Search Results - "THIAN KUI TAN"

Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage by Kui Tan, Thian, Zheng, Guoping, Hsu, Tzu-Ting, Ra Lee, So, Zhang, Jianlin, Zhao, Ye, Tian, Xinrui, Wang, Yiping, Min Wang, Yuan, Cao, Qi, Wang, Ya, Lee, Vincent WS, Wang, Changqi, Zheng, Dong, Alexander, Stephen I, Thompson, Erik, Harris, David C H

“…A pro-fibrotic role of matrix metalloproteinase-9 (MMP-9) in tubular cell epithelial–mesenchymal transition (EMT) is well established in renal fibrosis;…”
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Characterization of murine macrophages from bone marrow, spleen and peritoneum by Wang, Changqi, Yu, Xiao, Cao, Qi, Wang, Ya, Zheng, Guoping, Tan, Thian Kui, Zhao, Hong, Zhao, Ye, Wang, Yiping, Harris, David Ch

“…Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been…”
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Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-β1 in Renal Tubular Epithelial Cells by Zheng, Guoping, Lyons, James Guy, Tan, Thian Kui, Wang, Yiping, Hsu, Tzu-Ting, Min, Danqing, Succar, Lena, Rangan, Gopala K, Hu, Min, Henderson, Beric R, Alexander, Stephen I, Harris, David C.H

“…Epithelial-mesenchymal transition (EMT) plays an important role in organ fibrosis, including that of the kidney. Loss of E-cadherin expression is a hallmark of…”
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Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells by Tan, Thian Kui, Zheng, Guoping, Hsu, Tzu-Ting, Wang, Ying, Lee, Vincent W.S, Tian, Xinrui, Wang, Yiping, Cao, Qi, Wang, Ya, Harris, David C.H

“…As a rich source of pro-fibrogenic growth factors and matrix metalloproteinases (MMPs), macrophages are well-placed to play an important role in renal…”
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By Homing to the Kidney, Activated Macrophages Potently Exacerbate Renal Injury by Wang, Ying, Wang, Yiping, Cai, Qi, Zheng, Guoping, Lee, Vincent W.S, Zheng, Dong, Li, Xiaomei, Tan, Thian Kui, Harris, David C.H

“…Macrophages are important mediators of injury in most types of human kidney diseases; however, the pathogenic importance of both macrophage number and…”
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IL-10/TGF-β-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis by QI CAO, YIPING WANG, HARRIS, David C. H, DONG ZHENG, YAN SUN, YA WANG, LEE, Vincent W. S, GUOPING ZHENG, THIAN KUI TAN, INCE, Jon, ALEXANDER, Stephen I

“…IL-10/TGF-beta-modified macrophages, a subset of activated macrophages, produce anti-inflammatory cytokines, suggesting that they may protect against…”
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DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice by Zhou, Jimmy Jianheng, Wang, Yuan Min, Lee, Vincent W S, Zhang, Geoff Yu, Medbury, Heather, Williams, Helen, Wang, Ya, Tan, Thian Kui, Harris, David C H, Alexander, Stephen I, Durkan, Anne M

“…Studies disrupting the chemokine pathway CX3CL1 (fractalkine)/ CX3CR1 have shown decreased atherosclerosis in animal models but the techniques used to…”
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IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease by QI CAO, CHANGQI WANG, HARRIS, David C. H, YIPING WANG, DONG ZHENG, YA WANG, LEE, Vincent W. S, YUAN MIN WANG, GUOPING ZHENG, THIAN KUI TAN, DI YU, ALEXANDER, Stephen I

“…The kidney contains receptors for the cytokine IL-25, but the effects of IL-25 in CKD are unknown. Here, we induced adriamycin nephropathy in both BALB/c mice…”
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Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease by Zheng, Dong, Cao, Qi, Lee, Vincent W S, Wang, Ya, Zheng, Guoping, Wang, YuanMin, Tan, Thian Kui, Wang, Changqi, Alexander, Stephen I, Harris, David C H, Wang, Yiping

“…Plasmacytoid dendritic cells play important roles in inducing immune tolerance, preventing allograft rejection, and regulating immune responses in both…”
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Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases by Zhao, Hong, Dong, Yanting, Tian, Xinrui, Tan, Thian Kui, Liu, Zhuola, Zhao, Ye, Zhang, Yun, Harris, David Ch, Zheng, Guoping

