Search Results - "THIE, M"

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome by Vrieze, Anne, Van Nood, Els, Holleman, Frits, Salojärvi, Jarkko, Kootte, Ruud S, Bartelsman, Joep F.W.M, Dallinga–Thie, Geesje M, Ackermans, Mariette T, Serlie, Mireille J, Oozeer, Raish, Derrien, Muriel, Druesne, Anne, Van Hylckama Vlieg, Johan E.T, Bloks, Vincent W, Groen, Albert K, Heilig, Hans G.H.J, Zoetendal, Erwin G, Stroes, Erik S, de Vos, Willem M, Hoekstra, Joost B.L, Nieuwdorp, Max

“…Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean…”
Get full text

Effect of Vegan Fecal Microbiota Transplantation on Carnitine‐ and Choline‐Derived Trimethylamine‐N‐Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome by Smits, Loek P., Kootte, Ruud S., Levin, Evgeni, Prodan, Andrei, Fuentes, Susana, Zoetendal, Erwin G., Wang, Zeneng, Levison, Bruce S., Cleophas, Maartje C. P., Kemper, E. Marleen, Dallinga‐Thie, Geesje M., Groen, Albert K., Joosten, Leo A. B., Netea, Mihai G., Stroes, Erik S. G., Vos, Willem M., Hazen, Stanley L., Nieuwdorp, Max

“…Background Intestinal microbiota have been found to be linked to cardiovascular disease via conversion of the dietary compounds choline and carnitine to the…”
Get full text

The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus by Kootte, R. S., Vrieze, A., Holleman, F., Dallinga-Thie, G. M., Zoetendal, E. G., de Vos, W. M., Groen, A. K., Hoekstra, J. B. L., Stroes, E. S., Nieuwdorp, M.

“…Obesity and type 2 diabetes mellitus (T2DM) are attributed to a combination of genetic susceptibility and lifestyle factors. Their increasing prevalence…”
Get full text

Triglyceride-Rich Lipoproteins and Remnants: Targets for Therapy? by Dallinga-Thie, Geesje M., Kroon, Jeffrey, Borén, Jan, Chapman, M. John

“…It is now evident that elevated circulating levels of triglycerides in the non-fasting state, a marker for triglyceride (TG)-rich remnant particles, are…”
Get full text

Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia by Surendran, R. P., Visser, M. E., Heemelaar, S., Wang, J., Peter, J., Defesche, J. C., Kuivenhoven, J. A., Hosseini, M., Péterfy, M., Kastelein, J. J. P., Johansen, C. T., Hegele, R. A., Stroes, E. S. G., Dallinga-Thie, G. M.

“…  Surendran RP, Visser ME, Heemelaar S, Wang J, Peter J, Defesche JC, Kuivenhoven JA, Hosseini M, Péterfy M, Kastelein JJP, Johansen CT, Hegele RA, Stroes…”
Get full text

Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial by de Groot, Pieter F., Nikolic, Tatjana, Imangaliyev, Sultan, Bekkering, Siroon, Duinkerken, Gaby, Keij, Fleur M., Herrema, Hilde, Winkelmeijer, Maaike, Kroon, Jeffrey, Levin, Evgeni, Hutten, Barbara, Kemper, Elles M., Simsek, Suat, Levels, Johannes H. M., van Hoorn, Flora A., Bindraban, Renuka, Berkvens, Alicia, Dallinga-Thie, Geesje M., Davids, Mark, Holleman, Frits, Hoekstra, Joost B. L., Stroes, Erik S. G., Netea, Mihai, van Raalte, Daniël H., Roep, Bart O., Nieuwdorp, Max

“…Aims/hypothesis The pathophysiology of type 1 diabetes has been linked to altered gut microbiota and more specifically to a shortage of intestinal production…”
Get full text

