Search Results - "THOMSON, Jodi M"

Analysis of Antibiotic Resistance Genes in Multidrug-Resistant Acinetobacter sp. Isolates from Military and Civilian Patients Treated at the Walter Reed Army Medical Center by HUJER, Kristine M, HUJER, Andrea M, THOMSON, Jodi M, RATHER, Philip N, CRAFT, David W, FISHBAIN, Joel T, EWELL, Allesa J, JACOBS, Michael R, PATERSON, David L, BONOMO, Robert A, HULTEN, Edward A, BAJAKSOUZIAN, Saralee, ADAMS, Jennifer M, DONSKEY, Curtis J, ECKER, David J, MASSIRE, Christian, ESHOO, Mark W, SAMPATH, Rangarajan

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Exploring the Inhibition of CTX-M-9 by β-Lactamase Inhibitors and Carbapenems by BETHEL, Christopher R, TARACILA, Magdalena, BONOMO, Robert A, SHYR, Teresa, THOMSON, Jodi M, DISTLER, Anne M, HUJER, Kristine M, HUJER, Andrea M, ENDIMIANI, Andrea, PAPP-WALLACE, Krisztina, BONNET, Richard

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Rapid Determination of Quinolone Resistance in Acinetobacter spp by Hujer, Kristine M, Hujer, Andrea M, Endimiani, Andrea, Thomson, Jodi M, Adams, Mark D, Goglin, Karrie, Rather, Philip N, Pennella, Thuy-Trang D, Massire, Christian, Eshoo, Mark W, Sampath, Rangarajan, Blyn, Lawrence B, Ecker, David J, Bonomo, Robert A

“…In the treatment of serious bacterial infections, the rapid institution of appropriate antimicrobial chemotherapy may be lifesaving. Choosing the correct…”
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Identification of a New Allelic Variant of the Acinetobacter baumannii Cephalosporinase, ADC-7 β-Lactamase: Defining a Unique Family of Class C Enzymes by HUJER, Kristine M, HAMZA, Nashaat S, TENOVER, Fred C, BONOMO, Robert A, HUJER, Andrea M, PEREZ, Federico, HELFAND, Marion S, BETHEL, Christopher R, THOMSON, Jodi M, ANDERSON, Vernon E, BARLOW, Miriam, RICE, Louis B

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Development of a Multiplex PCR-Ligase Detection Reaction Assay for Diagnosis of Infection by the Four Parasite Species Causing Malaria in Humans by MCNAMARA, David T, THOMSON, Jodi M, KASEHAGEN, Laurin J, ZIMMERMAN, Peter A

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Inhibition of OXA-1 β-Lactamase by Penems by BETHEL, Christopher R, DISTLER, Anne M, ANDERSON, Vernon E, LEONARD, David A, HUJER, Kristine M, ABE, Takao, VENKATESAN, Aranapakam M, MANSOUR, Tarek S, BONOMO, Robert A, RUSZCZYCKY, Mark W, CAREY, Marianne P, CAREY, Paul R, HUJER, Andrea M, TARACILA, Magda, HELFAND, Marion S, THOMSON, Jodi M, KALP, Matthew

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Use of Novel Boronic Acid Transition State Inhibitors To Probe Substrate Affinity in SHV-Type Extended-Spectrum β-Lactamases by THOMSON, Jodi M, PRATI, Fabio, BETHEL, Christopher R, BONOMO, Robert A

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Role of Asp104 in the SHV β-Lactamase by BETHEL, Christopher R, HUJER, Andrea M, HUJER, Kristine M, THOMSON, Jodi M, RUSZCZYCKY, Mark W, ANDERSON, Vernon E, PUSZTAI-CAREY, Marianne, TARACILA, Magdalena, HELFAND, Marion S, BONOMO, Robert A

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The threat of antibiotic resistance in Gram-negative pathogenic bacteria: β-lactams in peril by Thomson, Jodi M, Bonomo, Robert A

“…β-Lactam antibiotics are the cornerstone of our antibiotic armamentarium. By inhibiting bacterial cell wall synthesis, they are highly effective against…”
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Crystal Structure of KPC-2:  Insights into Carbapenemase Activity in Class A β-Lactamases by Ke, Wei, Bethel, Christopher R, Thomson, Jodi M, Bonomo, Robert A, van den Akker, Focco