“…Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to…”
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E-Cadherin/β-Catenin Complex and the Epithelial Barrier by Tian, Xinrui, Liu, Zhuola, Niu, Bo, Zhang, Jianlin, Tan, Thian Kui, Lee, So Ra, Zhao, Ye, Harris, David C. H., Zheng, Guoping

“…E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of…”
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Matrix metalloproteinase 9-dependent Notch signaling contributes to kidney fibrosis through peritubular endothelial-mesenchymal transition by Zhao, Ye, Qiao, Xi, Tan, Thian Kui, Zhao, Hong, Zhang, Yun, Liu, Lixin, Zhang, Jianlin, Wang, Lihua, Cao, Qi, Wang, Yiping, Wang, Ya, Wang, Yuan Min, Lee, Vincent W S, Alexander, Stephen I, Harris, David C H, Zheng, Guoping

“…Endothelial cells are known to contribute to kidney fibrosis via endothelial-mesenchymal transition (EndoMT). Matrix metalloproteinase 9 (MMP-9) is known to be…”
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Association of β-catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF-β1 by Tian, Xinrui, Zhang, Jianlin, Tan, Thian Kui, Lyons, J Guy, Zhao, Hong, Niu, Bo, Lee, So Ra, Tsatralis, Tania, Zhao, Ye, Wang, Ya, Cao, Qi, Wang, Changqi, Wang, Yiping, Lee, Vincent W S, Kahn, Michael, Zheng, Guoping, Harris, David C H

“…Transforming growth factor β1 (TGF-β1) is known to be both anti-inflammatory and profibrotic. Cross-talk between TGF-β/Smad and Wnt/β-catenin pathways in…”
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DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats by Wang, Ya, Wang, Yuan Min, Wang, Yiping, Zheng, Guoping, Zhang, Geoff Yu, Zhou, Jimmy Jianheng, Tan, Thian Kui, Cao, Qi, Hu, Min, Watson, Debbie, Wu, Huiling, Zheng, Dong, Wang, ChangQi, Lahoud, Mireille H, Caminschi, Irina, Harris, David C, Alexander, Stephen I

“…The CD40-CD154 costimulatory pathway has been shown to be critical for both T- and B-cell activation in autoimmune disease. Here, we assessed the effects of…”
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Regulatory T cells require renal antigen recognition through the TCR to protect against injury in nephritis by Wang, Ya, Wang, Yuanmin, Wang, Yiping, Zheng, Guoping, Tan, Thian Kui, Lee, Sora, Zhang, Jianlin, Zhang, Geoff Yu, Hu, Min, Wang, Changqi, Cao, Qi, Zhao, Ye, Wang, Xin Maggie, Alexander, Stephen I, Harris, David C

“…Regulatory T cells (Treg) are important for maintaining immune homeostasis. Adoptive transfer of Tregs is protective in renal disease models in both…”
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DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration by Zhou, Jimmy Jianheng, Wang, Yuan Min, Lee, Vincent Ws, Phoon, Richard Ks, Zhang, Geoff Yu, Wang, Ya, Tan, Thian Kui, Hu, Min, Wang, Lucy Dongwei, Saito, Mitsuru, Sawyer, Andrew, Harris, David C H, Alexander, Stephen I, Durkan, Anne M

“…Monocytes utilise a variety of chemokines to traffic to atherosclerotic plaques. CX3C chemokine ligand 1 (CX3CL1 & Fractalkine) and its receptor CX3CR1 and…”
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Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells by Zheng, Guoping, Lyons, James Guy, Tan, Thian Kui, Wang, Yiping, Hsu, Tzu-Ting, Min, Danqing, Succar, Lena, Rangan, Gopala K, Hu, Min, Henderson, Beric R, Alexander, Stephen I, Harris, David C H

“…Epithelial-mesenchymal transition (EMT) plays an important role in organ fibrosis, including that of the kidney. Loss of E-cadherin expression is a hallmark of…”
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Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells by Zheng, Guoping, Lyons, James Guy, Tan, Thian Kui, Wang, Yiping, Hsu, Tzu-Ting, Min, Danqing, Succar, Lena, Rangan, Gopala K, Hu, Min, Henderson, Beric R, Alexander, Stephen I, Harris, David C.H

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