Search Results - "THOMAS, J. R"

Isogeometric finite element data structures based on Bézier extraction of NURBS by Borden, Michael J., Scott, Michael A., Evans, John A., Hughes, Thomas J. R.

“…We present the B'ezier extraction operator and isogeometric Bézier elements for non‐uniform rational B‐Spline (NURBS)‐based isogeometric analysis. The Bézier…”
Get full text

Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours by Middleton, Mark R., Dean, Emma, Evans, Thomas R. J., Shapiro, Geoffrey I., Pollard, John, Hendriks, Bart S., Falk, Martin, Diaz-Padilla, Ivan, Plummer, Ruth

“…Background Berzosertib (formerly M6620, VX-970) is a highly potent and selective, first-in-class inhibitor of ataxia telangiectasia and Rad3-related protein…”
Get full text

Economics of salt-induced land degradation and restoration by Qadir, M., Quillérou, E., Nangia, V., Murtaza, G., Singh, M., Thomas, R.J., Drechsel, P., Noble, A.D.

“…Food security concerns and the scarcity of new productive land have put productivity enhancement of degraded lands back on the political agenda. In such a…”
Get full text

Accuracy of body mass index in diagnosing obesity in the adult general population by Romero-Corral, A, Somers, V.K, Sierra-Johnson, J, Thomas, R.J, Collazo-Clavell, M.L, Korinek, J, Allison, T.G, Batsis, J.A, Sert-Kuniyoshi, F.H, Lopez-Jimenez, F

“…Background: Body mass index (BMI) is the most widely used measure to diagnose obesity. However, the accuracy of BMI in detecting excess body adiposity in the…”
Get full text

Photoionizing feedback in spiral arm molecular clouds by Bending, Thomas J R, Dobbs, Clare L, Bate, Matthew R

“…ABSTRACT We present simulations of a 500 pc2 region, containing gas of mass 4 × 106 M⊙, extracted from an entire spiral galaxy simulation, scaled up in…”
Get full text

Isogeometric finite element data structures based on Bézier extraction of T-splines by Scott, Michael A., Borden, Michael J., Verhoosel, Clemens V., Sederberg, Thomas W., Hughes, Thomas J. R.

“…We develop finite element data structures for T‐splines based on Bézier extraction generalizing our previous work for NURBS. As in traditional finite element…”
Get full text

Fluid–structure interaction analysis of bioprosthetic heart valves: significance of arterial wall deformation by Hsu, Ming-Chen, Kamensky, David, Bazilevs, Yuri, Sacks, Michael S., Hughes, Thomas J. R.

“…We propose a framework that combines variational immersed-boundary and arbitrary Lagrangian–Eulerian methods for fluid–structure interaction (FSI) simulation…”
Get full text

The translation of cell-based therapies: clinical landscape and manufacturing challenges by Heathman, Thomas RJ, Nienow, Alvin W, McCall, Mark J, Coopman, Karen, Kara, Bo, Hewitt, Christopher J

“…Cell-based therapies have the potential to make a large contribution toward currently unmet patient need and thus effective manufacture of these products is…”
Get full text

Isogeometric analysis of the Cahn–Hilliard phase-field model by Gómez, Héctor, Calo, Victor M., Bazilevs, Yuri, Hughes, Thomas J.R.

“…The Cahn–Hilliard equation involves fourth-order spatial derivatives. Finite element solutions are not common because primal variational formulations of…”
Get full text

Provably unconditionally stable, second-order time-accurate, mixed variational methods for phase-field models by Gomez, Hector, Hughes, Thomas J.R.

“…We introduce provably unconditionally stable mixed variational methods for phase-field models. Our formulation is based on a mixed finite element method for…”
Get full text

Thinner biological tissues induce leaflet flutter in aortic heart valve replacements by Johnson, Emily L., Wu, Michael C. H., Xu, Fei, Wiese, Nelson M., Rajanna, Manoj R., Herrema, Austin J., Ganapathysubramanian, Baskar, Hughes, Thomas J. R., Sacks, Michael S., Hsu, Ming-Chen

“…Valvular heart disease has recently become an increasing public health concern due to the high prevalence of valve degeneration in aging populations. For…”
Get full text

An isogeometric approach to cohesive zone modeling by Verhoosel, Clemens V., Scott, Michael A., de Borst, René, Hughes, Thomas J. R.

“…The possibility of enhancing a B‐spline basis with discontinuities by means of knot insertion makes isogeometric finite elements a suitable candidate for…”
Get full text

An immersogeometric variational framework for fluid–structure interaction: Application to bioprosthetic heart valves by Kamensky, David, Hsu, Ming-Chen, Schillinger, Dominik, Evans, John A., Aggarwal, Ankush, Bazilevs, Yuri, Sacks, Michael S., Hughes, Thomas J.R.

“…In this paper, we develop a geometrically flexible technique for computational fluid–structure interaction (FSI). The motivating application is the simulation…”
Get full text

A framework for designing patient‐specific bioprosthetic heart valves using immersogeometric fluid–structure interaction analysis by Xu, Fei, Morganti, Simone, Zakerzadeh, Rana, Kamensky, David, Auricchio, Ferdinando, Reali, Alessandro, Hughes, Thomas J. R., Sacks, Michael S., Hsu, Ming‐Chen

“…Numerous studies have suggested that medical image derived computational mechanics models could be developed to reduce mortality and morbidity due to…”
Get full text

An isogeometric analysis approach to gradient damage models by Verhoosel, Clemens V., Scott, Michael A., Hughes, Thomas J. R., de Borst, René

“…Continuum damage formulations are commonly used for the simulation of diffuse fracture processes. Implicit gradient damage models are employed to avoid the…”
Get full text

A parametric study of the effect of 3D plaque shape on local hemodynamics and implications for plaque instability by Hossain, Shaolie S., Johnson, Michael J., Hughes, Thomas J. R.

“…The vast majority of heart attacks occur when vulnerable plaques rupture, releasing their lipid content into the blood stream leading to thrombus formation and…”
Get full text

Patient-specific vascular NURBS modeling for isogeometric analysis of blood flow by Zhang, Yongjie, Bazilevs, Yuri, Goswami, Samrat, Bajaj, Chandrajit L., Hughes, Thomas J.R.

“…We describe an approach to construct hexahedral solid NURBS (Non-Uniform Rational B-Splines) meshes for patient-specific vascular geometric models from imaging…”
Get full text

Immersogeometric cardiovascular fluid–structure interaction analysis with divergence-conforming B-splines by Kamensky, David, Hsu, Ming-Chen, Yu, Yue, Evans, John A., Sacks, Michael S., Hughes, Thomas J.R.

“…This paper uses a divergence-conforming B-spline fluid discretization to address the long-standing issue of poor mass conservation in immersed methods for…”
Get full text

A coupled momentum method for modeling blood flow in three-dimensional deformable arteries by Figueroa, C. Alberto, Vignon-Clementel, Irene E., Jansen, Kenneth E., Hughes, Thomas J.R., Taylor, Charles A.

“…Blood velocity and pressure fields in large arteries are greatly influenced by the deformability of the vessel. Moreover, wave propagation phenomena in the…”
Get full text

Residual deficits in functional brain activity after chronic cocaine self-administration in rhesus monkeys by Porrino, Linda J, Smith, Hilary R, Beveridge, Thomas J R, Miller, Mack D, Nader, Susan H, Nader, Michael A

“…Previous studies in humans and in animals have shown dramatic effects of cocaine on measures of brain function that persist into abstinence. The purpose of…”
Get full text