Search Results - "THEMELI, Maria"

PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses by Fedorov, Victor D, Themeli, Maria, Sadelain, Michel

“…T cell therapies have demonstrated long-term efficacy and curative potential for the treatment of some cancers. However, their use is limited by damage to…”
Get more information

A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization by Drent, Esther, Themeli, Maria, Poels, Renée, de Jong-Korlaar, Regina, Yuan, Huipin, de Bruijn, Joost, Martens, Anton C.M., Zweegman, Sonja, van de Donk, Niels W.C.J., Groen, Richard W.J., Lokhorst, Henk M., Mutis, Tuna

“…Chimeric antigen receptors (CARs) can effectively redirect cytotoxic T cells toward highly expressed surface antigens on tumor cells. The low expression of…”
Get full text

Engineered T cells from induced pluripotent stem cells: from research towards clinical implementation by Netsrithong, Ratchapong, Garcia-Perez, Laura, Themeli, Maria

“…Induced pluripotent stem cell (iPSC)-derived T (iT) cells represent a groundbreaking frontier in adoptive cell therapies with engineered T cells, poised to…”
Get full text

Endometriosis is a risk factor for recurrent pelvic inflammatory disease after tubo-ovarian abscess surgery by Zografou Themeli, Maria, Nirgianakis, Konstantinos, Neumann, Stephanie, Imboden, Sara, Mueller, M. D.

“…Purpose To evaluate the clinical outcomes and prognosis of patients undergoing laparoscopic surgery for tubo-ovarian abscess (TOA) and identify risk factors…”
Get full text

CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia by Naik, Jyoti, Themeli, Maria, de Jong-Korlaar, Regina, Ruiter, Ruud W J, Poddighe, Pino J, Yuan, Huipin, de Bruijn, Joost D, Ossenkoppele, Gert J, Zweegman, Sonja, Smit, Linda, Mutis, Tuna, Martens, Anton C M, van de Donk, Niels W C J, Groen, Richard W J

Get full text

Effect of Religious Fasting in Ramadan on Blood Pressure: Results From LORANS (London Ramadan Study) and a Meta-Analysis by Al-Jafar, Rami, Zografou Themeli, Maria, Zaman, Sadia, Akbar, Sharmin, Lhoste, Victor, Khamliche, Ahlam, Elliott, Paul, Tsilidis, Konstantinos K, Dehghan, Abbas

“…Background Ramadan fasting is practiced by hundreds of millions every year. This ritual practice changes diet and lifestyle dramatically; thus, the effect of…”
Get full text

Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design by Drent, Esther, Poels, Renée, Mulders, Manon J, van de Donk, Niels W C J, Themeli, Maria, Lokhorst, Henk M, Mutis, Tuna

“…Recent clinical advances with chimeric antigen receptor (CAR) T cells have led to the accelerated clinical approval of CD19-CARs to treat acute lymphoblastic…”
Get full text

Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma by Drent, Esther, Groen, Richard W J, Noort, Willy A, Themeli, Maria, Lammerts van Bueren, Jeroen J, Parren, Paul W H I, Kuball, Jürgen, Sebestyen, Zsolt, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W C J, Martens, Anton C M, Lokhorst, Henk M, Mutis, Tuna

“…Adoptive transfer of chimeric antigen receptor-transduced T cells is a promising strategy for cancer immunotherapy. The CD38 molecule, with its high expression…”
Get full text

Preclinical Evaluation of Invariant Natural Killer T Cells Modified with CD38 or BCMA Chimeric Antigen Receptors for Multiple Myeloma by Poels, Renée, Drent, Esther, Lameris, Roeland, Katsarou, Afroditi, Themeli, Maria, van der Vliet, Hans J, de Gruijl, Tanja D, van de Donk, Niels W C J, Mutis, Tuna

“…Due to the CD1d restricted recognition of altered glycolipids, Vα24-invariant natural killer T (iNKT) cells are excellent tools for cancer immunotherapy with a…”
Get full text

Induced Pluripotent Stem Cell (iPSC)–Derived Lymphocytes for Adoptive Cell Immunotherapy: Recent Advances and Challenges by Nianias, Alexandros, Themeli, Maria

Get full text

A Large Ovarian Endometrioma Occupying the Abdominal Cavity in a Postmenopausal Patient: A Case Report by Zografou, Maria Themeli, Naem, Antoine, Laganà, Antonio Simone, Krentel, Harald

