Search Results - "THOMA, Claudio R"

Global Identification of Modular Cullin-RING Ligase Substrates by Emanuele, Michael J., Elia, Andrew E.H., Xu, Qikai, Thoma, Claudio R., Izhar, Lior, Leng, Yumei, Guo, Ailan, Chen, Yi-Ning, Rush, John, Hsu, Paul Wei-Che, Yen, Hsueh-Chi Sherry, Elledge, Stephen J.

“…Cullin-RING ligases (CRLs) represent the largest E3 ubiquitin ligase family in eukaryotes, and the identification of their substrates is critical to…”
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Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance by Schröder, Martin, Renatus, Martin, Liang, Xiaoyou, Meili, Fabian, Zoller, Thomas, Ferrand, Sandrine, Gauter, Francois, Li, Xiaoyan, Sigoillot, Frederic, Gleim, Scott, Stachyra, Therese-Marie, Thomas, Jason R., Begue, Damien, Khoshouei, Maryam, Lefeuvre, Peggy, Andraos-Rey, Rita, Chung, BoYee, Ma, Renate, Pinch, Benika, Hofmann, Andreas, Schirle, Markus, Schmiedeberg, Niko, Imbach, Patricia, Gorses, Delphine, Calkins, Keith, Bauer-Probst, Beatrice, Maschlej, Magdalena, Niederst, Matt, Maher, Rob, Henault, Martin, Alford, John, Ahrne, Erik, Tordella, Luca, Hollingworth, Greg, Thomä, Nicolas H., Vulpetti, Anna, Radimerski, Thomas, Holzer, Philipp, Carbonneau, Seth, Thoma, Claudio R.

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BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma by Weisberg, Ellen, Chowdhury, Basudev, Meng, Chengcheng, Case, Abigail E., Ni, Wei, Garg, Swati, Sattler, Martin, Azab, Abdel Kareem, Sun, Jennifer, Muz, Barbara, Sanchez, Dana, Toure, Anthia, Stone, Richard M., Galinsky, Ilene, Winer, Eric, Gleim, Scott, Gkountela, Sofia, Kedves, Alexia, Harrington, Edmund, Abrams, Tinya, Zoller, Thomas, Vaupel, Andrea, Manley, Paul, Faller, Michael, Chung, BoYee, Chen, Xin, Busenhart, Philipp, Stephan, Christine, Calkins, Keith, Bonenfant, Debora, Thoma, Claudio R., Forrester, William, Griffin, James D.

“…Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling complex termed ncBAF, has been established as a therapeutic…”
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3D cell culture systems modeling tumor growth determinants in cancer target discovery by Thoma, Claudio R., Zimmermann, Miriam, Agarkova, Irina, Kelm, Jens M., Krek, Wilhelm

“…Phenotypic heterogeneity of cancer cells, cell biological context, heterotypic crosstalk and the microenvironment are key determinants of the multistep process…”
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Priming-Dependent Phosphorylation and Regulation of the Tumor Suppressor pVHL by Glycogen Synthase Kinase 3 by Hergovich, Alexander, Lisztwan, Joanna, Thoma, Claudio R., Wirbelauer, Christiane, Barry, Robert E., Krek, Wilhelm

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification and Functional Characterization of pVHL-Dependent Cell Surface Proteins in Renal Cell Carcinoma by Boysen, Gunther, Bausch-Fluck, Damaris, Thoma, Claudio R, Nowicka, Anna M, Stiehl, Daniel P, Cima, Igor, Luu, Van-Duc, von Teichman, Adriana, Hermanns, Thomas, Sulser, Tullio, Ingold-Heppner, Barbara, Fankhauser, Niklaus, Wenger, Roland H, Krek, Wilhelm, Krek, Peter, Wollscheid, Bernd, Moch, Holger

“…The identification of cell surface accessible biomarkers enabling diagnosis, disease monitoring, and treatment of renal cell carcinoma (RCC) is as challenging…”
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Double-trouble in mitosis caused by von Hippel-Lindau tumor-suppressor protein inactivation by Thoma, Claudio R., Toso, Alberto, Meraldi, Patrick, Krek, Wilhelm

“…Comment on: Thoma CR, et al. Nat Cell Biol 2009; 11:994-1001…”
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Structure of the MRAS–SHOC2–PP1C phosphatase complex by Hauseman, Zachary J., Fodor, Michelle, Dhembi, Anxhela, Viscomi, Jessica, Egli, David, Bleu, Melusine, Katz, Stephanie, Park, Eunyoung, Jang, Dong Man, Porter, Kathryn A., Meili, Fabian, Guo, Hongqiu, Kerr, Grainne, Mollé, Sandra, Velez-Vega, Camilo, Beyer, Kim S., Galli, Giorgio G., Maira, Saveur-Michel, Stams, Travis, Clark, Kirk, Eck, Michael J., Tordella, Luca, Thoma, Claudio R., King, Daniel A.

