Search Results - "THIBAUT, Hendrik Jan"

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways by Laporte, Manon, Raeymaekers, Valerie, Van Berwaer, Ria, Vandeput, Julie, Marchand-Casas, Isabel, Thibaut, Hendrik-Jan, Van Looveren, Dominique, Martens, Katleen, Hoffmann, Markus, Maes, Piet, Pöhlmann, Stefan, Naesens, Lieve, Stevaert, Annelies

“…The high transmissibility of SARS-CoV-2 is related to abundant replication in the upper airways, which is not observed for the other highly pathogenic…”
Get full text

The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis by Corsten, Maarten F, Heggermont, Ward, Papageorgiou, Anna-Pia, Deckx, Sophie, Tijsma, Aloys, Verhesen, Wouter, van Leeuwen, Rick, Carai, Paolo, Thibaut, Hendrik-Jan, Custers, Kevin, Summer, Georg, Hazebroek, Mark, Verheyen, Fons, Neyts, Johan, Schroen, Blanche, Heymans, Stephane

“…Viral myocarditis (VM) is an important cause of heart failure and sudden cardiac death in young healthy adults; it is also an aetiological precursor of dilated…”
Get full text

Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein by Strating, Jeroen R.P.M., van der Linden, Lonneke, Albulescu, Lucian, Bigay, Joëlle, Arita, Minetaro, Delang, Leen, Leyssen, Pieter, van der Schaar, Hilde M., Lanke, Kjerstin H.W., Thibaut, Hendrik Jan, Ulferts, Rachel, Drin, Guillaume, Schlinck, Nina, Wubbolts, Richard W., Sever, Navdar, Head, Sarah A., Liu, Jun O., Beachy, Philip A., De Matteis, Maria A., Shair, Matthew D., Olkkonen, Vesa M., Neyts, Johan, van Kuppeveld, Frank J.M.

“…Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this study, we identify ITZ as a broad-spectrum inhibitor of…”
Get full text

Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C by ULFERTS, Rachel, DER LINDEN, Lonneke Van, JAN THIBAUT, Hendrik, LANKE, Kjerstin H. W, LEYSSEN, Pieter, COUTARD, Bruno, DE PALMA, Armando M, CANARD, Bruno, NEYTS, Johan, KUPPEVELD, Frank J. M. Van

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus by Baggen, Jim, Thibaut, Hendrik Jan, Hurdiss, Daniel L, Wahedi, Maryam, Marceau, Caleb D, van Vliet, Arno L W, Carette, Jan E, van Kuppeveld, Frank J M

“…Encephalomyocarditis virus (EMCV) is an animal pathogen and an important model organism, whose receptor requirements are poorly understood. Here, we employed a…”
Get full text

Combating enterovirus replication: State-of-the-art on antiviral research by Thibaut, Hendrik Jan, De Palma, Armando M., Neyts, Johan

“…Enteroviruses form an important genus within the large family of Picornaviridae. They are small, non-enveloped (+)RNA viruses, many of which are important…”
Get full text

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2–infected hamsters, whereas hydroxychloroquine lacks activity by Kaptein, Suzanne J. F., Jacobs, Sofie, Langendries, Lana, Seldeslachts, Laura, ter Horst, Sebastiaan, Liesenborghs, Laurens, Hens, Bart, Vergote, Valentijn, Heylen, Elisabeth, Barthelemy, Karine, Maas, Elke, De Keyzer, Carolien, Bervoets, Lindsey, Rymenants, Jasper, Van Buyten, Tina, Zhang, Xin, Abdelnabi, Rana, Pang, Juanita, Williams, Rachel, Thibaut, Hendrik Jan, Dallmeier, Kai, Boudewijns, Robbert, Wouters, Jens, Augustijns, Patrick, Verougstraete, Nick, Cawthorne, Christopher, Breuer, Judith, Solas, Caroline, Weynand, Birgit, Annaert, Pieter, Spriet, Isabel, Velde, Greetje Vande, Neyts, Johan, Rocha-Pereira, Joana, Delang, Leen

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the globe after its emergence in Wuhan in December 2019. With no specific…”
Get full text