“…Endometriosis is defined by the presence of endometrial-like glands and/or stroma outside the uterus. The prevalence of endometriosis in postmenopausal women…”
Get full text

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment by Depreter, Barbara, Weening, Karin E, Vandepoele, Karl, Essand, Magnus, De Moerloose, Barbara, Themeli, Maria, Cloos, Jacqueline, Hanekamp, Diana, Moors, Ine, D'hont, Inge, Denys, Barbara, Uyttebroeck, Anne, Van Damme, An, Dedeken, Laurence, Snauwaert, Sylvia, Goetgeluk, Glenn, De Munter, Stijn, Kerre, Tessa, Vandekerckhove, Bart, Lammens, Tim, Philippé, Jan

“…Immunotherapeutic strategies targeting the rare leukemic stem cell compartment might provide salvage to the high relapse rates currently observed in acute…”
Get full text

Preclinical activity of allogeneic SLAMF7-specific CAR T-cells (UCARTCS1) in multiple myeloma by Korst, Charlotte L B M, O’Neill, Chloe, Bruins, Wassilis S C, Cosovic, Meliha, Twickler, Inoka, Verkleij, Christie P M, Le Clerre, Diane, Themeli, Maria, Chion-Sotinel, Isabelle, Zweegman, Sonja, Galetto, Roman, Mutis, Tuna, van de Donk, Niels W C J

“…BackgroundAutologous BCMA-specific CAR T-cell therapies have substantial activity in multiple myeloma (MM). However, due to logistical limitations and BCMAlow…”
Get full text

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests by Themeli, Maria, Chhatta, Amiet, Boersma, Hester, Prins, Henk Jan, Cordes, Martijn, de Wilt, Edwin, Farahani, Aïda Shahrabi, Vandekerckhove, Bart, van der Burg, Mirjam, Hoeben, Rob C., Staal, Frank J.T., Mikkers, Harald M.M.

“…RAG2 severe combined immune deficiency (RAG2-SCID) is a lethal disorder caused by the absence of functional T and B cells due to a differentiation block. Here,…”
Get full text

Selecting CD7− T cells for CAR T-cell therapy by Themeli, Maria

Get full text

Rapid and Reproducible Differentiation of Hematopoietic and T Cell Progenitors From Pluripotent Stem Cells by Flippe, Léa, Gaignerie, Anne, Sérazin, Céline, Baron, Olivier, Saulquin, Xavier, Themeli, Maria, Guillonneau, Carole, David, Laurent

“…Cell therapy using T cells has revolutionized medical care in recent years but limitations are associated with the difficulty of genome editing of the cells,…”
Get full text

Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene by Kotini, Andriana G, de Stanchina, Elisa, Themeli, Maria, Sadelain, Michel, Papapetrou, Eirini P

“…Human pluripotent stem cells (hPSCs) hold great promise for cell therapy. However, a major concern is the risk of tumor formation by residual undifferentiated…”
Get full text

CD38-targeting antibodies in multiple myeloma: mechanisms of action and clinical experience by Frerichs, Kristine A, Nagy, Noemi Anna, Lindenbergh, Pieter L, Bosman, Patty, Marin Soto, Jhon, Broekmans, Marloes, Groen, Richard W J, Themeli, Maria, Nieuwenhuis, Louise, Stege, Claudia, Nijhof, Inger S, Mutis, Tuna, Zweegman, Sonja, Lokhorst, Henk M, van de Donk, Niels W C J

“…Multiple myeloma (MM) is generally an incurable hematological malignancy with heterogeneous overall survival rates ranging from a few months to more than…”
Get more information

DNA damage and repair in epithelium after allogeneic hematopoietic stem cell transplantation by Themeli, Maria, Spyridonidis, Alexandros

“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) in humans, following hematoablative treatment, results in biological chimeras. In this case, the…”
Get full text

CD38‐specific Chimeric Antigen Receptor Expressing Natural Killer KHYG‐1 Cells: A Proof of Concept for an “Off the Shelf” Therapy for Multiple Myeloma by Stikvoort, Arwen, Schans, Jort, Sarkar, Subhashis, Poels, Renée, Ruiter, Ruud, Naik, Jyoti, Yuan, Huipin, Bruijn, Joost D., Donk, Niels W. C. J., Zweegman, Sonja, Themeli, Maria, Groen, Richard, O'Dwyer, Michael, Mutis, Tuna

“…Chimeric antigen receptor (CAR) T cells are highly successful in the treatment of hematologic malignancies. We recently generated affinity‐optimized CD38CAR T…”
Get full text