Intestinal Ralstonia pickettii augments glucose intolerance in obesity by Udayappan, Shanthadevi D, Kovatcheva-Datchary, Petia, Bakker, Guido J, Havik, Stefan R, Herrema, Hilde, Cani, Patrice D, Bouter, Kristien E, Belzer, Clara, Witjes, Julia J, Vrieze, Anne, de Sonnaville, Noor, Chaplin, Alice, van Raalte, Daniel H, Aalvink, Steven, Dallinga-Thie, Geesje M, Heilig, Hans G H J, Bergström, Göran, van der Meij, Suzan, van Wagensveld, Bart A, Hoekstra, Joost B L, Holleman, Frits, Stroes, Erik S G, Groen, Albert K, Bäckhed, Fredrik, de Vos, Willem M, Nieuwdorp, Max

“…An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus…”
Get full text

Intestinal microbiota and faecal transplantation as treatment modality for insulin resistance and type 2 diabetes mellitus by Udayappan, S. D., Hartstra, A. V., Dallinga‐Thie, G. M., Nieuwdorp, M.

“…Summary The prevalence of obesity and diabetes mellitus type 2 is increasing rapidly around the globe. Recent insights have generated an entirely new…”
Get full text

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions by Hoeksema, Marten A, Gijbels, Marion JJ, Van den Bossche, Jan, van der Velden, Saskia, Sijm, Ayestha, Neele, Annette E, Seijkens, Tom, Stöger, J Lauran, Meiler, Svenja, Boshuizen, Marieke CS, Dallinga‐Thie, Geesje M, Levels, Johannes HM, Boon, Louis, Mullican, Shannon E, Spann, Nathanael J, Cleutjens, Jack P, Glass, Chris K, Lazar, Mitchell A, de Vries, Carlie JM, Biessen, Erik AL, Daemen, Mat JAP, Lutgens, Esther, de Winther, Menno PJ

“…Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire…”
Get full text

Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy by Schnitzler, Johan G., Bernelot Moens, Sophie J., Tiessens, Feiko, Bakker, Guido J., Dallinga-Thie, Geesje M., Groen, Albert K., Nieuwdorp, Max, Stroes, Erik S.G., Kroon, Jeffrey

“…The inflammatory profile of circulating monocytes is an important biomarker for atherosclerotic plaque vulnerability. Recent research revealed that peripheral…”
Get full text

Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects by Bouter, Kec, Bakker, G J, Levin, E, Hartstra, A V, Kootte, R S, Udayappan, S D, Katiraei, S, Bahler, L, Gilijamse, P W, Tremaroli, V, Stahlman, M, Holleman, F, van Riel, N A W, Verberne, H J, Romijn, J A, Dallinga-Thie, G M, Serlie, M J, Ackermans, M T, Kemper, E M, Willems van Dijk, K, Backhed, F, Groen, A K, Nieuwdorp, M

“…Gut microbiota-derived short-chain fatty acids (SCFAs) have been associated with beneficial metabolic effects. However, the direct effect of oral butyrate on…”
Get full text

Genetic Variant of the Scavenger Receptor BI in Humans by Vergeer, Menno, Korporaal, Suzanne J.A, Franssen, Remco, Meurs, Illiana, Out, Ruud, Hovingh, G. Kees, Hoekstra, Menno, Sierts, Jeroen A, Dallinga-Thie, Geesje M, Motazacker, Mohammad Mahdi, Holleboom, Adriaan G, Van Berkel, Theo J.C, Kastelein, John J.P, Van Eck, Miranda, Kuivenhoven, Jan Albert

“…In a family with high HDL, a genetic mutation was identified. In addition to higher HDL levels, carriers had reduced cholesterol efflux from macrophages,…”
Get full text

Causality of small and large intestinal microbiota in weight regulation and insulin resistance by Scheithauer, Torsten P.M, Dallinga-Thie, Geesje M, de Vos, Willem M, Nieuwdorp, Max, van Raalte, Daniël H

“…Abstract Background The twin pandemics of obesity and Type 2 diabetes (T2D) are a global challenge for health care systems. Changes in the environment,…”
Get full text

Targeting apoC-III and ANGPTL3 in the treatment of hypertriglyceridemia by Nurmohamed, N S, Dallinga-Thie, G M, Stroes, E S G

“…The prevalence of hypertriglyceridemia (HTG) is increasing. Elevated triglyceride (TG) levels are associated with an increased cardiovascular disease (CVD)…”
Get more information

The effect of dapagliflozin on apolipoprotein B and glucose fluxes in patients with type 2 diabetes and well‐controlled plasma LDL cholesterol by Bouter, Kristien E. C., Bommel, Erik J. M., Jansen, Hans, Harskamp, Dewi, Schierbeek, Henk, Ackermans, Mariëtte T., Serlie, Mireille J., Schimmel, Alinda W. M., Nieuwdorp, Max, Dallinga‐Thie, Geesje M., Raalte, Daniël H.

