Search Results - "THOMPSON, J. A"

Digital Soil Mapping and Modeling at Continental Scales: Finding Solutions for Global Issues by Grunwald, S, Thompson, J.A, Boettinger, J.L

“…Profound shifts have occurred during the last three centuries in which human actions have become the main driver to global environmental change. In this new…”
Get full text

Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis by Fisniku, L. K., Brex, P. A., Altmann, D. R., Miszkiel, K. A., Benton, C. E., Lanyon, R., Thompson, A. J., Miller, D. H.

“…Clinically isolated syndromes (CIS), such as optic neuritis, brainstem or spinal cord syndromes are frequently the first clinical presentations of multiple…”
Get full text

Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation by Jones, Joanne L., Thompson, Sara A. J., Loh, Priscilla, Davies, Jessica L., Tuohy, Orla C., Curry, Allison J., Azzopardi, Laura, Hill-Cawthorne, Grant, Fahey, Michael T., Compston, Alastair, Coles, Alasdair J.

“…The association between lymphopenia and autoimmunity is recognized, but the underlying mechanisms are poorly understood and have not been studied…”
Get full text

Neural correlates of motor recovery after stroke: a longitudinal fMRI study by Ward, N. S., Brown, M. M., Thompson, A. J., Frackowiak, R. S. J.

“…Recovery of motor function after stroke may occur over weeks or months and is often attributed to cerebral reorganization. We have investigated the…”
Get full text

Neural correlates of outcome after stroke: a cross‐sectional fMRI study by Ward, N. S., Brown, M. M., Thompson, A. J., Frackowiak, R. S. J.

“…Recovery of motor function after stroke may occur over weeks or months and is often attributed to neuronal reorganization. Functional imaging studies…”
Get full text

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis by Montalban, X., Gold, R., Thompson, A. J., Otero‐Romero, S., Amato, M. P., Chandraratna, D., Clanet, M., Comi, G., Derfuss, T., Fazekas, F., Hartung, H. P., Havrdova, E., Hemmer, B., Kappos, L., Liblau, R., Lubetzki, C., Marcus, E., Miller, D. H., Olsson, T., Pilling, S., Selmaj, K., Siva, A., Sorensen, P. S., Sormani, M. P., Thalheim, C., Wiendl, H., Zipp, F.

“…Background and purpose Multiple sclerosis (MS) is a complex disease with new drugs becoming available in the past years. There is therefore a need for a…”
Get full text

Adoptive T Cell Therapy Using Antigen-Specific CD8+T Cell Clones for the Treatment of Patients with Metastatic Melanoma: In vivo Persistence, Migration, and Antitumor Effect of Transferred T Cells by Yee, C., Thompson, J. A., Byrd, D., Riddell, S. R., Roche, P., Celis, E., Greenberg, P. D.

“…Adoptive T cell therapy, involving the ex vivo selection and expansion of antigen-specific T cell clones, provides a means of augmenting antigen-specific…”
Get full text

Comparison of small-sample standard-error corrections for generalised estimating equations in stepped wedge cluster randomised trials with a binary outcome: A simulation study by Thompson, JA, Hemming, K, Forbes, A, Fielding, K, Hayes, R

“…Generalised estimating equations with the sandwich standard-error estimator provide a promising method of analysis for stepped wedge cluster randomised trials…”
Get full text

Measuring the impact of MS on walking ability: The 12-Item MS Walking Scale (MSWS-12) by HOBART, J. C, RIAZI, A, LAMPING, D. L, FITZPATRICK, R, THOMPSON, A. J

“…To develop a patient-based measure of walking ability in MS. Twelve items describing the impact of MS on walking (12-Item MS Walking Scale [MSWS-12]) were…”
Get full text

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging by Johansen-Berg, H, Behrens, T E J, Woolrich, M W, Smith, S M, Wheeler-Kingshott, C A M, Boulby, P A, Barker, G J, Sillery, E L, Sheehan, K, Ciccarelli, O, Thompson, A J, Brady, J M, Matthews, P M

“…Evidence concerning anatomical connectivities in the human brain is sparse and based largely on limited post-mortem observations. Diffusion tensor imaging has…”
Get full text

B-Cell Reconstitution and BAFF After Alemtuzumab (Campath-1H) Treatment of Multiple Sclerosis by Thompson, Sara A. J., Jones, Joanne L., Cox, Amanda L., Compston, D. Alastair S., Coles, Alasdair J.