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate by Sanchez-Felipe, Lorena, Vercruysse, Thomas, Sharma, Sapna, Ma, Ji, Lemmens, Viktor, Van Looveren, Dominique, Arkalagud Javarappa, Mahadesh Prasad, Boudewijns, Robbert, Malengier-Devlies, Bert, Liesenborghs, Laurens, Kaptein, Suzanne J. F., De Keyzer, Carolien, Bervoets, Lindsey, Debaveye, Sarah, Rasulova, Madina, Seldeslachts, Laura, Li, Li-Hsin, Jansen, Sander, Yakass, Michael Bright, Verstrepen, Babs E., Böszörményi, Kinga P., Kiemenyi-Kayere, Gwendoline, van Driel, Nikki, Quaye, Osbourne, Zhang, Xin, ter Horst, Sebastiaan, Mishra, Niraj, Deboutte, Ward, Matthijnssens, Jelle, Coelmont, Lotte, Vandermeulen, Corinne, Heylen, Elisabeth, Vergote, Valentijn, Schols, Dominique, Wang, Zhongde, Bogers, Willy, Kuiken, Thijs, Verschoor, Ernst, Cawthorne, Christopher, Van Laere, Koen, Opdenakker, Ghislain, Vande Velde, Greetje, Weynand, Birgit, Teuwen, Dirk E., Matthys, Patrick, Neyts, Johan, Jan Thibaut, Hendrik, Dallmeier, Kai

“…The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development of safe, efficacious and fast-acting vaccines. Several vaccine platforms…”
Get full text

PLA2G16 represents a switch between entry and clearance of Picornaviridae by Staring, Jacqueline, von Castelmur, Eleonore, Blomen, Vincent A., van den Hengel, Lisa G., Brockmann, Markus, Baggen, Jim, Thibaut, Hendrik Jan, Nieuwenhuis, Joppe, Janssen, Hans, van Kuppeveld, Frank J. M., Perrakis, Anastassis, Carette, Jan E., Brummelkamp, Thijn R.

“…The phospholipase PLA2G16 is required for the entry of picornaviruses, and in its absence, virus infection is prevented by a galectin-8-mediated process. The…”
Get full text

Molecular Biology and Inhibitors of Hepatitis A Virus by Debing, Yannick, Neyts, Johan, Thibaut, Hendrik Jan

“…Hepatitis A virus (HAV) is a faeco‐orally transmitted picornavirus and is one of the main causes of acute hepatitis worldwide. An overview of the molecular…”
Get full text

Bypassing pan-enterovirus host factor PLA2G16 by Baggen, Jim, Liu, Yue, Lyoo, Heyrhyoung, van Vliet, Arno L. W., Wahedi, Maryam, de Bruin, Jost W., Roberts, Richard W., Overduin, Pieter, Meijer, Adam, Rossmann, Michael G., Thibaut, Hendrik Jan, van Kuppeveld, Frank J. M.

“…Enteroviruses are a major cause of human disease. Adipose-specific phospholipase A2 (PLA2G16) was recently identified as a pan-enterovirus host factor and…”
Get full text

Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters by Sharma, Sapna, Vercruysse, Thomas, Sanchez-Felipe, Lorena, Kerstens, Winnie, Rasulova, Madina, Bervoets, Lindsey, De Keyzer, Carolien, Abdelnabi, Rana, Foo, Caroline S., Lemmens, Viktor, Van Looveren, Dominique, Maes, Piet, Baele, Guy, Weynand, Birgit, Lemey, Philippe, Neyts, Johan, Thibaut, Hendrik Jan, Dallmeier, Kai

“…Current COVID-19 vaccines are based on prototypic spike sequences from ancestral 2019 SARS-CoV-2 strains. However, the ongoing pandemic is fueled by variants…”
Get full text

Multiplexed multicolor antiviral assay amenable for high-throughput research by Li, Li-Hsin, Chiu, Winston, Huang, Yun-An, Rasulova, Madina, Vercruysse, Thomas, Thibaut, Hendrik Jan, ter Horst, Sebastiaan, Rocha-Pereira, Joana, Vanhoof, Greet, Borrenberghs, Doortje, Goethals, Olivia, Kaptein, Suzanne J. F., Leyssen, Pieter, Neyts, Johan, Dallmeier, Kai

“…To curb viral epidemics and pandemics, antiviral drugs are needed with activity against entire genera or families of viruses. Here, we develop a cell-based…”
Get full text

