Search Results - "THORNER, Michael O"

Endoscopic Transsphenoidal Surgery for Acromegaly: Remission Using Modern Criteria, Complications, and Predictors of Outcome by Jane, John A, Starke, Robert M, Elzoghby, Mohamed A, Reames, Davis L, Payne, Spencer C, Thorner, Michael O, Marshall, John C, Laws, Edward R, Vance, Mary Lee

“…Context: Despite the growing application of endoscopic transsphenoidal surgery (ETSS), outcomes for GH adenomas are not clearly defined. Objective: We reviewed…”
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Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food by Goldstone, Anthony P, Prechtl, Christina G, Scholtz, Samantha, Miras, Alexander D, Chhina, Navpreet, Durighel, Giuliana, Deliran, Seyedeh S, Beckmann, Christian, Ghatei, Mohammad A, Ashby, Damien R, Waldman, Adam D, Gaylinn, Bruce D, Thorner, Michael O, Frost, Gary S, Bloom, Stephen R, Bell, Jimmy D

“…Background: Ghrelin, which is a stomach-derived hormone, increases with fasting and energy restriction and may influence eating behaviors through brain hedonic…”
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Late Recurrences of Cushing’s Disease after Initial Successful Transsphenoidal Surgery by Patil, Chirag G., Prevedello, Daniel M., Lad, Shivanand P., Vance, Mary Lee, Thorner, Michael O., Katznelson, Laurence, Laws, Edward R.

“…Context: Few studies have systematically analyzed the long-term recurrence rates of Cushing’s disease after initial successful transsphenoidal surgery…”
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Acyl and Total Ghrelin Are Suppressed Strongly by Ingested Proteins, Weakly by Lipids, and Biphasically by Carbohydrates by Foster-Schubert, Karen E., Overduin, Joost, Prudom, Catherine E., Liu, Jianhua, Callahan, Holly S., Gaylinn, Bruce D., Thorner, Michael O., Cummings, David E.

“…Context: Ghrelin is an orexigenic hormone that can increase body weight. Its circulating levels increase before meals and are suppressed after food ingestion…”
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The Effects of Vertical Sleeve Gastrectomy in Rodents Are Ghrelin Independent by Chambers, Adam P, Kirchner, Henriette, Wilson–Perez, Hilary E, Willency, Jill A, Hale, John E, Gaylinn, Bruce D, Thorner, Michael O, Pfluger, Paul T, Gutierrez, Jesus A, Tschöp, Matthias H, Sandoval, Darleen A, Seeley, Randy J

“…Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and…”
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Correlation between GH and IGF-1 during treatment for acromegaly by Oldfield, Edward H, Jane, Jr, John A, Thorner, Michael O, Pledger, Carrie L, Sheehan, Jason P, Vance, Mary Lee

“…OBJECTIVE The relationship between growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in patients with acromegaly as serial levels drop over time…”
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Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models by Berryman, Darlene E, Christiansen, Jens Sandahl, Johannsson, Gudmundur, Thorner, Michael O, Kopchick, John J

“…Abstract Animal models are fundamentally important in our quest to understand the genetic, epigenetic, and environmental factors that contribute to human…”
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Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients: a randomized blinded study by Campbell, Garland A, Patrie, James T, Gaylinn, Bruce D, Thorner, Michael O, Bolton, Warren K

“…Protein-energy wasting (PEW) in end-stage renal disease (ESRD) patients is associated with increased morbidity and mortality, but options for treatment are…”
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A Case for Conservative Management: Characterizing the Natural History of Radiographically Diagnosed Rathke Cleft Cysts by Culver, Silas A, Grober, Yuval, Ornan, David A, Patrie, James T, Oldfield, Edward H, Jane, John A, Thorner, Michael O

“…Context: Rathke cleft cysts (RCCs) are benign embryonic remnants of the Rathke's pouch found in 13% to 33% of the general population. When symptomatic, they…”
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Age-Dependent Decline in Acyl-Ghrelin Concentrations and Reduced Association of Acyl-Ghrelin and Growth Hormone in Healthy Older Adults by Nass, Ralf, Farhy, Leon S, Liu, Jianhua, Pezzoli, Suzan S, Johnson, Michael L, Gaylinn, Bruce D, Thorner, Michael O

