Search Results - "THOMPSON, SALLY A."

Induction of glutamate-cysteine ligase (γ-glutamylcysteine synthetase) in the brains of adult female mice subchronically exposed to methylmercury by Thompson, Sally A, White, Collin C, Krejsa, Cecile M, Diaz, Dolores, Woods, James S, Eaton, David L, Kavanagh, Terrance J

“…Methylmercury (MeHg) is widely known for its potent neurotoxic properties. One proposed mechanism of action of MeHg relates to its high affinity for sulfhydryl…”
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Glutathione redox potential in response to differentiation and enzyme inducers by Kirlin, Ward G, Cai, Jiyang, Thompson, Sally A, Diaz, Dolores, Kavanagh, Terrance J, Jones, Dean P

“…The reduced glutathione (GSH)/oxidized glutathione (GSSG) redox state is thought to function in signaling of detoxification gene expression, but also appears…”
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3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues:  High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1 by Carling, Robert W, Moore, Kevin W, Street, Leslie J, Wild, Deborah, Isted, Catherine, Leeson, Paul D, Thomas, Steven, O'Connor, Desmond, McKernan, Ruth M, Quirk, Katherine, Cook, Susan M, Atack, John R, Wafford, Keith A, Thompson, Sally A, Dawson, Gerard R, Ferris, Pushpinder, Castro, José L

“…Studies with our screening lead 5 and the literature compound 6 led to the identification of 6-benzyloxy-3-(4-methoxy)phenyl-1,2,4-triazolo[3,4-a]phthalazine 8…”
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Molecular and Functional Diversity of the Expanding GABA-A Receptor Gene Family by WHITING, PAUL J., BONNERT, TIMOTHY P., MCKERNAN, RUTH M., FARRAR, SOPHIE, BOURDELLES, BEATRICE LE, HEAVENS, ROBERT P., SMITH, DAVID W., HEWSON, LOUISE, RIGBY, MICHAEL R., SIRINATHSINGHJI, DALIP J. S., THOMPSON, SALLY A., WAFFORD, KEITH A.

“…Fast inhibitory neurotransmission in the mammalian CNS is mediated primarily by the neurotransmitter γ‐aminobutyric acid (GABA), which, upon binding to its…”
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The pharmacology of spontaneously open α1β3ε GABAA receptor-ionophores by MAKSAY, Gabor, THOMPSON, Sally A, WAFFORD, Keith A

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Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABAAα5 Benzodiazepine Binding Site by Street, Leslie J, Sternfeld, Francine, Jelley, Richard A, Reeve, Austin J, Carling, Robert W, Moore, Kevin W, McKernan, Ruth M, Sohal, Bindi, Cook, Susan, Pike, Andrew, Dawson, Gerard R, Bromidge, Frances A, Wafford, Keith A, Seabrook, Guy R, Thompson, Sally A, Marshall, George, Pillai, Goplan V, Castro, José L, Atack, John R, MacLeod, Angus M

“…The identification of a novel series of 7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines as GABAAα5 inverse agonists, which have both…”
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Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABAA receptors by EBERT, Bjarke, MORTENSEN, Martin, THOMPSON, Sally A, KEHLER, Jan, WAFFORD, Keith A, KROGSGAARD-LARSEN, Povl

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Allosteric modulators affect the efficacy of partial agonists for recombinant GABA(A) receptors by Maksay, G, Thompson, S A, Wafford, K A

“…Different alpha subunits of human gamma-aminobutyric acid type A (GABA(A)) receptors were transiently expressed together with beta(3) and gamma(2) subunits in…”
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Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development by THOMPSON, Sally A, WHITE, Collin C, KREJSA, Cecile M, EATON, David L, KAVANAGH, Terrance J

“…The antioxidant tripeptide glutathione has been proposed to be important in defense against oxidative stress and heavy metal toxicity. We evaluated alterations…”
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Induction of the Cell Cycle Regulatory Gene p21 (Waf1, Cip1) Following Methylmercury Exposure in Vitro and in Vivo by Ou, Ying C., Thompson, Sally A., Ponce, Rafael A., Schroeder, Jesara, Kavanagh, Terrance J., Faustman, Elaine M.

“…Methylmercury (MeHg) is recognized as a significant environmental hazard, particularly to the development of the nervous system. To study the molecular…”
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Allosteric modulators affect the efficacy of partial agonists for recombinant GABAA receptors by Maksay, Gábor, Thompson, Sally A, Wafford, Keith A

“…Different α subunits of human γ‐aminobutyric acid type A (GABAA) receptors were transiently expressed together with β3 and γ2 subunits in Xenopus oocytes to…”
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Evidence for a Significant Role of α3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines by Dias, Rebecca, Sheppard, Wayne F. A., Fradley, Rosa L., Garrett, Elizabeth M., Stanley, Joanna L., Tye, Spencer J., Goodacre, Simon, Lincoln, Rachael J., Cook, Susan M., Conley, Rachel, Hallett, David, Humphries, Alexander C., Thompson, Sally A., Wafford, Keith A., Street, Leslie J., Castro, J. Luis, Whiting, Paul J., Rosahl, Thomas W., Atack, John R., McKernan, Ruth M., Dawson, Gerard R., Reynolds, David S.

