Search Results - "THOMAS, J. D"

Resolving the relationships of Paleocene placental mammals by Halliday, Thomas J. D., Upchurch, Paul, Goswami, Anjali

“…ABSTRACT The ‘Age of Mammals’ began in the Paleocene epoch, the 10 million year interval immediately following the Cretaceous–Palaeogene mass extinction. The…”
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Measuring the Hydrogen/Deuterium Exchange of Proteins at High Spatial Resolution by Mass Spectrometry: Overcoming Gas-Phase Hydrogen/Deuterium Scrambling by Rand, Kasper D, Zehl, Martin, Jørgensen, Thomas J. D

“…Conspectus Proteins are dynamic molecules that exhibit conformational flexibility to function properly. Well-known examples of this are allosteric regulation…”
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Highly selective enrichment of phosphorylated peptides using titanium dioxide by Larsen, Martin R, Thingholm, Tine E, Jørgensen, Thomas J D, Jensen, Ole N

“…The characterization of phosphorylated proteins is a challenging analytical task since many of the proteins targeted for phosphorylation are low in abundance…”
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Removal of N‑Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N‑Linked Glycoproteins by Jensen, Pernille Foged, Comamala, Gerard, Trelle, Morten Beck, Madsen, Jeppe Buur, Jørgensen, Thomas J. D, Rand, Kasper. D

“…Protein glycosylation is the most frequent post-translational modification and is present on more than 50% of eukaryotic proteins. Glycosylation covers a wide…”
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The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding by Leth-Espensen, Katrine Z., Kristensen, Kristian K., Kumari, Anni, Winther, Anne-Marie L., Young, Stephen G., Jørgensen, Thomas J. D., Ploug, Michael

“…The complex between lipoprotein lipase (LPL) and its endothelial receptor (GPIHBP1) is responsible for the lipolytic processing of triglyceride-rich…”
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Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry by Paslawski, Wojciech, Mysling, Simon, Thomsen, Karen, Jørgensen, Thomas J. D., Otzen, Daniel E.

“…Neurodegenerative disorders are characterized by the formation of protein oligomers and amyloid fibrils, which in the case of Parkinson’s disease involves the…”
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Traveling-wave ion mobility mass spectrometry of protein complexes: accurate calibrated collision cross-sections of human insulin oligomers by Salbo, Rune, Bush, Matthew F., Naver, Helle, Campuzano, Iain, Robinson, Carol V., Pettersson, Ingrid, Jørgensen, Thomas J. D., Haselmann, Kim F.

“…RATIONALE The collision cross‐section (Ω) of a protein or protein complex ion can be measured using traveling‐wave (T‐wave) ion mobility (IM) mass spectrometry…”
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Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism by Kristensen, Kristian K., Leth-Espensen, Katrine Zinck, Mertens, Haydyn D. T., Birrane, Gabriel, Meiyappan, Muthuraman, Olivecrona, Gunilla, Jørgensen, Thomas J. D., Young, Stephen G., Ploug, Michael

“…The binding of lipoprotein lipase (LPL) to GPIHBP1 focuses the intravascular hydrolysis of triglyceride-rich lipoproteins on the surface of capillary…”
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Surgical management and outcomes of colorectal cancer liver metastases by Morris, E. J. A., Forman, D., Thomas, J. D., Quirke, P., Taylor, E. F., Fairley, L., Cottier the late, B., Poston, G.

“…Background: This population‐based study investigated the frequency of hepatic resections for colorectal cancer metastases across England and their outcome…”
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Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications by Andersen, Camilla, Grønnemose, Anne Louise, Pedersen, Jannik N, Nowak, Jan S, Christiansen, Gunna, Nielsen, Janni, Mulder, Frans A. A, Otzen, Daniel Erik, Jørgensen, Thomas J. D

“…The aggregation of α-synuclein (αSN) and increased oxidative stress leading to lipid peroxidation are pathological characteristics of Parkinson’s disease (PD)…”
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Electrochemical Reduction of Disulfide-Containing Proteins for Hydrogen/Deuterium Exchange Monitored by Mass Spectrometry by Mysling, Simon, Salbo, Rune, Ploug, Michael, Jørgensen, Thomas J. D

