Search Results - "THORSHEIM, Helen R"

Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer by Taskar, Kunal S., Rudraraju, Vinay, Mittapalli, Rajendar K., Samala, Ramakrishna, Thorsheim, Helen R., Lockman, Julie, Gril, Brunilde, Hua, Emily, Palmieri, Diane, Polli, Joseph W., Castellino, Stephen, Rubin, Stephen D., Lockman, Paul R., Steeg, Patricia S., Smith, Quentin R.

“…ABSTRACT Purpose Lapatinib, a small molecule EGFR/HER2 inhibitor, partially inhibits the outgrowth of HER2+ brain metastases in preclinical models and in a…”
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Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer by LOCKMAN, Paul R, MITTAPALLI, Rajendar K, SUYUN HUANG, PALMIERI, Diane, STEEG, Patricia S, SMITH, Quentin R, TASKAR, Kunal S, RUDRARAJU, Vinay, GRIL, Brunilde, BOHN, Kaci A, ADKINS, Chris E, ROBERTS, Amanda, THORSHEIM, Helen R, GAASCH, Julie A

“…Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic…”
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Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study by Morikawa, Aki, Peereboom, David M, Thorsheim, Helen R, Samala, Ramakrishna, Balyan, Rajiv, Murphy, Conleth G, Lockman, Paul R, Simmons, Ahkeem, Weil, Robert J, Tabar, Viviane, Steeg, Patricia S, Smith, Quentin R, Seidman, Andrew D

“…Breast cancer brain metastases (BCBM) are challenging complications that respond poorly to systemic therapy. The role of the blood-tumor barrier in limiting…”
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Vinorelbine Delivery and Efficacy in the MDA-MB-231BR Preclinical Model of Brain Metastases of Breast Cancer by Samala, Ramakrishna, Thorsheim, Helen R., Goda, Satyanarayana, Taskar, Kunal, Gril, Brunilde, Steeg, Patricia S., Smith, Quentin R.

“…Purpose To evaluate vinorelbine drug exposure and activity in brain metastases of the human MDA-MB-231BR breast cancer model using integrated imaging and…”
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Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer by Thomas, Fancy C, Taskar, Kunal, Rudraraju, Vinay, Goda, Satyanarayana, Thorsheim, Helen R, Gaasch, Julie A, Mittapalli, Rajendar K, Palmieri, Diane, Steeg, Patricia S, Lockman, Paul R, Smith, Quentin R

“…Purpose We evaluated the uptake of angiopep-2 paclitaxel conjugate, ANG1005, into brain and brain metastases of breast cancer in rodents. Most anticancer drugs…”
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Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis by Wu, Alex Man Lai, Gossa, Selamawit, Samala, Ramakrishna, Chung, Monika A, Gril, Brunilde, Yang, Howard H, Thorsheim, Helen R, Tran, Andy D, Wei, Debbie, Taner, Esra, Isanogle, Kristine, Yang, Yuan, Dolan, Emma L, Robinson, Christina, Difilippantonio, Simone, Lee, Maxwell P, Khan, Imran, Smith, Quentin R, McGavern, Dorian B, Wakefield, Lalage M, Steeg, Patricia S

“…Breast cancer diagnosed in young patients is often aggressive. Because primary breast tumors from young and older patients have similar mutational patterns, we…”
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Liquid chromatography–tandem mass spectrometry for the determination of methylprednisolone in rat plasma and liver after intravenous administration of its liver-targeted dextran prodrug by Zhang, Shuang-Qing, Thorsheim, Helen R., Penugonda, Suman, Pillai, Venkateswaran C., Smith, Quentin R., Mehvar, Reza

“…A specific and sensitive liquid chromatography (LC)–tandem mass spectrometric method for quantitative determination of methylprednisolone (MP) in rat plasma…”
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Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks by PALMIERI, Diane, LOCKMAN, Paul R, TASKAR, Kunal S, RUDRARAJU, Vinay, MITTAPALLI, Rajendar K, GAASCH, Julie A, BOHN, Kaci A, THORSHEIM, Helen R, LIEWEHR, David J, DAVIS, Sean, REILLY, John F, WALKER, Robert, THOMAS, Fancy C, BRONDER, Julie L, FEIGENBAUM, Lionel, STEINBERG, Seth M, CAMPHAUSEN, Kevin, MELTZER, Paul S, RICHON, Victoria M, SMITH, Quentin R, STEEG, Patricia S, HUA, Emily, HERRING, Jeanne, HARGRAVE, Elizabeth, JOHNSON, Matthew, FLORES, Natasha, YONGZHEN QIAN, VEGA-VALLE, Eleazar

“…Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few…”
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Regulatory Aspects of the Introduction of New Macronutrient Substitutes by RULIS, ALAN M., PELLICORE, LINDA S., THORSHEIM, HELEN R.

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