Search Results - "THOMASSEN, D. G"

Molecular Detection of Venous Thrombosis in Mouse Models Using SPECT/CT by Dickhout, Annemiek, Van de Vijver, Pieter, Bitsch, Nicole, van Hoof, Stefan J., Thomassen, Stella L. G. D., Massberg, Steffen, Timmerman, Peter, Verhaegen, Frank, Koenen, Rory R., Dijkgraaf, Ingrid, Hackeng, Tilman M.

“…The efficacy of thrombolysis is inversely correlated with thrombus age. During early thrombogenesis, activated factor XIII (FXIIIa) cross-links α2-AP to fibrin…”
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Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography by Tchaikovski, Svetlana N, van Vliet, Huib A A M, Thomassen, M C L G D, Bertina, Rogier M, Rosendaal, Frits R, Sandset, Per-Morten, Helmerhorst, Frans M, Tans, Guido, Rosing, Jan

“…In a study population consisting of healthy men (n = 8), women not using oral contraceptives (OC) (n = 28) and women using different kinds of OC (n = 187) we…”
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Severe thrombophilia in a factor V‐deficient patient homozygous for the Ala2086Asp mutation (FV Besançon) by Castoldi, Elisabetta, Hézard, Nathalie, Mourey, Guillaume, Wichapong, Kanin, Poggi, Marjorie, Ibrahim‐Kosta, Manal, Thomassen, M. Christella L. G. D., Fournel, Alexandra, Hayward, Catherine P. M., Alessi, Marie‐Christine, Hackeng, Tilman M., Rosing, Jan, Morange, Pierre‐Emmanuel

“…Background Coagulation factor V (FV), present in plasma and platelets, has both pro‐ and anticoagulant functions. Objective We investigated an FV‐deficient…”
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Activated protein C resistance determined with a thrombin generation‐based test predicts for venous thrombosis in men and women by Tans, Guido, Van Hylckama Vlieg, Astrid, Thomassen, M. Christella L. G. D., Curvers, Joyce, Bertina, Rogier M., Rosing, Jan, Rosendaal, Frits R.

“…Activated protein C (APC) resistance, determined with a thrombin‐generation‐based APC resistance test, may explain risk differences of venous thrombosis in…”
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Role of protein S and tissue factor pathway inhibitor in the development of activated protein C resistance early in pregnancy in women with a history of preeclampsia by Tchaikovski, S N, Thomassen, M C L G D, Costa, S-D, Peeters, L L H, Rosing, J

“…Pregnancy increases the risk of venous thromboembolism. Particularly in early pregnancy, the thrombosis risk can be attributed to the changes in coagulation…”
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Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation by Maurissen, Lisbeth F.A., Thomassen, M. Christella L. G.D., Nicolaes, Gerry A.F., Dahlbäck, Björn, Tans, Guido, Rosing, Jan, Hackeng, Tilman M.

“…Protein S expresses cofactor activity for activated protein C (APC) by enhancing the APC-catalyzed proteolysis at R306 in factor Va. It is generally accepted…”
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Acquired resistance to activated protein C in breast cancer patients by Nijziel, Marten R., Van Oerle, Rene, Christella, M., Thomassen, L. G. D., Van Pampus, Elisabeth C. M., Hamulyák, Karly, Tans, Guido, Rosing, Jan

“…In 56 women with a lymph‐node‐positive breast carcinoma and 28 matched healthy control subjects, the sensitivity to activated protein C (APC‐sr) was determined…”
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Effect of oral contraceptives on the anticoagulant activity of protein S in plasma by Koenen, Rory R, Christella, M, Thomassen, L G D, Tans, Guido, Rosing, Jan, Hackeng, Tilman M

“…We determined anticoagulant parameters that depend on protein S function in plasma, i.e. the APC-independent anticoagulant activity of protein S (expressed as…”
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Acquired APC resistance and oral contraceptives: differences between two functional tests by Curvers, Joyce, Thomassen, M. Christella L. G. D., Nicolaes, Gerry A. F., Van Oerle, Rene, Hamulyak, Karly, Coenraad HEMKER, H., Tans, Guido, Rosing, Jan

