, Rocco, Vincent P, Spinazze, Patrick G, Hemrick-Luecke, Susan K, Thompson, Linda K, Evans, David C, Rasmussen, Kurt, Koger, Deanna, Lodge, David, Martin, Laura J, Shaw, Janice, Threlkeld, Penny G, Wong, David T

“…A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5- HT sub(1A) receptor antagonism and serotonin reuptake inhibition was discovered…”
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Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography: Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of 11C-Labeled 2-(Phenylthio)araalkylamines by WILSON, Alan A., GINOVART, Nathalie, SCHMIDT, Mark, MEYER, Jeffery H., THRELKELD, Penny G., HOULE, Sylvain

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Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography: Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of 11 C-Labeled 2-(Phenylthio)araalkylamines by Wilson, Alan A., Ginovart, Nathalie, Schmidt, Mark, Meyer, Jeffery H., Threlkeld, Penny G., Houle, Sylvain

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Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography:  Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of 11 C-Labeled 2-(Phenylthio)araalkylamines by Wilson, Alan A., Ginovart, Nathalie, Schmidt, Mark, Meyer, Jeffery H., Threlkeld, Penny G., Houle, Sylvain

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Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT 1A receptor antagonism/SSRI activities. Part 4 by Rocco, Vincent P., Spinazze, Patrick G., Kohn, Todd J., Honigschmidt, Nicholas A., Nelson, David L., Bradley Wainscott, D., Ahmad, Laura J., Shaw, Janice, Threlkeld, Penny G., Wong, David T., Takeuchi, Kumiko

“…A series of 1-(1 H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT 1A receptor antagonism and serotonin reuptake inhibition was…”
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