“…Background: Acyl-ghrelin is thought to have both orexigenic effects and to stimulate GH release. A possible cause of the anorexia of aging is an age-dependent…”
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The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects by Tong, Jenny, Dave, Nimita, Mugundu, Ganesh M, Davis, Harold W, Gaylinn, Bruce D, Thorner, Michael O, Tschöp, Matthias H, D'Alessio, David, Desai, Pankaj B

“…BackgroundGhrelin stimulates GH secretion and regulates energy and glucose metabolism. The two circulating isoforms, acyl (AG) and des-acyl (DAG) ghrelin, have…”
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Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice Is Independent of Ghrelin by Rogers, Nicole H, Walsh, Heidi, Alvarez-Garcia, Oscar, Park, Seongjoon, Gaylinn, Bruce, Thorner, Michael O, Smith, Roy G

“…Aging is associated with attenuated ghrelin signaling. During aging, chronic caloric restriction (CR) produces health benefits accompanied by enhanced ghrelin…”
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The ghrelin axis in disease: Potential therapeutic indications by Nass, Ralf, Gaylinn, Bruce D., Thorner, Michael O.

“…Ghrelin, the natural ligand for the growth hormone (GH)-secretagogue receptor (GHS-R), is produced predominantly in the stomach. It is present in the…”
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Comparison of Competitive Radioimmunoassays and Two-Site Sandwich Assays for the Measurement and Interpretation of Plasma Ghrelin Levels by Prudom, Catherine, Liu, Jianhua, Patrie, James, Gaylinn, Bruce D., Foster-Schubert, Karen E., Cummings, David E., Thorner, Michael O., Geysen, H. Mario

“…Context: Ghrelin, an endogenous ligand for the GH secretagogue receptor, is an orexigenic peptide hormone produced primarily by the stomach. Recent studies…”
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Caloric Restriction in mTORC1 Control of Intestinal Homeostasis by Harris, Thurl E., Thorner, Michael O.

“…Reducing caloric intake, while maintaining adequate nutrition, promotes longevity in diverse organisms, possibly by preserving stem and progenitor cell…”
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The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction by Yi, Chun-Xia, Heppner, Kristy M, Kirchner, Henriette, Tong, Jenny, Bielohuby, Maximillian, Gaylinn, Bruce D, Müller, Timo D, Bartley, Erin, Davis, Harold W, Zhao, Yongmei, Joseph, Anupama, Kruthaupt, Traci, Ottaway, Nickki, Kabra, Dhiraj, Habegger, Kirk M, Benoit, Stephen C, Bidlingmaier, Martin, Thorner, Michael O, Perez-Tilve, Diego, Tschöp, Matthias H, Pfluger, Paul T

“…Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative…”
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Evidence for Acyl-Ghrelin Modulation of Growth Hormone Release in the Fed State by Nass, Ralf, Farhy, Leon S., Liu, Jianhua, Prudom, Catherine E., Johnson, Michael L., Veldhuis, Paula, Pezzoli, Suzan S., Oliveri, Mary Clancy, Gaylinn, Bruce D., Geysen, H. Mario, Thorner, Michael O.

“…Context: The timing and frequency of GH secretory episodes is regulated by GHRH and somatostatin. This study provides evidence for amplification of these GH…”
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Ghrelin and growth hormone: Story in reverse by Nass, Ralf M, Gaylinn, Bruce D, Rogol, Alan D, Thorner, Michael O

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Association of Plasma Des-acyl Ghrelin Levels with CKD by Gupta, Rohit K, Kuppusamy, Tamil, Patrie, James T, Gaylinn, Bruce, Liu, Jianhua, Thorner, Michael O, Bolton, Warren K

“…There are no effective therapies for malnutrition in CKD/ESRD patients. This study hypothesized that ghrelin, an endogenous orexigenic hormone, would correlate…”
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Primary hypophysitis: a single-center experience in 16 cases by LEUNG, Gilberto K. K, LOPES, Maria-Beatriz S, THORNER, Michael O, VANCE, Mary Lee, LAWS, Edward R

“…The authors review their experience in the treatment of 16 patients with primary hypophysitis. A retrospective study was undertaken to review cases of primary…”
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