“…Aim To dissect the effects of the sodium‐glucose linked transporter 2 inhibitor dapagliflozin on lipid metabolism and assess whether these effects could…”
Get full text

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels by Trigueros-Motos, Laia, van Capelleveen, Julian C, Torta, Federico, Castaño, David, Zhang, Lin-Hua, Chai, Caryn, Kang, Martin, Dimova, Lidiya G, Schimmel, Alinda W.M, Tietjen, Ian, Radomski, Chris, Tan, Liang Juin, Hwee, Thiam Chung, Narayanaswamy, Pradeep, Wu, Daniel, Dorninger, Fabian, Yakala, Gopala Krishna, Barhdadi, Amina, Angeli, Veronique, Dubé, Marie-Pierre, Berger, Johannes, Dallinga-Thie, Geesje M, Tietge, Uwe J.F, Wenk, Markus R, Hayden, Michael R, Hovingh, G Kees, Singaraja, Roshni R

“…OBJECTIVE—High-density lipoproteins (HDL) are considered to protect against atherosclerosis in part by facilitating the removal of cholesterol from peripheral…”
Get full text

The metabolism of triglyceride-rich lipoproteins revisited: New players, new insight by Dallinga-Thie, Geesje M, Franssen, Remco, Mooij, Hans L, Visser, Maartje E, Hassing, H. Carlijne, Peelman, Frank, Kastelein, John J.P, Péterfy, Miklós, Nieuwdorp, Max

“…Abstract Peripheral lipoprotein lipase (LPL)-mediated lipolysis of triglycerides is the first step in chylomicron/VLDL clearance involving heparan sulfate…”
Get full text

Decreased GPIHBP1 protein levels in visceral adipose tissue partly underlie the hypertriglyceridemic phenotype in insulin resistance by Surendran, R Preethi, Udayyapan, Shanti D, Clemente-Postigo, Mercedes, Havik, Stefan R, Schimmel, Alinda W M, Tinahones, Fransisco, Nieuwdorp, Max, Dallinga-Thie, Geesje M

“…GPIHBP1 is a protein localized at the endothelial cell surface that facilitates triglyceride (TG) lipolysis by binding lipoprotein lipase (LPL). Whether…”
Get full text

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition by Kootte, Ruud S., Levin, Evgeni, Salojärvi, Jarkko, Smits, Loek P., Hartstra, Annick V., Udayappan, Shanti D., Hermes, Gerben, Bouter, Kristien E., Koopen, Annefleur M., Holst, Jens J., Knop, Filip K., Blaak, Ellen E., Zhao, Jing, Smidt, Hauke, Harms, Amy C., Hankemeijer, Thomas, Bergman, Jacques J.G.H.M., Romijn, Hans A., Schaap, Frank G., Olde Damink, Steven W.M., Ackermans, Mariette T., Dallinga-Thie, Geesje M., Zoetendal, Erwin, de Vos, Willem M., Serlie, Mireille J., Stroes, Erik S.G., Groen, Albert K., Nieuwdorp, Max

“…The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect…”
Get full text

Reduced CETP glycosylation and activity in patients with homozygous B4GALT1 mutations by Boogert, Marjolein A.W., Crunelle, Cleo L., Ali, Lubna, Larsen, Lars E., Kuil, Sacha D., Levels, Johannes H.M., Schimmel, Alinda W.M., Konstantopoulou, Vassiliki, Guerin, Maryse, Kuivenhoven, Jan Albert, Dallinga‐Thie, Geesje M., Stroes, Erik S.G., Lefeber, Dirk J., Holleboom, Adriaan G.

“…The importance of protein glycosylation in regulating lipid metabolism is becoming increasingly apparent. We set out to further investigate this by studying…”
Get full text