Search Results - "THOMPSON, Patrick A"

Nanoshell-mediated photothermal therapy improves survival in a murine glioma model by Day, Emily S., Thompson, Patrick A., Zhang, Linna, Lewinski, Nastassja A., Ahmed, Nabil, Drezek, Rebekah A., Blaney, Susan M., West, Jennifer L.

“…We are developing a novel treatment for high-grade gliomas using near infrared-absorbing silica–gold nanoshells that are thermally activated upon exposure to a…”
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A Phase 1 Study of the Proteasome Inhibitor Bortezomib in Pediatric Patients with Refractory Leukemia: a Children's Oncology Group Study by HORTON, Terzah M, PATI, Debananda, BLANEY, Susan M, PLON, Sharon E, THOMPSON, Patrick A, BOMGAARS, Lisa R, ADAMSON, Peter C, INGLE, Ashish M, WRIGHT, John, BROCKMAN, Adam H, PATON, Martin

“…Purpose: A phase 1 study to determine the maximum-tolerated dose, dose-limiting toxicity, pharmacokinetics, and biological effects of bortezomib in children…”
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The Population Pharmacokinetics of High-Dose Methotrexate in Infants with Acute Lymphoblastic Leukemia Highlight the Need for Bedside Individualized Dose Adjustment: A Report from the Children’s Oncology Group by Beechinor, Ryan J., Thompson, Patrick A., Hwang, Michael F., Vargo, Ryan C., Bomgaars, Lisa R., Gerhart, Jacqueline G., Dreyer, ZoAnn E., Gonzalez, Daniel

“…Background Infants with acute lymphoblastic leukemia (ALL) treated with high-dose methotrexate may have reduced methotrexate clearance (CL) due to renal…”
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Phase I Pharmacokinetic and Pharmacodynamic Study of Temozolomide in Pediatric Patients With Refractory or Recurrent Leukemia: A Children's Oncology Group Study by HORTON, Terzah M, THOMPSON, Patrick A, BLANEY, Susan M, BERG, Stacey L, ADAMSON, Peter C, INGLE, Ashish M, DOLAN, M. Eileen, DELANEY, Shannon M, HEDGE, Madhuri, WEISS, Heidi L, WU, Meng-Fen

“…To determine the tolerability, pharmacokinetics, and mechanisms of temozolomide resistance in children with relapsed or refractory leukemia. Cohorts of three…”
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Doxorubicin in combination with cisplatin, 5‐flourouracil, and vincristine is feasible and effective in unresectable hepatoblastoma: A Children's Oncology Group study by Katzenstein, Howard M., Malogolowkin, Marcio H., Krailo, Mark D., Piao, Jin, Towbin, Alexander J., McCarville, M. Beth, Tiao, Gregory M., Dunn, Stephen P., Langham, Max R., McGahren, Eugene D., Finegold, Milton J., Ranganathan, Sarangarajan, Weldon, Christopher B., Thompson, Patrick A., Trobaugh‐Lotrario, Angela D., O’Neill, Allison F., Furman, Wayne L., Chung, Nadia, Randazzo, Jessica, Rodriguez‐Galindo, Carlos, Meyers, Rebecka L.

“…Background The Children's Oncology Group (COG) adopted cisplatin, 5‐flourouracil, and vincristine (C5V) as standard therapy after the INT‐0098 legacy study…”
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First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children’s Oncology Group Phase 1/Pilot Consortium by Balis, Frank M., Thompson, Patrick A., Mosse, Yael P., Blaney, Susan M., Minard, Charles G., Weigel, Brenda J., Fox, Elizabeth

“…Purpose Characterize the pharmacokinetics of oral crizotinib in children with cancer. Methods Sixty-four children with solid tumors or anaplastic large-cell…”
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A Phase I Trial of Imetelstat in Children with Refractory or Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Study (ADVL1112) by THOMPSON, Patrick A, DRISSI, Rachid, BLANEY, Susan M, MUSCAL, Jodi A, PANDITHARATNA, Eshini, FOULADI, Maryam, INGLE, Ashish M, AHERN, Charlotte H, REID, Joel M, TONG LIN, WEIGEL, Brenda J

“…Imetelstat is a covalently-lipidated 13-mer thiophosphoramidate oligonucleotide that acts as a potent specific inhibitor of telomerase. It binds with high…”
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Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer by Bissig-Choisat, Beatrice, Kettlun-Leyton, Claudia, Legras, Xavier D, Zorman, Barry, Barzi, Mercedes, Chen, Leon L, Amin, Mansi D, Huang, Yung-Hsin, Pautler, Robia G, Hampton, Oliver A, Prakash, Masand M, Yang, Diane, Borowiak, Malgorzata, Muzny, Donna, Doddapaneni, Harsha Vardhan, Hu, Jianhong, Shi, Yan, Gaber, M. Waleed, Hicks, M. John, Thompson, Patrick A, Lu, Yiling, Mills, Gordon B, Finegold, Milton, Goss, John A, Parsons, D. Williams, Vasudevan, Sanjeev A, Sumazin, Pavel, López-Terrada, Dolores, Bissig, Karl-Dimiter

“…Graphical abstract…”
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Vincristine/irinotecan/temsirolimus upfront window treatment of high‐risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 Study Committee by Thompson, Patrick A., Malogolowkin, Marcio H., Furman, Wayne L., Piao, Jin, Krailo, Mark D., Chung, Nadia, Brock, Lindsay, Towbin, Alexander J., McCarville, Elizabeth B., Finegold, Milton J., Ranganathan, Sarangarajan, Dunn, Stephen P., Langham, Max R., McGahren, Eugene D., Tiao, Gregory M., Weldon, Christopher B., O'Neill, Allison F., Rodriguez‐Galindo, Carlos, Meyers, Rebecka L., Katzenstein, Howard M.

