Search Results - "THERON, J. J"

Immunopathogenesis of Immune Checkpoint Inhibitor-Related Adverse Events: Roles of the Intestinal Microbiome and Th17 Cells by Anderson, Ronald, Theron, Annette J, Rapoport, Bernardo L

“…The advent of novel, innovative, and effective anti-cancer immunotherapies has engendered an era of renewed optimism among cancer specialists and their…”
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Global transcriptomic analysis in avocado nursery trees reveals differential gene expression during asymptomatic infection by avocado sunblotch viroid (ASBVd) by Joubert, M., van den Berg, N., Theron, J., Swart, V.

“…•Transcriptome data were generated for asymptomatic ASBVd-infected avocado trees.•ASBVd infection altered the expression of 631 genes in asymptomatic…”
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Role of the Neutrophil in the Pathogenesis of Advanced Cancer and Impaired Responsiveness to Therapy by Rapoport, Bernardo L, Steel, Helen C, Theron, Annette J, Smit, Teresa, Anderson, Ronald

“…Notwithstanding the well-recognized involvement of chronic neutrophilic inflammation in the initiation phase of many types of epithelial cancers, a growing…”
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Interactions of HIV and Antiretroviral Therapy With Neutrophils and Platelets by Madzime, Morris, Rossouw, Theresa M, Theron, Annette J, Anderson, Ronald, Steel, Helen C

“…Neutrophils are important components of the innate immune system that mediate pathogen defense by multiple processes including phagocytosis, release of…”
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Nanotechnology and water treatment: applications and emerging opportunities by Theron, J, Walker, J A, Cloete, T E

“…Nanotechnology, the engineering and art of manipulating matter at the nanoscale (1-100 nm), offers the potential of novel nanomaterials for treatment of…”
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Pro-Tumorigenic and Thrombotic Activities of Platelets in Lung Cancer by Anderson, Ronald, Rapoport, Bernardo L, Steel, Helen C, Theron, Annette J

“…Aside from their key protective roles in hemostasis and innate immunity, platelets are now recognized as having multifaceted, adverse roles in the…”
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The Role of Transforming Growth Factor Beta-1 in the Progression of HIV/AIDS and Development of Non-AIDS-Defining Fibrotic Disorders by Theron, Annette J, Anderson, Ronald, Rossouw, Theresa M, Steel, Helen C

“…Even after attainment of sustained viral suppression following implementation of highly active antiretroviral therapy, HIV-infected persons continue to…”
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Pro-inflammatory interactions of streptolysin O toxin with human neutrophils in vitro by Joseph, D, Theron, A J, Feldman, C, Anderson, R, Tintinger, G R

“…The recent global resurgence of severe infections caused by the Group A streptococcus (GAS) pathogen, , has focused attention on this microbial pathogen, which…”
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Cigarette Smoking as a Risk Factor for Tuberculosis in Adults: Epidemiology and Aspects of Disease Pathogenesis by Feldman, Charles, Theron, Annette J, Cholo, Moloko C, Anderson, Ronald

“…It has been noted by the World Health Organisation that cases of tuberculosis in 2022 globally numbered 10.6 million, resulting in 1.3 million deaths, such…”
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High Mobility Group Box 1 in Human Cancer by Rapoport, Bernardo L, Steel, Helen C, Theron, Annette J, Heyman, Liezl, Smit, Teresa, Ramdas, Yastira, Anderson, Ronald

“…High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly in the nucleus of quiescent eukaryotic cells, where it is…”
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ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors by Anderson, Ronald, Theron, Annette J, Steel, Helen C, Nel, Jan G, Tintinger, Gregory R

“…This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of…”
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Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function by Anderson, Ronald, Gravett, C. M., Tintinger, G. R., Steel, Helen C., Theron, A. J., Feldman, Charles

“…Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and…”
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Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics by Anderson, Ronald, Cockeran, Riana, Theron, Annette J., Steel, Helen C., Feldman, Charles

“…Macrolide antibiotics possess several, beneficial, secondary properties which complement their primary antimicrobial activity. In addition to high levels of…”
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Pro-Inflammatory Interactions of Dolutegravir with Human Neutrophils in an In Vitro Study by Theron, Annette J, Anderson, Ronald, Madzime, Morris, Rossouw, Theresa M, Steel, Helen C, Meyer, Pieter W A, Cholo, Moloko C, Kwofie, Luyanda L I, Feldman, Charles, Tintinger, Gregory R

“…There is increasing awareness of an association between the uptake of the HIV integrase inhibitor, dolutegravir, in first-line antiretroviral regimens with…”
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Diversity of parasites from Xenopus laevis (Amphibia: Pipidae) and their seasonal rate of infection in selected habitats in the Limpopo Province, South Africa by Mbokane, E. M., Theron, J., Luus-Powel, W. J.

“…This study determined the diversity and seasonality of parasites species of the African clawed frog, ( ), from three localities, namely Modjadjikloof, Mokopane…”
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Contesting schoolification through snapshots of pedagogy-in-participation in early childhood development centres in South Africa by Bipath, Keshni, Theron, Hantie

“…This article attempts to contest schoolification using snapshots of pedagogy-in-participation in ECD centres in South Africa. Educational research confirms…”
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Systemic Immune Dysregulation in Early Breast Cancer Is Associated With Decreased Plasma Levels of Both Soluble Co-Inhibitory and Co-Stimulatory Immune Checkpoint Molecules by Rapoport, Bernardo L, Steel, Helen C, Hlatshwayo, Nomsa, Theron, Annette J, Meyer, Pieter W A, Nayler, Simon, Benn, Carol-Ann, Smit, Teresa, Kwofie, Luyanda L I, Heyman, Liezl, Anderson, Ronald

“…Breast cancer cells exploit the up-regulation or down-regulation of immune checkpoint proteins to evade anti-tumor immune responses. To explore the possible…”
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Pneumolysin activates neutrophil extracellular trap formation by Nel, J. G., Theron, A. J., Durandt, C., Tintinger, G. R., Pool, R., Mitchell, T. J., Feldman, C., Anderson, R.

“…Summary The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil…”
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Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets In Vitro via Interference With Phosphatidylinositol 3-Kinase by Tintinger, Gregory R, Theron, Annette J, Steel, Helen C, Cholo, Moloko C, Nel, Jan G, Feldman, Charles, Anderson, Ronald

“…Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB), concerns remain about the cardiotoxic potential of this agent, albeit…”
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Contrasting Immunopathogenic and Therapeutic Roles of Granulocyte Colony-Stimulating Factor in Cancer by Theron, Annette, Steel, Helen, Rapoport, Bernardo, Anderson, Ronald

“…Tumor cells are particularly adept at exploiting the immunosuppressive potential of neutrophils as a strategy to achieve uncontrolled proliferation and spread…”
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