Enterovirus D68 receptor requirements unveiled by haploid genetics by Baggen, Jim, Thibaut, Hendrik Jan, Staring, Jacqueline, Jae, Lucas T., Liu, Yue, Guo, Hongbo, Slager, Jasper J., de Bruin, Jost W., van Vliet, Arno L. W., Blomen, Vincent A., Overduin, Pieter, Sheng, Ju, de Haan, Cornelis A. M., de Vries, Erik, Meijer, Adam, Rossmann, Michael G., Brummelkamp, Thijn R., van Kuppeveld, Frank J. M.

“…Enterovirus D68 (EV-D68) is an emerging pathogen that can cause severe respiratory disease and is associated with cases of paralysis, especially among…”
Get full text

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid by Sun, Liang, Lee, Hyunwook, Thibaut, Hendrik Jan, Lanko, Kristina, Rivero-Buceta, Eva, Bator, Carol, Martinez-Gualda, Belen, Dallmeier, Kai, Delang, Leen, Leyssen, Pieter, Gago, Federico, San-Félix, Ana, Hafenstein, Susan, Mirabelli, Carmen, Neyts, Johan

“…Enterovirus A71 (EV-A71) is a non-polio neurotropic enterovirus with pandemic potential. There are no antiviral agents approved to prevent or treat EV-A71…”
Get full text

MVA-CoV2-S Vaccine Candidate Neutralizes Distinct Variants of Concern and Protects Against SARS-CoV-2 Infection in Hamsters by Boudewijns, Robbert, Pérez, Patricia, Lázaro-Frías, Adrián, Van Looveren, Dominique, Vercruysse, Thomas, Thibaut, Hendrik Jan, Weynand, Birgit, Coelmont, Lotte, Neyts, Johan, Astorgano, David, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Dallmeier, Kai, Esteban, Mariano, García-Arriaza, Juan

“…To control the coronavirus disease 2019 (COVID-19) pandemic and the emergence of different variants of concern (VoCs), novel vaccines against severe acute…”
Get full text

9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction by Plačková, Pavla, Šála, Michal, Šmídková, Markéta, Dejmek, Milan, Hřebabecký, Hubert, Nencka, Radim, Thibaut, Hendrik-Jan, Neyts, Johan, Mertlíková-Kaiserová, Helena

“…9-Norbornyl-6-chloropurine (NCP) is a representative of a series of antienteroviral bicycle derivatives with selective cytotoxicity towards leukemia cell…”
Get full text

Use of Micro-Computed Tomography to Visualize and Quantify COVID-19 Vaccine Efficiency in Free-Breathing Hamsters by Seldeslachts, Laura, Cawthorne, Christopher, Kaptein, Suzanne F, Boudewijns, Robbert, Thibaut, Hendrik Jan, Sanchez Felipe, Lorena, Sharma, Sapna, Schramm, Georg, Weynand, Birgit, Dallmeier, Kai, Vande Velde, Greetje

“…The SARS-CoV-2 pandemic has impacted the health of humanity after the outbreak in Hubei, China in late December 2019. Ever since, it has taken unprecedented…”
Get more information

Optimized vaccine candidate MVA-S(3P) fully protects against SARS-CoV-2 infection in hamsters by Abdelnabi, Rana, Pérez, Patricia, Astorgano, David, Albericio, Guillermo, Kerstens, Winnie, Thibaut, Hendrik Jan, Coelmont, Lotte, Weynand, Birgit, Labiod, Nuria, Delgado, Rafael, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Neyts, Johan, Dallmeier, Kai, Esteban, Mariano, García-Arriaza, Juan

“…The development of novel optimized vaccines against coronavirus disease 2019 (COVID-19) that are capable of controlling the severe acute respiratory syndrome…”
Get full text

Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP by Albulescu, Lucian, Strating, Jeroen R.P.M., Thibaut, Hendrik Jan, van der Linden, Lonneke, Shair, Matthew D., Neyts, Johan, van Kuppeveld, Frank J.M.

“…•The natural compound OSW-1 is a potent broad spectrum inhibitor of enterovirus replication.•OSW-1 inhibits enterovirus genome replication.•OSW-1 is effective…”
Get full text