Search Results - "THIELE, D. L"

Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I by MCGUIRE, M. J, LIPSKY, P. E, THIELE, D. L

“…The proenzyme activation peptides predicted from cDNAs encoding each of the granule serine proteases synthesized by cytotoxic lymphocytes and myeloid and mast…”
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Virally Infected Hepatocytes Are Resistant to Perforin-Dependent CTL Effector Mechanisms by Kafrouni, Michel I, Brown, Geri R, Thiele, Dwain L

“…Cell-mediated cytotoxicity plays an important role in the clearance of noncytopathic viruses from infected tissues. Perforin-dependent cytotoxic mechanisms…”
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Noise-reducing algorithms do not necessarily provide superior dose optimisation for hepatic lesion detection with multidetector CT by Dobeli, K L, Lewis, S J, Meikle, S R, Thiele, D L, Brennan, P C

“…To compare the dose-optimisation potential of a smoothing filtered backprojection (FBP) and a hybrid FBP/iterative algorithm to that of a standard FBP…”
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Tumor necrosis factor-alpha enhances cytolytic activity of human natural killer cells by Ostensen, ME, Thiele, DL, Lipsky, PE

“…The effect of recombinant tumor necrosis factor-alpha (rTNF alpha) on human natural killer (NK) function was examined. Lysis of both the NK-sensitive K562…”
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Mechanism of L-Leucyl-L-Leucine Methyl Ester-Mediated Killing of Cytotoxic Lymphocytes: Dependence on a Lysosomal Thiol Protease, Dipeptidyl Peptidase I, That is Enriched in These Cells by Thiele, Dwain L., Lipsky, Peter E.

“…Exposure of murine or human lymphocytes to L-leucyl-L-leucine methyl ester (Leu-Leu-OMe) results in selective killing of cytotoxic lymphocytes, whereas helper…”
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Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium by Brown, GR, Thiele, DL, Silva, M, Beutler, B

“…BACKGROUND & AIMS: Adenoviral vectors have been used for gene transfer in the liver but not for gene transfer in intestinal tissue. The aim of this study was…”
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Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester by Thiele, DL, Kurosaka, M, Lipsky, PE

“…The lysosomotropic compound L-leucine methyl ester (Leu-OMe) was utilized to delineate the phenotype of the accessory cells involved in human B and T cell…”
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The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes by Thiele, DL, Lipsky, PE

“…L-Leucyl-L-leucine methyl ester (Leu-Leu-OMe), a dipeptide condensation product of L-leucine methyl ester generated by human monocytes (M phi) or…”
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Amyloid-β Peptide Levels in Brain Are Inversely Correlated with Insulysin Activity Levels in vivo by Miller, Bonnie C., Eckman, Elizabeth A., Sambamurti, Kumar, Dobbs, Nicole, Chow, K. Martin, Eckman, Christopher B., Hersh, Louis B., Thiele, Dwain L.

“…Factors that elevate amyloid-β (Aβ) peptide levels are associated with an increased risk for Alzheimer's disease. Insulysin has been identified as one of…”
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Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells by Thiele, DL, Lipsky, PE

“…L-leucine methyl ester (Leu-OMe) causes lysosomal disruption and death of human monocytes (M phi). In addition, Leu-OMe removed natural killer cell (NK)…”
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Seroprevalence of GB virus C and persistence of RNA and antibody by Gutierrez, Robin A., Dawson, George J., Knigge, Mark F., Melvin, Susan L., Heynen, Cynthia A., Kyrk, Charles R., Young, Charles E., Carrick, Robert J., Schlauder, George G., Surowy, Teresa K., Dille, Bruce J., Coleman, Paul F., Thiele, Dwain L., Lentino, Joseph R., Pachucki, Constance, Mushahwar, Isa K.

“…Exposure to GB virus C (GBV‐C) was determined in several U.S. populations by both reverse‐transcription‐polymerase chain reaction (RT‐PCR) and by an enzyme…”
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T-cell activation and differentiation are regulated by TNF during murine DBA/2 → B6D2F1 intestinal graft-versus-host disease by BROWN, Geri R, THIELE, Dwain L

“…Administration of a tumor necrosis factor (TNF) inhibitor-encoding adenoviral vector decreases the severity of colonic inflammation in a DBA/2-->B6D2F1 murine…”
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Regulation of Cellular Function by Products of Lysosomal Enzyme Activity: Elimination of Human Natural Killer Cells by a Dipeptide Methyl Ester Generated from L-Leucine Methyl Ester by Monocytes or Polymorphonuclear Leukocytes by Thiele, Dwain L., Lipsky, Peter E.

“…L-Leucine methyl ester (Leu-OMe) is a lysosomotropic compound that irreversibly removes natural killer cell (NK) function from human peripheral blood…”
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Hepatic injury due to troglitazone by MALIK, A. H, PRASAD, P, SABOORIAN, M. H, THIELE, D. L, MALET, P. F

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Purification and characterization of dipeptidyl peptidase I from human spleen by McGuire, M J, Lipsky, P E, Thiele, D L

“…The lysosomal hydrolase, dipeptidyl peptidase I (DPPI), was purified from human spleen and its enzymatic activity characterized. The enzyme was purified to…”
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Dipeptidyl peptidase I is enriched in granules of in vitro- and in vivo- activated cytotoxic T lymphocytes by Brown, GR, McGuire, MJ, Thiele, DL

“…Recent studies have suggested that dipeptidyl peptidase I (DPPI) is the major post-translational processing enzyme responsible for generating activated myeloid…”
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Acute sporadic non‐A, non‐B, non‐C, non‐D, non‐E hepatitis by Rochling, F A, Jones, W F, Chau, K, DuCharme, L, Mimms, L T, Moore, B, Scheffel, J, Cuthbert, J A, Thiele, D L

“…Patients presenting with clinical and laboratory features consistent with a diagnosis of acute non‐A, non‐B hepatitis were evaluated for evidence of hepatitis…”
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Apoptosis is induced in cells with cytolytic potential by L-leucyl-L- leucine methyl ester by Thiele, DL, Lipsky, PE

“…Previous studies have demonstrated that the selective toxicity of leucyl-leucine methyl ester (Leu-Leu-OMe) for cytotoxic lymphocytes and myeloid cells is…”
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Major histocompatibility complex-unrestricted cytolytic activity of human T cells. Analysis of precursor frequency and effector phenotype by Patel, SS, Thiele, DL, Lipsky, PE

“…The frequency and phenotype of human T cells that mediate major histocompatibility complex (MHC)-unrestricted cytolysis were analyzed. T cell clones were…”
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Phenotypic and functional characterization of human T cell clones by Patel, SS, Duby, AD, Thiele, DL, Lipsky, PE

“…The capacity of human peripheral blood-derived T cell clones to carry out a variety of functions was examined. T cell clones were generated by stimulating…”
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