“…β-Lactamases inactivate β-lactam antibiotics and are a major cause of antibiotic resistance. The recent outbreaks of Klebsiella pneumoniae carbapenem resistant…”
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Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1 by Nukaga, Michiyosi, Bethel, Christopher R, Thomson, Jodi M, Hujer, Andrea M, Distler, Anne, Anderson, Vernon E, Knox, James R, Bonomo, Robert A

“…Carbapenem antibiotics are often the “last resort” in the treatment of infections caused by bacteria resistant to penicillins and cephalosporins. To understand…”
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Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance by Thomson, Jodi M, Distler, Anne M, Prati, Fabio, Bonomo, Robert A

“…Inhibitor-resistant class A beta-lactamases are an emerging threat to the use of beta-lactam/beta-lactamase inhibitor combinations (e.g…”
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Computational Redesign of the SHV-1 β-Lactamase/β-Lactamase Inhibitor Protein Interface by Reynolds, Kimberly A., Hanes, Melinda S., Thomson, Jodi M., Antczak, Andrew J., Berger, James M., Bonomo, Robert A., Kirsch, Jack F., Handel, Tracy M.

“…β-lactamases are enzymes that catalyze the hydrolysis of β-lactam antibiotics. β-lactamase/β-lactamase inhibitor protein (BLIP) complexes are emerging as a…”
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Structural and Computational Characterization of the SHV-1 β-Lactamase-β-Lactamase Inhibitor Protein Interface by Reynolds, Kimberly A., Thomson, Jodi M., Corbett, Kevin D., Bethel, Christopher R., Berger, James M., Kirsch, Jack F., Bonomo, Robert A., Handel, Tracy M.

“…β-Lactamase inhibitor protein (BLIP) binds a variety of class A β-lactamases with affinities ranging from micromolar to picomolar. Whereas the TEM-1 and SHV-1…”
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Overcoming Resistance to β-Lactamase Inhibitors:  Comparing Sulbactam to Novel Inhibitors against Clavulanate Resistant SHV Enzymes with Substitutions at Ambler Position 244 by Thomson, Jodi M, Distler, Anne M, Bonomo, Robert A

“…Amino acid changes at Ambler position R244 in class A TEM and SHV β-lactamases confer resistance to ampicillin/clavulanate, a β-lactam/β-lactamase inhibitor…”
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Diagnosis of malaria by magnetic deposition microscopy by Zimmerman, Peter A, Thomson, Jodi M, Fujioka, Hisashi, Collins, William E, Zborowski, Maciej

“…Although malaria contributes to a significant public health burden, malaria diagnosis relies heavily on either non-specific clinical symptoms or blood smear…”
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Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition by Sulton, Deley, Pagan-Rodriguez, Doritza, Zhou, Xiang, Liu, Yiding, Hujer, Andrea M, Bethel, Christopher R, Helfand, Marion S, Thomson, Jodi M, Anderson, Vernon E, Buynak, John D, Ng, Lily M, Bonomo, Robert A

“…Clavulanic acid is a potent mechanism-based inhibitor of TEM-1 and SHV-1beta-lactamases, enzymes that confer resistance to beta-lactams in many gram-negative…”
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Antimicrobials : The threat of antibiotic resistance in Gram-negative pathogenic bacteria : β-lactams in peril by THOMSON, Jodi M, BONOMO, Robert A

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Use of Novel Boronic Acid Transition State Inhibitors To Probe Substrate Affinity in SHV-Type Extended-Spectrum {szligbeta}-Lactamases by Thomson, Jodi M, Prati, Fabio, Bethel, Christopher R, Bonomo, Robert A

“…Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K…”
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Probing Active Site Chemistry in SHV β-Lactamase Variants at Ambler Position 244 by Thomson, Jodi M., Distler, Anne M., Prati, Fabio, Bonomo, Robert A.

“…Inhibitor-resistant class A β-lactamases are an emerging threat to the use of β-lactam/β-lactamase inhibitor combinations (e.g. amoxicillin/clavulanate) in the…”
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