“…RAS–MAPK signalling is fundamental for cell proliferation and is altered in most human cancers 1 – 3 . However, our mechanistic understanding of how RAS…”
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pVHL and GSK3β are components of a primary cilium-maintenance signalling network by Moch, Holger, Krek, Wilhelm, Frew, Ian J, Thoma, Claudio R, Montani, Matteo, Hoerner, Christian R

“…Defects in the structure or function of the primary cilium, an antennae-like structure whose functional integrity has been linked to the suppression of…”
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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance by Schröder, Martin, Renatus, Martin, Liang, Xiaoyou, Meili, Fabian, Zoller, Thomas, Ferrand, Sandrine, Gauter, Francois, Li, Xiaoyan, Sigoillot, Frederic, Gleim, Scott, Stachyra, Therese-Marie, Thomas, Jason R., Begue, Damien, Khoshouei, Maryam, Lefeuvre, Peggy, Andraos-Rey, Rita, Chung, BoYee, Ma, Renate, Pinch, Benika, Hofmann, Andreas, Schirle, Markus, Schmiedeberg, Niko, Imbach, Patricia, Gorses, Delphine, Calkins, Keith, Bauer-Probst, Beatrice, Maschlej, Magdalena, Niederst, Matt, Maher, Rob, Henault, Martin, Alford, John, Ahrne, Erik, Tordella, Luca, Hollingworth, Greg, Thomä, Nicolas H., Vulpetti, Anna, Radimerski, Thomas, Holzer, Philipp, Carbonneau, Seth, Thoma, Claudio R.

“…Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them…”
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Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen by Schukur, Lina, Zimmermann, Tamara, Niewoehner, Ole, Kerr, Grainne, Gleim, Scott, Bauer-Probst, Beatrice, Knapp, Britta, Galli, Giorgio G., Liang, Xiaoyou, Mendiola, Angelica, Reece-Hoyes, John, Rapti, Melivoia, Barbosa, Ines, Reschke, Markus, Radimerski, Thomas, Thoma, Claudio R.

“…MYC oncoprotein is a multifunctional transcription factor that regulates the expression of a large number of genes involved in cellular growth, proliferation…”
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pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation by Frew, Ian J, Thoma, Claudio R, Georgiev, Strahil, Minola, Andrea, Hitz, Manuela, Montani, Matteo, Moch, Holger, Krek, Wilhelm

“…In patients with von Hippel–Lindau (VHL) disease, renal cysts and clear cell renal cell carcinoma (ccRCC) arise from renal tubular epithelial cells containing…”
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miR-28-5p Promotes Chromosomal Instability in VHL-Associated Cancers by Inhibiting Mad2 Translation by HELL, Michael P, THOMA, Claudio R, FANKHAUSER, Niklaus, CHRISTINAT, Yann, WEBER, Thomas C, KREK, Wilhelm

“…Chromosomal instability enables tumor development, enabled in part by aberrant expression of the mitotic checkpoint protein Mad2. Here we identify a novel…”
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Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field by Vulpetti, Anna, Holzer, Philipp, Schmiedeberg, Niko, Imbach-Weese, Patricia, Pissot-Soldermann, Carole, Hollingworth, Gregory J., Radimerski, Thomas, Thoma, Claudio R., Stachyra, Therese-Marie, Wojtynek, Matthias, Maschlej, Magdalena, Chau, Suzanne, Schuffenhauer, Ansgar, Fernández, César, Schröder, Martin, Renatus, Martin

“…In this study, we describe the rapid identification of potent binders for the WD40 repeat domain (WDR) of DCAF1. This was achieved by two rounds of iterative…”
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A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes by Pinch, Benika J, Buckley, Dennis L, Gleim, Scott, Brittain, Scott M, Tandeske, Laura, D'Alessandro, Pier Luca, Hauseman, Zachary J, Lipps, Jennifer, Xu, Lei, Harvey, Edward P, Schirle, Markus, Sprague, Elizabeth R, Forrester, William C, Dovala, Dustin, McGregor, Lynn M, Thoma, Claudio R

“…While there are hundreds of predicted E3 ligases, characterizing their applications for targeted protein degradation has proved challenging. Here, we report a…”
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VHL loss causes spindle misorientation and chromosome instability by Krek, Wilhelm, Hergovich, Alexander, Thoma, Claudio R, Gutbrodt, Katrin L, Reggi, Sabina P, Schraml, Peter, Toso, Alberto, Frew, Ian J, Moch, Holger, Meraldi, Patrick

“…Error-free mitosis depends on fidelity-monitoring checkpoint systems that ensure correct temporal and spatial coordination of chromosome segregation by the…”
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Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia by Schraml, Peter, Frew, Ian J, Thoma, Claudio R, Boysen, Gunther, Struckmann, Kirsten, Krek, Wilhelm, Moch, Holger

“…Renal cysts and clear cell renal cell carcinoma are common clinical manifestations of people with germ-line mutations of the von Hippel–Lindau tumor suppressor…”
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A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications by Thoma, Claudio R, Stroebel, Simon, Rösch, Nora, Calpe, Blaise, Krek, Wilhelm, Kelm, Jens M

“…Cancer cells in vivo are coordinately influenced by an interactive 3D microenvironment. However, identification of drug targets and initial target validations…”
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Genetic deletion of the long isoform of the von Hippel–Lindau tumour suppressor gene product alters microtubule dynamics by Frew, Ian J, Smole, Zlatko, Thoma, Claudio R, Krek, Wilhelm

“…Summary The von Hippel–Lindau tumour suppressor protein (pVHL) controls distinct cellular responses ranging from targeting hypoxia inducible factor α (HIFα)…”
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Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability by Thoma, Claudio R., Matov, Alexandre, Gutbrodt, Katrin L., Hoerner, Christian R., Smole, Zlatko, Krek, Wilhelm, Danuser, Gaudenz

“…Von Hippel-Lindau (VHL) tumor suppressor gene mutations predispose carriers to kidney cancer. The protein pVHL has been shown to interact with microtubules…”
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