“…The GABA A receptor subtypes responsible for the anxiolytic effects of nonselective benzodiazepines (BZs) such as chlordiazepoxide (CDP) and diazepam remain…”
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3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1 by Carling, Robert W, Moore, Kevin W, Street, Leslie J, Wild, Deborah, Isted, Catherine, Leeson, Paul D, Thomas, Steven, O'Connor, Desmond, McKernan, Ruth M, Quirk, Katherine, Cook, Susan M, Atack, John R, Wafford, Keith A, Thompson, Sally A, Dawson, Gerard R, Ferris, Pushpinder, Castro, José L

“…Studies with our screening lead 5 and the literature compound 6 led to the identification of 6-benzyloxy-3-(4-methoxy)phenyl-1,2,4-triazolo[3,4-a]phthalazine 8…”
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Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABAA Receptor Subunit Conferring Atypical Functional Properties by Whiting, Paul J, McAllister, George, Vassilatis, Demetrios, Bonnert, Timothy P, Heavens, Robert P, Smith, David W, Hewson, Louise, O'Donnell, Ruth, Rigby, Michael R, Sirinathsinghji, Dalip J. S, Marshall, George, Thompson, Sally A, Wafford, Keith A

“…We report the isolation and characterization of a cDNA encoding a novel member of the GABA receptor gene family, epsilon. This polypeptide is 506 amino acids…”
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Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABA A Receptor Subunit Conferring Atypical Functional Properties by Whiting, Paul J., McAllister, George, Vassilatis, Demetrios, Bonnert, Timothy P., Heavens, Robert P., Smith, David W., Hewson, Louise, O’Donnell, Ruth, Rigby, Michael R., Sirinathsinghji, Dalip J. S., Marshall, George, Thompson, Sally A., Wafford, Keith A.

“…We report the isolation and characterization of a cDNA encoding a novel member of the GABA receptor gene family, ε. This polypeptide is 506 amino acids in…”
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Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors by Ebert, B, Thompson, S A, Saounatsou, K, McKernan, R, Krogsgaard-Larsen, P, Wafford, K A

“…Using human gamma-aminobutyric acid type A (GABAA) receptor subunit combinations, expressed in cell lines and Xenopus laevis oocytes, the pharmacology of a…”
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The pharmacology of spontaneously open alpha 1 beta 3 epsilon GABA A receptor-ionophores by Maksay, Gábor, Thompson, Sally A, Wafford, Keith A

“…Human alpha(1)beta(3) epsilon GABA(A) receptors were expressed in Xenopus oocytes and examined using the conventional two-electrode voltage-clamp technique and…”
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The pharmacology of spontaneously open α 1β 3ε GABA A receptor–ionophores by Maksay, Gábor, Thompson, Sally A., Wafford, Keith A.

“…Human α 1β 3ε GABA A receptors were expressed in Xenopus oocytes and examined using the conventional two-electrode voltage-clamp technique and compared to α 1β…”
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Mechanism of α-subunit selectivity of benzodiazepine pharmacology at γ-aminobutyric acid type A receptors by Wingrove, Peter B, Safo, Patrick, Wheat, Lola, Thompson, Sally A, Wafford, Keith A, Whiting, Paul J

“…Benzodiazepine pharmacology at the GABA A receptor is dependent on the α and γ subunit isoforms present. Ligands with higher affinity for certain…”
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Evidence for a Significant Role of α3-Containing GABA A Receptors in Mediating the Anxiolytic Effects of Benzodiazepines by Dias, Rebecca, Sheppard, Wayne F. A., Fradley, Rosa L., Garrett, Elizabeth M., Stanley, Joanna L., Tye, Spencer J., Goodacre, Simon, Lincoln, Rachael J., Cook, Susan M., Conley, Rachel, Hallett, David, Humphries, Alexander C., Thompson, Sally A., Wafford, Keith A., Street, Leslie J., Castro, J. Luis, Whiting, Paul J., Rosahl, Thomas W., Atack, John R., McKernan, Ruth M., Dawson, Gerard R., Reynolds, David S.

“…The GABA A receptor subtypes responsible for the anxiolytic effects of nonselective benzodiazepines (BZs) such as chlordiazepoxide (CDP) and diazepam remain…”
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