Search Results - "THOMAS, E. Louise"

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning by Liu, Yi, Basty, Nicolas, Whitcher, Brandon, Bell, Jimmy D, Sorokin, Elena P, van Bruggen, Nick, Thomas, E Louise, Cule, Madeleine

“…Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been…”
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Body Composition Profiling in the UK Biobank Imaging Study by Linge, Jennifer, Borga, Magnus, West, Janne, Tuthill, Theresa, Miller, Melissa R., Dumitriu, Alexandra, Thomas, E. Louise, Romu, Thobias, Tunón, Patrik, Bell, Jimmy D., Dahlqvist Leinhard, Olof

“…Objective This study aimed to investigate the value of imaging‐based multivariable body composition profiling by describing its association with coronary heart…”
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The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism by Frost, Gary, Sleeth, Michelle L., Sahuri-Arisoylu, Meliz, Lizarbe, Blanca, Cerdan, Sebastian, Brody, Leigh, Anastasovska, Jelena, Ghourab, Samar, Hankir, Mohammed, Zhang, Shuai, Carling, David, Swann, Jonathan R., Gibson, Glenn, Viardot, Alexander, Morrison, Douglas, Louise Thomas, E, Bell, Jimmy D.

“…Increased intake of dietary carbohydrate that is fermented in the colon by the microbiota has been reported to decrease body weight, although the mechanism…”
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LEAP2 changes with body mass and food intake in humans and mice by Mani, Bharath K, Puzziferri, Nancy, He, Zhenyan, Rodriguez, Juan A, Osborne-Lawrence, Sherri, Metzger, Nathan P, Chhina, Navpreet, Gaylinn, Bruce, Thorner, Michael O, Thomas, E Louise, Bell, Jimmy D, Williams, Kevin W, Goldstone, Anthony P, Zigman, Jeffrey M

“…Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit…”
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Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults by Chambers, Edward S, Viardot, Alexander, Psichas, Arianna, Morrison, Douglas J, Murphy, Kevin G, Zac-Varghese, Sagen E K, MacDougall, Kenneth, Preston, Tom, Tedford, Catriona, Finlayson, Graham S, Blundell, John E, Bell, Jimmy D, Thomas, E Louise, Mt-Isa, Shahrul, Ashby, Deborah, Gibson, Glen R, Kolida, Sofia, Dhillo, Waljit S, Bloom, Stephen R, Morley, Wayne, Clegg, Stuart, Frost, Gary

“…The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play…”
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Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study by Martin, Susan, Sorokin, Elena P, Thomas, E Louise, Sattar, Naveed, Cule, Madeleine, Bell, Jimmy D, Yaghootkar, Hanieh

“…Fat content and volume of liver and pancreas are associated with risk of diabetes in observational studies; whether these associations are causal is unknown…”
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Measurement of liver iron by magnetic resonance imaging in the UK Biobank population by McKay, Andy, Wilman, Henry R, Dennis, Andrea, Kelly, Matt, Gyngell, Michael L, Neubauer, Stefan, Bell, Jimmy D, Banerjee, Rajarshi, Thomas, E Louise

“…The burden of liver disease continues to increase in the UK, with liver cirrhosis reported to be the third most common cause of premature death. Iron overload,…”
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Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease by Cuthbertson, Daniel J, Shojaee-Moradie, Fariba, Sprung, Victoria S, Jones, Helen, Pugh, Christopher J A, Richardson, Paul, Kemp, Graham J, Barrett, Mark, Jackson, Nicola C, Thomas, E Louise, Bell, Jimmy D, Umpleby, A Margot

“…Non-alcoholic fatty liver disease (NAFLD) is associated with multi-organ (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise is an…”
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Characterisation of liver fat in the UK Biobank cohort by Wilman, Henry R, Kelly, Matt, Garratt, Steve, Matthews, Paul M, Milanesi, Matteo, Herlihy, Amy, Gyngell, Micheal, Neubauer, Stefan, Bell, Jimmy D, Banerjee, Rajarshi, Thomas, E Louise

“…Non-alcoholic fatty liver disease and the risk of progression to steatohepatitis, cirrhosis and hepatocellular carcinoma have been identified as major public…”
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Precision MRI phenotyping enables detection of small changes in body composition for longitudinal cohorts by Whitcher, Brandon, Thanaj, Marjola, Cule, Madeleine, Liu, Yi, Basty, Nicolas, Sorokin, Elena P., Bell, Jimmy D., Thomas, E. Louise

“…Longitudinal studies provide unique insights into the impact of environmental factors and lifespan issues on health and disease. Here we investigate changes in…”
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Non-invasive means of measuring hepatic fat content by Mehta, Sanjeev-R, Thomas, E-Louise, Bell, Jimmy-D, Johnston, Desmond-G, Taylor-Robinson, Simon-D

“…Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat…”
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Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists by Cuthbertson, Daniel J, Irwin, Andrew, Gardner, Chris J, Daousi, Christina, Purewal, Tej, Furlong, Niall, Goenka, Niru, Thomas, E Louise, Adams, Valerie L, Pushpakom, Sudeep P, Pirmohamed, Munir, Kemp, Graham J

“…Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are effective for obese patients with type 2 diabetes mellitus (T2DM) because they concomitantly target…”
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Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis by Sheridan, David A., Shawa, Isaac Thom, Thomas, E. Louise, Felmlee, Daniel J., Bridge, Simon H., Neely, Dermot, Cobbold, Jeremy F., Holmes, Elaine, Bassendine, Margaret F., Taylor-Robinson, Simon D.

