Search Results - "THEBAULT, Stephanie"
-
1
TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice
Published in PloS one (02-05-2019)“…A better understanding of the molecular and cellular mechanisms involved in retinal hydro-mineral homeostasis imbalance during diabetic macular edema (DME) is…”
Get full text
Journal Article -
2
Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals
Published in PLoS pathogens (06-09-2022)“…The binding of the SARS-CoV-2 spike to angiotensin-converting enzyme 2 (ACE2) promotes virus entry into the cell. Targeting this interaction represents a…”
Get full text
Journal Article -
3
Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia
Published in The Journal of clinical investigation (01-08-2007)“…Primary hypomagnesemia constitutes a rare heterogeneous group of disorders characterized by renal or intestinal magnesium (Mg(2+)) wasting resulting in…”
Get full text
Journal Article -
4
Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference
Published in Scientific reports (12-10-2017)“…Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural…”
Get full text
Journal Article -
5
Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function
Published in The Journal of clinical investigation (01-06-2007)“…In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has emerged as a promising prognostic marker and putative therapeutic…”
Get full text
Journal Article -
6
Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis
Published in The Journal of clinical investigation (01-09-2013)“…Chondrocytes are the only cells in cartilage, and their death by apoptosis contributes to cartilage loss in inflammatory joint diseases, such as rheumatoid…”
Get full text
Journal Article -
7
Novel Role of Cold/Menthol-sensitive Transient Receptor Potential Melastatine Family Member 8 (TRPM8) in the Activation of Store-operated Channels in LNCaP Human Prostate Cancer Epithelial Cells
Published in The Journal of biological chemistry (25-11-2005)“…Recent cloning of a cold/menthol-sensitive TRPM8 channel (transient receptor potential melastatine family member 8) from rodent sensory neurons has provided…”
Get full text
Journal Article -
8
TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL
Published in Scientific reports (27-01-2016)“…Translationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and cancer, however without the typical Bcl2 family members’ structure…”
Get full text
Journal Article -
9
The hormone prolactin is a novel, endogenous trophic factor able to regulate reactive glia and to limit retinal degeneration
Published in The Journal of neuroscience (29-01-2014)“…Retinal degeneration is characterized by the progressive destruction of retinal cells, causing the deterioration and eventual loss of vision. We explored…”
Get full text
Journal Article -
10
High Levels of Serum Prolactin Protect Against Diabetic Retinopathy by Increasing Ocular Vasoinhibins
Published in Diabetes (New York, N.Y.) (01-12-2010)“…Increased retinal vasopermeability (RVP) occurs early in diabetes and is crucial for the development of sight-threatening proliferative diabetic retinopathy…”
Get full text
Journal Article -
11
Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death
Published in EBioMedicine (01-05-2016)“…The identification of pathways necessary for retinal pigment epithelium (RPE) function is fundamental to uncover therapies for blindness. Prolactin (PRL)…”
Get full text
Journal Article -
12
Prolactin-derived vasoinhibins increase anxiety- and depression-related behaviors
Published in Psychoneuroendocrinology (01-06-2014)“…Summary The hormone prolactin (PRL) regulates neuroendocrine and emotional stress responses. It is found in the hypothalamus, where the protein is partially…”
Get full text
Journal Article -
13
Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells
Published in Cancer research (Chicago, Ill.) (15-02-2006)“…One major clinical problem with prostate cancer is the cells' ability to survive and proliferate upon androgen withdrawal. Because Ca2+ is central to growth…”
Get full text
Journal Article -
14
Molecular determinants of permeation through the cation channel TRPM6
Published in Cell calcium (Edinburgh) (01-06-2007)“…Abstract TRPM6 and its closest relative TRPM7 are members of the Transient Receptor Potential Melastatin (TRPM) subfamily of cation channels and are known to…”
Get full text
Journal Article -
15
Vasoinhibins: novel inhibitors of ocular angiogenesis
Published in American journal of physiology: endocrinology and metabolism (01-10-2008)“…Disruption of the quiescent state of blood vessels in the retina leads to aberrant vasopermeability and angiogenesis, the major causes of vision loss in…”
Get more information
Journal Article -
16
Requirement of phosphorylatable endothelial nitric oxide synthase at Ser-1177 for vasoinhibin-mediated inhibition of endothelial cell migration and proliferation in vitro
Published in Endocrine (01-03-2014)“…Endothelial nitric oxide synthase (eNOS)-derived nitric oxide is a major vasorelaxing factor and a mediator of vasopermeability and angiogenesis. Vasoinhibins,…”
Get full text
Journal Article -
17
Vasoinhibins regulate the inner and outer blood-retinal barrier and limit retinal oxidative stress
Published in Frontiers in cellular neuroscience (20-10-2014)“…Vasoinhibins are prolactin fragments present in the retina, where they have been shown to prevent the hypervasopermeability associated with diabetes. Enhanced…”
Get full text
Journal Article -
18
Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators
Published in Cell calcium (Edinburgh) (01-03-2007)“…Abstract One of the best-studied temperature-gated channels is transient receptor potential melastatin 8 (TRPM8), which is activated by cold and cooling…”
Get full text
Journal Article -
19
Prolactin in ovarian follicular fluid stimulates endothelial cell proliferation
Published in Journal of vascular research (01-01-2010)“…Angiogenesis is essential for the growth and maturation of the ovarian follicle and its transition into the corpus luteum. In addition to the main…”
Get more information
Journal Article -
20
Peptide Hormone Regulation of Angiogenesis
Published in Physiological reviews (01-10-2009)“…Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, Qro., México It is now apparent that regulation of…”
Get full text
Journal Article