“…Introduction Treatment with alemtuzumab is highly effective in relapsing–remitting multiple sclerosis; however, 30% of patients develop autoimmunity…”
Get full text

Robust analysis of stepped wedge trials using cluster‐level summaries within periods by Thompson, J.A., Davey, C., Fielding, K., Hargreaves, J.R., Hayes, R.J.

“…In stepped‐wedge trials (SWTs), the intervention is rolled out in a random order over more than 1 time‐period. SWTs are often analysed using mixed‐effects…”
Get full text

Direct Measurement of Single-Molecule Ligand–Receptor Interactions by Lam, K.-T, Taylor, E. L, Thompson, A. J, Ruepp, M.-D, Lochner, M, Martinez, Michael J, Brozik, J. A

“…Measuring the kinetics that govern ligand–receptor interactions is fundamental to our understanding of pharmacology. For ligand-gated ion channels, binding of…”
Get full text

The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington's disease: a pilot study by Thompson, J. A., Cruickshank, T. M., Penailillo, L. E., Lee, J. W., Newton, R. U., Barker, R. A., Ziman, M. R.

“…Background and purpose Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation,…”
Get full text

New insights into the effects of ethylene on ABA catabolism, sweetening and dormancy in stored potato tubers by Tosetti, R., Waters, A., Chope, G.A., Cools, K., Alamar, M.C., McWilliam, S., Thompson, A.J., Terry, L.A.

“…•Continuous ethylene activates ACO transcription and respiration in potatoes.•1-MCP completely inhibits the respiratory rise induced by continuous ethylene…”
Get full text

What are the implications of variation in root hair length on tolerance to phosphorus deficiency in combination with water stress in barley (Hordeum vulgare)? by Brown, L.K., George, T.S., Thompson, J.A., Wright, G., Lyon, J., Dupuy, L., Hubbard, S.F., White, P.J.

“…• Background and Aims Phosphorus commonly limits crop yield and is frequently applied as fertilizer; however, supplies of quality rock phosphate for fertilizer…”
Get full text

Everolimus in metastatic renal cell carcinoma: Subgroup analysis of patients with 1 or 2 previous vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapies enrolled in the phase III RECORD-1 study by Calvo, E, Escudier, B, Motzer, R.J, Oudard, S, Hutson, T.E, Porta, C, Bracarda, S, Grünwald, V, Thompson, J.A, Ravaud, A, Kim, D, Panneerselvam, A, Anak, O, Figlin, R.A

“…Abstract Introduction In the phase III RECORD-1 trial (ClinicalTrials.gov: NCT00410124 ), patients with metastatic renal cell carcinoma (mRCC) who progressed…”
Get full text

Interferon beta-1b in secondary progressive MS: A combined analysis of the two trials by KAPPOS, L, WEINSHENKER, B, POZZILLI, C, THOMPSON, A. J, DAHLKE, F, BECKMANN, K, POLMAN, C, MCFARLAND, H

“…A European (EU) and a North American (NA) placebo-controlled study with interferon beta-1b (IFNB-1b) in secondary progressive multiple sclerosis (SPMS) showed…”
Get full text

A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanoma by O'Day, S, Pavlick, A, Loquai, C, Lawson, D, Gutzmer, R, Richards, J, Schadendorf, D, Thompson, J A, Gonzalez, R, Trefzer, U, Mohr, P, Ottensmeier, C, Chao, D, Zhong, B, de Boer, C J, Uhlar, C, Marshall, D, Gore, M E, Lang, Z, Hait, W, Ho, P

“…Background: α v integrins are involved in angiogenesis and melanoma tumourigenesis. Intetumumab (CNTO 95) is a fully human anti- α v -integrin monoclonal…”
Get full text

Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up by Zajicek, J P, Sanders, H P, Wright, D E, Vickery, P J, Ingram, W M, Reilly, S M, Nunn, A J, Teare, L J, Fox, P J, Thompson, A J

“…Objective: To test the effectiveness and long term safety of cannabinoids in multiple sclerosis (MS), in a follow up to the main Cannabinoids in Multiple…”
Get full text