“…Lipids play essential roles in the hepatitis C virus (HCV) life cycle and patients with chronic HCV infection display disordered lipid metabolism which…”
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Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts by Atabaki-Pasdar, Naeimeh, Ohlsson, Mattias, Viñuela, Ana, Frau, Francesca, Pomares-Millan, Hugo, Haid, Mark, Jones, Angus G, Thomas, E Louise, Koivula, Robert W, Kurbasic, Azra, Mutie, Pascal M, Fitipaldi, Hugo, Fernandez, Juan, Dawed, Adem Y, Giordano, Giuseppe N, Forgie, Ian M, McDonald, Timothy J, Rutters, Femke, Cederberg, Henna, Chabanova, Elizaveta, Dale, Matilda, Masi, Federico De, Thomas, Cecilia Engel, Allin, Kristine H, Hansen, Tue H, Heggie, Alison, Hong, Mun-Gwan, Elders, Petra J M, Kennedy, Gwen, Kokkola, Tarja, Pedersen, Helle Krogh, Mahajan, Anubha, McEvoy, Donna, Pattou, Francois, Raverdy, Violeta, Häussler, Ragna S, Sharma, Sapna, Thomsen, Henrik S, Vangipurapu, Jagadish, Vestergaard, Henrik, 't Hart, Leen M, Adamski, Jerzy, Musholt, Petra B, Brage, Soren, Brunak, Søren, Dermitzakis, Emmanouil, Frost, Gary, Hansen, Torben, Laakso, Markku, Pedersen, Oluf, Ridderstråle, Martin, Ruetten, Hartmut, Hattersley, Andrew T, Walker, Mark, Beulens, Joline W J, Mari, Andrea, Schwenk, Jochen M, Gupta, Ramneek, McCarthy, Mark I, Pearson, Ewan R, Bell, Jimmy D, Pavo, Imre, Franks, Paul W

“…Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D)…”
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Abdominal imaging associates body composition with COVID-19 severity by Basty, Nicolas, Sorokin, Elena P, Thanaj, Marjola, Srinivasan, Ramprakash, Whitcher, Brandon, Bell, Jimmy D, Cule, Madeleine, Thomas, E Louise

“…The main drivers of COVID-19 disease severity and the impact of COVID-19 on long-term health after recovery are yet to be fully understood. Medical imaging…”
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Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling by Asaturyan, Hykoush A, Basty, Nicolas, Thanaj, Marjola, Whitcher, Brandon, Thomas, E Louise, Bell, Jimmy D

“…The fatty liver index (FLI) is frequently used as a non-invasive clinical marker for research, prognostic and diagnostic purposes. It is also used to stratify…”
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Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation by Martin, Susan, Tyrrell, Jessica, Thomas, E Louise, Bown, Matthew J, Wood, Andrew R, Beaumont, Robin N, Tsoi, Lam C, Stuart, Philip E, Elder, James T, Law, Philip, Houlston, Richard, Kabrhel, Christopher, Papadimitriou, Nikos, Gunter, Marc J, Bull, Caroline J, Bell, Joshua A, Vincent, Emma E, Sattar, Naveed, Dunlop, Malcolm G, Tomlinson, Ian P M, Lindström, Sara, Bell, Jimmy D, Frayling, Timothy M, Yaghootkar, Hanieh

“…Some individuals living with obesity may be relatively metabolically healthy, whilst others suffer from multiple conditions that may be linked to adverse…”
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HDL-apoA-I kinetics in response to 16 wk of exercise training in men with nonalcoholic fatty liver disease by Whyte, Martin B, Shojaee-Moradie, Fariba, Sharaf, Sharaf E, Cuthbertson, Daniel J, Kemp, Graham J, Barrett, Mark, Jackson, Nicola C, Herring, Roselle A, Wright, John, Thomas, E Louise, Bell, Jimmy, Umpleby, A Margot

“…Nonalcoholic fatty liver disease (NAFLD) is characterized by low-circulating concentration of high-density lipoprotein cholesterol (HDL-C) and raised…”
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Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets by Umpleby, A Margot, Shojaee-Moradie, Fariba, Fielding, Barbara, Li, Xuefei, Marino, Andrea, Alsini, Najlaa, Isherwood, Cheryl, Jackson, Nicola, Ahmad, Aryati, Stolinski, Michael, Lovegrove, Julie A, Johnsen, Sigurd, Jeewaka R Mendis, A S, Wright, John, Wilinska, Malgorzata E, Hovorka, Roman, Bell, Jimmy D, Thomas, E Louise, Frost, Gary S, Griffin, Bruce A

“…Dietary sugars are linked to the development of non-alcoholic fatty liver disease (NAFLD) and dyslipidaemia, but it is unknown if NAFLD itself influences the…”
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Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case–control study by Osimo, Emanuele F., Sweeney, Mark, de Marvao, Antonio, Berry, Alaine, Statton, Ben, Perry, Benjamin I., Pillinger, Toby, Whitehurst, Thomas, Cook, Stuart A., O’Regan, Declan P., Thomas, E. Louise, Howes, Oliver D.

“…Cardiovascular diseases are the leading cause of death in schizophrenia. Patients with schizophrenia show evidence of concentric cardiac remodelling (CCR),…”
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