Search Results - "THOMAS, Gwynneth"

Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism by Lord, Caleb C., Thomas, Gwynneth, Brown, J. Mark

“…Dysregulation of lipid metabolism underlies many chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. Therefore, understanding…”
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In vivo metabolite profiling as a means to identify uncharacterized lipase function: Recent success stories within the alpha beta hydrolase domain (ABHD) enzyme family by Thomas, Gwynneth, Brown, Amanda L., Brown, J. Mark

“…Genome sequencing efforts have identified many uncharacterized lipase/esterase enzymes that have potential to be drug targets for metabolic diseases such as…”
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The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome by Thomas, Gwynneth, Betters, Jenna L., Lord, Caleb C., Brown, Amanda L., Marshall, Stephanie, Ferguson, Daniel, Sawyer, Janet, Davis, Matthew A., Melchior, John T., Blume, Lawrence C., Howlett, Allyn C., Ivanova, Pavlina T., Milne, Stephen B., Myers, David S., Mrak, Irina, Leber, Vera, Heier, Christoph, Taschler, Ulrike, Blankman, Jacqueline L., Cravatt, Benjamin F., Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Zimmermann, Robert, Brown, H. Alex, Brown, J. Mark

“…The serine hydrolase α/β hydrolase domain 6 (ABHD6) has recently been implicated as a key lipase for the endocannabinoid 2-arachidonylglycerol (2-AG) in the…”
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Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation by Lord, Caleb C., Ferguson, Daniel, Thomas, Gwynneth, Brown, Amanda L., Schugar, Rebecca C., Burrows, Amy, Gromovsky, Anthony D., Betters, Jenna, Neumann, Chase, Sacks, Jessica, Marshall, Stephanie, Watts, Russell, Schweiger, Martina, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Lathia, Justin D., Sakaguchi, Takuya F., Lehner, Richard, Haemmerle, Guenter, Zechner, Rudolf, Brown, J. Mark

“…Adipose triglyceride lipase (ATGL) and comparative gene identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought…”
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Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis[S] by Goeritzer, Madeleine, Schlager, Stefanie, Radovic, Branislav, Madreiter, Corina T., Rainer, Silvia, Thomas, Gwynneth, Lord, Caleb C., Sacks, Jessica, Brown, Amanda L., Vujic, Nemanja, Obrowsky, Sascha, Sachdev, Vinay, Kolb, Dagmar, Chandak, Prakash G., Graier, Wolfgang F., Sattler, Wolfgang, Brown, J. Mark, Kratky, Dagmar

“…Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator comparative gene identification-58 (CGI-58) strongly increases…”
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Structural mutants of dengue virus 2 transmembrane domains exhibit host-range phenotype by Smith, Katherine M, Nanda, Kavita, Spears, Carla J, Ribeiro, Mariana, Vancini, Ricardo, Piper, Amanda, Thomas, Gwynneth S, Thomas, Malcolm E, Brown, Dennis T, Hernandez, Raquel

“…There are over 700 known arboviruses and at least 80 immunologically distinct types that cause disease in humans. Arboviruses are transmitted among vertebrates…”
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Testing of novel dengue virus 2 vaccines in African green monkeys: safety, immunogenicity, and efficacy by Smith, Katherine M, Nanda, Kavita, Spears, Carla J, Piper, Amanda, Ribeiro, Mariana, Quiles, Michelle, Briggs, Caitlin M, Thomas, Gwynneth S, Thomas, Malcolm E, Brown, Dennis T, Hernandez, Raquel, McCarl, Victoria

“…The immunogenicity and safety of three novel host-range vaccines containing deletions in the transmembrane domain of dengue virus serotype 2 (DV2) E…”
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CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action by LORD, Caleb C, BETTERS, Jenna L, LEE, Richard G, CROOKE, Rosanne M, GRAHAM, Mark J, PARKS, John S, BRASAEMLE, Dawn L, FESSLER, Michael B, BROWN, H. Alex, BROWN, J. Mark, IVANOVA, Pavlina T, MILNE, Stephen B, MYERS, David S, MADENSPACHER, Jennifer, THOMAS, Gwynneth, CHUNG, Soonkyu, MINGXIA LIU, DAVIS, Matthew A

“…Mutations of comparative gene identification 58 (CGI-58) in humans cause Chanarin-Dorfman syndrome, a rare autosomal recessive disease in which excess…”
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Regulation of the alpha beta hydrolase domain (ABHD) protein family in murine and human obesity by Brown, J. Mark, Martinez, Kristina, Betters, Jenna, Shores, Nathan, Rudel, Lawrence L, McIntosh, Michael K, Thomas, Gwynneth

“…Abstract only In the search for factors that regulate obesity and diabetes, we have discovered a novel lipid‐signaling pathway involving the enzyme alpha beta…”
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The serine hydrolase ABHD6 is a critical regulator of the metabolic syndrome by Thomas, Gwynneth Sarah

“…Dysregulation of lipid metabolism underlies many chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. Genes encoding α/β hydrolase…”
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CGI-58’S ABILITY TO REGULATE HEPATIC TRIACYLGLYCEROL METABOLISM DOES NOT REQUIRE ATGL CO-ACTIVATION by Lord, Caleb C., Ferguson, Daniel, Thomas, Gwynneth, Brown, Amanda L., Schugar, Rebecca C., Burrows, Amy, Gromovsky, Anthony D., Betters, Jenna, Neumann, Chase, Sacks, Jessica, Marshall, Stephanie, Watts, Russell, Schweiger, Martina, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Lathia, Justin D., Sakaguchi, Takuya F., Lehner, Richard, Haemmerle, Guenter, Zechner, Rudolf, Brown, J. Mark

“…Adipose Triglyceride Lipase (ATGL) and Comparative Gene Identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought…”
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Regression of cardiac hypertrophies of various origin by Beznak, M, Korecky, B, Thomas, G

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