Search Results - "THOMPSON, James R"

The Regulation of Parathyroid Hormone Secretion and Synthesis by KUMAR, Rajiv, THOMPSON, James R

“…Secondary hyperparathyroidism classically appears during the course of chronic renal failure and sometimes after renal transplantation. Understanding the…”
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Rapid Assembly of a Multimeric Membrane Protein Pore by Thompson, James R., Cronin, Bríd, Bayley, Hagan, Wallace, Mark I.

“…We have observed the assembly of the staphylococcal pore-forming toxin α-hemolysin using single-molecule fluorescence imaging. Surprisingly, assembly from the…”
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Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair by Botuyan, Maria Victoria, Lee, Joseph, Ward, Irene M., Kim, Ja-Eun, Thompson, James R., Chen, Junjie, Mer, Georges

“…Histone lysine methylation has been linked to the recruitment of mammalian DNA repair factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand…”
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Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor by Mer, Georges, Lee, Joseph, Thompson, James R, Botuyan, Maria Victoria

“…The lysine demethylase JMJD2A has the unique property of binding trimethylated peptides from two different histone sequences (H3K4me3 and H4K20me3) through its…”
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Constructing droplet interface bilayers from the contact of aqueous droplets in oil by Leptihn, Sebastian, Castell, Oliver K, Cronin, Brid, Lee, En-Hsin, Gross, Linda C M, Marshall, David P, Thompson, James R, Holden, Matthew, Wallace, Mark I

“…We describe a protocol for forming an artificial lipid bilayer by contacting nanoliter aqueous droplets in an oil solution in the presence of phospholipids. A…”
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An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering by Cui, Gaofeng, Botuyan, Maria Victoria, Drané, Pascal, Hu, Qi, Bragantini, Benoît, Thompson, James R., Schuller, David J., Detappe, Alexandre, Perfetti, Michael T., James, Lindsey I., Frye, Stephen V., Chowdhury, Dipanjan, Mer, Georges

“…The recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4 dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break…”
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Lipid Directed Intrinsic Membrane Protein Segregation by Hansen, Jesper S, Thompson, James R, Hélix-Nielsen, Claus, Malmstadt, Noah

“…We demonstrate a new approach for direct reconstitution of membrane proteins during giant vesicle formation. We show that it is straightforward to create a…”
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Simultaneous Measurement of Ionic Current and Fluorescence from Single Protein Pores by Heron, Andrew J, Thompson, James R, Cronin, Bríd, Bayley, Hagan, Wallace, Mark I

“…The ability to simultaneously monitor both the ionic current and fluorescence from membrane channels and pores has the potential to link structural changes…”
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Modelling and Molecular Dynamics Predict the Structure and Interactions of the Glycine Receptor Intracellular Domain by Thompson, James R E, Beaudoin, Christopher A, Lummis, Sarah C R

“…Glycine receptors (GlyRs) are glycine-gated inhibitory pentameric ligand-gated ion channels composed of α or α + β subunits. A number of structures of these…”
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Kinetic Control in Protein Folding for Light Chain Amyloidosis and the Differential Effects of Somatic Mutations by Blancas-Mejía, Luis.M., Tischer, Alexander, Thompson, James R., Tai, Jonathan, Wang, Lin, Auton, Matthew, Ramirez-Alvarado, Marina

“…Light chain amyloidosis is a devastating disease where immunoglobulin light chains form amyloid fibrils, resulting in organ dysfunction and death. Previous…”
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In Vitro Reconstitution of Eukaryotic Ion Channels Using Droplet Interface Bilayers by Leptihn, Sebastian, Thompson, James R, Ellory, J. Clive, Tucker, Stephen J, Wallace, Mark I

“…The ability to routinely study eukaryotic ion channels in a synthetic lipid environment would have a major impact on our understanding of how different lipids…”
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Hard superconductivity of a soft metal in the quantum regime by Thompson, James R, Weitering, Hanno H, Özer, Mustafa M

“…Superconductivity is inevitably suppressed in reduced dimensionality. Questions of how thin superconducting wires or films can be before they lose their…”
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Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1 by Singh, Namit, Basnet, Harihar, Wiltshire, Timothy D, Mohammad, Duaa H, Thompson, James R, Héroux, Annie, Botuyan, Maria Victoria, Yaffe, Michael B, Couch, Fergus J, Rosenfeld, Michael G, Mer, Georges

“…Tyr142, the C-terminal amino acid of histone variant H2A.X is phosphorylated by WSTF (Williams-Beuren syndrome transcription factor), a component of the WICH…”
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Tuning the Quantum Stability and Superconductivity of Ultrathin Metal Alloys by Özer, Mustafa M, Jia, Yu, Zhang, Zhenyu, Thompson, James R, Weitering, Hanno H

“…Quantum confinement of itinerant electrons in atomically smooth ultrathin lead films produces strong oscillations in the thickness-dependent film energy. By…”
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Direct Detection of Membrane Channels from Gels Using Water-in-Oil Droplet Bilayers by Heron, Andrew J, Thompson, James R, Mason, Amy E, Wallace, Mark I

“…We form planar lipid bilayers between an aqueous droplet and a hydrogel support immersed in a lipid−oil solution. By scanning the bilayer over the surface of…”
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Altered Dimer Interface Decreases Stability in an Amyloidogenic Protein by Baden, Elizabeth M., Owen, Barbara A.L., Peterson, Francis C., Volkman, Brian F., Ramirez-Alvarado, Marina, Thompson, James R.

“…Amyloidoses are devastating and currently incurable diseases in which the process of amyloid formation causes fatal cellular and organ damage. The molecular…”
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Enhanced Stability and Fluidity in Droplet on Hydrogel Bilayers for Measuring Membrane Protein Diffusion by Thompson, James R, Heron, Andrew J, Santoso, Yusdi, Wallace, Mark I

“…We form artificial lipid bilayers suitable for single-molecule fluorescence microscopy by contacting an aqueous droplet with a hydrogel support immersed in a…”
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Cost-effectiveness of Telaprevir combination therapy for chronic hepatitis C by Brogan, Anita J, Talbird, Sandra E, Thompson, James R, Miller, Jeffrey D, Rubin, Jaime, Deniz, Baris

“…To explore the expected long-term health and economic outcomes of telaprevir (TVR) plus peginterferon alfa-2a and ribavirin (PR), a regimen that demonstrated…”
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The Structure of the Human Centrin 2-Xeroderma Pigmentosum Group C Protein Complex by Thompson, James R., Ryan, Zachary C., Salisbury, Jeffrey L., Kumar, Rajiv

“…Human centrin-2 plays a key role in centrosome function and stimulates nucleotide excision repair by binding to the xeroderma pigmentosum group C protein. To…”
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Structural Insights into the Role of Mutations in Amyloidogenesis by Baden, Elizabeth M., Randles, Edward G., Aboagye, Awo K., Thompson, James R., Ramirez-Alvarado, Marina

“…Mechanisms of amyloidogenesis are not well understood, including potential structural contributions of mutations in the process. Our previous research…”
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