“…Background Survival for children with metastatic hepatoblastoma (HB) remains suboptimal. We report the response rate and outcome of two courses of…”
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Relapsed hepatoblastoma confined to the lung is effectively treated with pulmonary metastasectomy by Shi, Yan, Geller, James I, Ma, Irene T, Chavan, Rishikesh S, Masand, Prakash M, Towbin, Alexander J, Chintagumpala, Murali, Nuchtern, Jed G, Tiao, Greg M, Thompson, Patrick A, Vasudevan, Sanjeev A

“…Abstract Background In children diagnosed with hepatoblastoma (HB), the lungs are the most common site of metastasis at both initial presentation and relapse…”
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Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines by Bernardi, Ronald J., Lowery, Amanda R., Thompson, Patrick A., Blaney, Susan M., West, Jennifer L.

“…We are developing a novel approach to specifically target malignant brain tumor cells for photothermal ablation using antibody-tagged, near infrared-absorbing…”
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A prospective study of a simple algorithm to individually dose high-dose methotrexate for children with leukemia at risk for methotrexate toxicities by Foster, Jennifer H., Thompson, Patrick A., Bernhardt, M. Brooke, Margolin, Judith F., Hilsenbeck, Susan G., Jo, Eunji, Marquez-Do, Deborah A., Scheurer, Michael E., Schafer, Eric S.

“…Purpose High-dose methotrexate (HDMTX) is critical to the successful treatment of pediatric acute lymphoblastic leukemia (ALL) but can cause significant…”
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A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: A Children's Oncology Group phase I consortium study (ADVL0916) by Muscal, Jodi A., Thompson, Patrick A., Horton, Terzah M., Ingle, Ashish M., Ahern, Charlotte H., McGovern, Renee M., Reid, Joel M., Ames, Matthew M., Espinoza-Delgado, Igor, Weigel, Brenda J., Blaney, Susan M.

“…Background A pediatric Phase I trial was performed to determine the maximum‐tolerated dose, dose‐limiting toxicities (DLTs), and pharmacokinetics (PK) of…”
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Renal and hepatic tumors in the neonatal period by Thompson, Patrick A, Chintagumpala, Murali

“…Summary Renal and hepatic tumors in neonates are extremely rare. Nevertheless it is important for clinicians to be familiar with them. Both renal and hepatic…”
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Targeted Therapy in Bone and Soft Tissue Sarcoma in Children and Adolescents by Thompson, Patrick A., Chintagumpala, Murali

“…Pediatric soft-tissue and bone sarcomas are a heterogeneous group of tumors of mesenchymal origin which affect approximately 1,500 children in the United…”
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Relapse surveillance in AFP-positive hepatoblastoma: re-evaluating the role of imaging by Rojas, Yesenia, Guillerman, R. Paul, Zhang, Wei, Vasudevan, Sanjeev A., Nuchtern, Jed G., Thompson, Patrick A.

“…Background Children with hepatoblastoma routinely undergo repetitive surveillance imaging, with CT scans for several years after therapy, increasing the risk…”
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Focal nodular hyperplasia in children: An institutional experience with review of the literature by Ma, Irene T, Rojas, Yesenia, Masand, Prakash M, Castro, Eumenia C, Himes, Ryan W, Kim, Eugene S, Goss, John A, Nuchtern, Jed G, Finegold, Milton J, Thompson, Patrick A, Vasudevan, Sanjeev A

“…Abstract Background Focal nodular hyperplasia (FNH) is uncommonly diagnosed in pediatric patients and may be difficult to distinguish from a malignancy. We…”
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Vascular-targeted photothermal therapy of an orthotopic murine glioma model by Day, Emily S, Zhang, Linna, Thompson, Patrick A, Zawaski, Janice A, Kaffes, Caterina C, Gaber, M Waleed, Blaney, Susan M, West, Jennifer L

“…To develop nanoshells for vascular-targeted photothermal therapy of glioma. The ability of nanoshells conjugated to VEGF and/or poly(ethylene glycol) (PEG) to…”
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Reply to: No correlation between estimated and actual glomerular filtration rates in pediatric oncology patients by Bernhardt, Melanie B., Thompson, Patrick A.

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Using a Bedside Algorithm to Individually Dose High-dose Methotrexate for Patients at Risk for Toxicity by Foster, Jennifer H, Bernhardt, Melanie B, Thompson, Patrick A, Smith, E OʼBrian, Schafer, Eric S

“…We developed a bedside algorithm for individually adjusting the high-dose methotrexate (HDMTX) dose (5 g/m) given to patients with acute lymphoblastic leukemia…”
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