In Vitro and In Vivo Properties of Dihydrophthalazine Antifolates, a Novel Family of Antibacterial Drugs

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Published in:	Antimicrobial Agents and Chemotherapy Vol. 53; no. 9; pp. 3620 - 3627
Main Authors:	CASPERS, Patrick, BURY, Luc, GAUCHER, Bérangère, HEIM, Jutta, SHAPIRO, Stuart, SIEGRIST, Sibylle, SCHMITT-HOFFMANN, Anne, THENOZ, Laure, URWYLER, Heinrich
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-09-2009 American Society for Microbiology (ASM)
Subjects:	Animals Anti-Bacterial Agents Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cell Survival - drug effects Enterococcus - drug effects Enterococcus - enzymology Enterococcus faecalis Enterococcus faecium Folic Acid Antagonists Folic Acid Antagonists - chemistry Folic Acid Antagonists - pharmacokinetics Folic Acid Antagonists - pharmacology Haemophilus influenzae Haemophilus influenzae - drug effects Haemophilus influenzae - enzymology HeLa Cells Humans Male Mechanisms of Action: Physiological Effects Medical sciences Mice Microbial Sensitivity Tests Molecular Structure Moraxella (Branhamella) catarrhalis - drug effects Moraxella (Branhamella) catarrhalis - enzymology Moraxella catarrhalis Mycobacterium avium Mycobacterium avium - drug effects Mycobacterium avium - enzymology Pharmacology. Drug treatments Phthalazines Phthalazines - chemistry Phthalazines - pharmacokinetics Phthalazines - pharmacology Polymerase Chain Reaction Staphylococcus aureus Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - enzymology Tetrahydrofolate Dehydrogenase - genetics Trimethoprim Trimethoprim - chemistry Trimethoprim - pharmacokinetics Trimethoprim - pharmacology Antifolate Drug In vivo Antibacterial agent Family study In vitro
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Summary:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Corresponding author. Mailing address: Basilea Pharmaceutica International AG, Postfach, CH-4005 Basel, Switzerland. Phone: (41 61) 606-1320. Fax: (41 61) 606-1112. E-mail: patrick.caspers@basilea.com
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00377-09