“…Resistance to activated protein C (APC) is often associated with a mutation in factor V (factor VLeiden). Individuals without factor VLeiden who exhibit a…”
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Effects of (pre-)analytical variables on activated protein C resistance determined via a thrombin generation-based assay by Curvers, Joyce, Christella, M, Thomassen, L G D, de Ronde, Hans, Bertina, Rogier M, Rosendaal, Frits R, Tans, Guido, Rosing, Jan

“…The normalized activated protein C sensitivity ratio (nAPC-sr) determined with an assay that quantifies the effect of APC on thrombin formation initiated via…”
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Venous Thrombosis and Changes of Hemostatic Variables during Cross-Sex Hormone Treatment in Transsexual People by Toorians, A. W. F. T., Thomassen, M. C. L. G. D., Zweegman, S., Magdeleyns, E. J. P., Tans, G., Gooren, L. J. G., Rosing, J.

“…The incidence of venous thrombosis associated with estrogen treatment in male-to-female (M→F) transsexuals is considerably higher with administration of oral…”
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Commentary on White Paper The Future of Hormesis: Where Do We Go from Here? Edward J. Calabrese by Thomassen, David G.

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Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test by Curvers, Joyce, Thomassen, M Christella L G D, Rimmer, Janet, Hamulyak, Karly, van der Meer, Jan, Tans, Guido, Preston, F Eric, Rosing, Jan

“…Several hereditary and acquired risk factors for venous thromboembolism (VTE) are associated with impaired down-regulation of thrombin formation via the…”
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Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second‐ and third‐generation oral contraceptives by Rosing, J., Tans, G., Nicolaes, G. A. F., Thomassen, M. C. L. G. D., Van Oerle, R., Van DerPloeg, P. M. E. N., Heijnen, P., Hamulyak, K., Hemker, H. C.

“…Epidemiological studies have shown that women who use third‐generation oral contraceptives (OC) containing desogestrel, gestodene or norgestimate have a higher…”
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Segregation of Platelet Aggregatory and Procoagulant Microdomains in Thrombus Formation: Regulation by Transient Integrin Activation by Munnix, Imke C.A, Kuijpers, Marijke J.E, Auger, Jocelyn, Thomassen, Christella M.L.G.D, Panizzi, Peter, van Zandvoort, Marc A.M, Rosing, Jan, Bock, Paul E, Watson, Steve P, Heemskerk, Johan W.M

“…OBJECTIVE—Platelets play a dual role in thrombosis by forming aggregates and stimulating coagulation. We investigated the commitment of platelets to these…”
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Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals by Nicolaes, G A, Thomassen, M C, Tans, G, Rosing, J, Hemker, H C

“…In this paper we describe the effect of activated protein C (APC) on thrombin generation initiated in platelet-poor plasma via the extrinsic or the intrinsic…”
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Realizing the Potential of the Genome Revolution: The Genomes to Life Program by Frazier, Marvin E., Johnson, Gary M., Thomassen, David G., Oliver, Carl E., Patrinos, Aristides

“…The systems biology revolution is proceeding along multiple pathways as different science agencies and the private sector have adopted strategies suited to…”
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Incorporation of Disulfide Containing Protein Modules into Multivalent Antigenic Conjugates: Generation of Antibodies against the Thrombin-Sensitive Region of Murine Protein S by Van de Vijver, Pieter, Schmitt, Martin, Suylen, Dennis, Scheer, Liesbeth, Thomassen, M. Christella L. G. D, Schurgers, Leon J, Griffin, John H, Koenen, Rory R, Hackeng, Tilman M

“…Antigenic peptide conjugates can be used as vaccines and for the production of antibodies for clinical and research use. A method is presented here for the…”
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Variable Responsiveness of Rat Tracheal Epithelial Cells to Bovine Serum Albumin in Serum-Free Culture by Thomassen, David G.

“…The colony-forming efficiency of rat tracheal epithelial (RTE) cells was determined in serum-free media containing different types of commercially available…”
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Alpha-particles induce preneoplastic transformation of rat tracheal epithelial cells in culture by Thomassen, D G, Seiler, F A, Shyr, L J, Griffith, W C

“…To characterize the potential role of high-l.e.t. radiation in respiratory carcinogenesis, the cytotoxic and transforming potency of 5.5 Me V alpha-particles…”
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