“…Characterization of disulfide bond-containing proteins by hydrogen/deuterium exchange monitored by mass spectrometry (HDX-MS) requires reduction of the…”
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Stopping molecular rotation using coherent ultra-low-energy magnetic manipulations by Chadwick, Helen, Somers, Mark F., Stewart, Aisling C., Alkoby, Yosef, Carter, Thomas J. D., Butkovicova, Dagmar, Alexandrowicz, Gil

“…Rotational motion lies at the heart of intermolecular, molecule-surface chemistry and cold molecule science, motivating the development of methods to excite…”
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Ultraviolet Photodissociation of Protonated Peptides and Proteins Can Proceed with H/D Scrambling by Modzel, Maciej, Wollenberg, Daniel T. Weltz, Trelle, Morten Beck, Larsen, Martin R, Jørgensen, Thomas J. D

“…Ultraviolet photodissociation (UVPD) has recently been introduced as an ion activation method for the determination of single-residue deuterium levels in H/D…”
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Protein Hydrogen Exchange Measured at Single-Residue Resolution by Electron Transfer Dissociation Mass Spectrometry by Rand, Kasper D, Zehl, Martin, Jensen, Ole N, Jørgensen, Thomas J. D

“…Because of unparalleled sensitivity and tolerance to protein size, mass spectrometry (MS) has become a popular method for measuring the solution hydrogen…”
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A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase by Kristensen, Kristian K., Midtgaard, Søren Roi, Mysling, Simon, Kovrov, Oleg, Hansen, Lars Bo, Skar-Gislinge, Nicholas, Beigneux, Anne P., Kragelund, Birthe B., Olivecrona, Gunilla, Young, Stephen G., Jørgensen, Thomas J. D., Fong, Loren G., Ploug, Michael

“…The intravascular processing of triglyceride-rich lipoproteins depends on lipoprotein lipase (LPL) and GPIHBP1, a membrane protein of endothelial cells that…”
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Conformational Analysis of Large and Highly Disulfide-Stabilized Proteins by Integrating Online Electrochemical Reduction into an Optimized H/D Exchange Mass Spectrometry Workflow by Trabjerg, Esben, Jakobsen, Rasmus U, Mysling, Simon, Christensen, Søren, Jørgensen, Thomas J. D, Rand, Kasper D

“…Analysis of disulfide-bonded proteins by hydrogen/deuterium exchange mass spectrometry (HDX-MS) requires effective and rapid reduction of disulfide bonds…”
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Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange by Iversen, Rasmus, Mysling, Simon, Hnida, Kathrin, Jørgensen, Thomas J. D., Sollid, Ludvig M.

“…Significance The enzyme transglutaminase 2 (TG2) is the target of autoantibodies characteristic of the gluten-sensitive enteropathy celiac disease, and intact…”
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Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity by Hansen, Soren, Selman, Lana, Palaniyar, Nades, Ziegler, Karel, Brandt, Jette, Kliem, Anette, Jonasson, Maiken, Skjoedt, Mikkel-Ole, Nielsen, Ole, Hartshorn, Kevan, Jørgensen, Thomas J D, Skjødt, Karsten, Holmskov, Uffe

“…Collectins play important roles in the innate immune defense against microorganisms. Recently, a new collectin, collectin 11 (CL-11 or CL-K1), was identified…”
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Attenuated evolution of mammals through the Cenozoic by Goswami, Anjali, Noirault, Eve, Coombs, Ellen J., Clavel, Julien, Fabre, Anne-Claire, Halliday, Thomas J. D., Churchill, Morgan, Curtis, Abigail, Watanabe, Akinobu, Simmons, Nancy B., Beatty, Brian L., Geisler, Jonathan H., Fox, David L., Felice, Ryan N.

“…The Cenozoic diversification of placental mammals is the archetypal adaptive radiation. Yet, discrepancies between molecular divergence estimates and the…”
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Correction: The rapid-tome, a 3D-printed microtome, and an updated hand-sectioning method for high-quality plant sectioning by Thomas, D J, Rainbow, J, Bartley, L E

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