Search Results - "THASTRUP, Jacob"

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation by Thastrup, Jacob O, Rafiqi, Fatema H, Vitari, Alberto C, Pozo-Guisado, Eulalia, Deak, Maria, Mehellou, Youcef, Alessi, Dario R

“…Mutations in the WNK [with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has…”
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Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine by Jeppesen, Maria, Hagel, Grith, Glenthoj, Anders, Vainer, Ben, Ibsen, Per, Harling, Henrik, Thastrup, Ole, Jørgensen, Lars N, Thastrup, Jacob

“…Chemotherapy treatment of cancer remains a challenge due to the molecular and functional heterogeneity displayed by tumours originating from the same cell…”
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The cancer angiogenesis co-culture assay: In vitro quantification of the angiogenic potential of tumoroids by Truelsen, Sarah Line Bring, Mousavi, Nabi, Wei, Haoche, Harvey, Lucy, Stausholm, Rikke, Spillum, Erik, Hagel, Grith, Qvortrup, Klaus, Thastrup, Ole, Harling, Henrik, Mellor, Harry, Thastrup, Jacob

“…The treatment response to anti-angiogenic agents varies among cancer patients and predictive biomarkers are needed to identify patients with resistant cancer…”
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Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient‐derived spheroid cultures by Árnadóttir, Sigrid S., Jeppesen, Maria, Lamy, Philippe, Bramsen, Jesper B., Nordentoft, Iver, Knudsen, Michael, Vang, Søren, Madsen, Mogens R., Thastrup, Ole, Thastrup, Jacob, L. Andersen, Claus

“…Patient‐derived in vitro cultures of colorectal cancer (CRC) may help guide treatment strategies prior to patient treatment. However, most previous studies…”
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Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress by Zagórska, Anna, Pozo-Guisado, Eulalia, Boudeau, Jérôme, Vitari, Alberto C, Rafiqi, Fatema H, Thastrup, Jacob, Deak, Maria, Campbell, David G, Morrice, Nick A, Prescott, Alan R, Alessi, Dario R

“…Mutations within the WNK1 (with-no-K[Lys] kinase-1) gene cause Gordon's hypertension syndrome. Little is known about how WNK1 is regulated. We demonstrate that…”
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In Vitro Coculture Assays of Angiogenesis by Wei, Haoche, Sundararaman, Ananthalakshmy, Truelsen, Sarah Line Bring, Gurevich, David, Thastrup, Jacob, Mellor, Harry

“…During angiogenesis, endothelial cells must undergo a coordinated set of morphological changes in order to form a new vessel. There is a need for endothelial…”
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Application of digital image analysis on histological images of a murine embryoid body model for monitoring endothelial differentiation by Mousavi, Nabi, Raft, Marie Birkvig, Truelsen, Sarah Line Bring, Timmermans, Vera, Thastrup, Jacob, Heegaard, Steffen

“…The in vitro 3D model established from murine pluripotential stem cells (i.e., embryoid bodies (EBs)) is a dynamic model for endothelial differentiation. The…”
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3D in vitro system for measuring treatment responses to immunotherapy in CRC patients by Block, Andreas, Stamm, Hauke, Temovski, Tamara Sutus, Konczalla, Leonie, Brauneck, Franziska, Stange, Inke, Koellmann, Sandra, Li, Jun, Perez, Daniel R., Thastrup, Jacob, Wellbrock, Jasmin, Fiedler, Walter M., Kupper, Juergen, Sturmheit, Tabea

“…Abstract only e15114 Background: Current clinical guidelines for the treatment of cancer patients mainly rely on intrinsic characteristics of a given tumor,…”
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Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1 by Vitari, Alberto C, Thastrup, Jacob, Rafiqi, Fatema H, Deak, Maria, Morrice, Nick A, Karlsson, Håkan K R, Alessi, Dario R

“…The SPAK (STE20/SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase-1) kinases interact and phosphorylate NKCC1 (Na+-K+-2Cl-…”
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Abstract 2906: Characterization of genetic intratumor heterogeneity of colorectal cancer and matching organoids by Arnadottir, Sigrid S., Jeppesen, Maria, Lamy, Philippe, Nordentoft, Iver, Knudsen, Michael, Vang, Søren, Madsen, Mogens R., Thastrup, Jacob, Thastrup, Ole, Andersen, Claus L.

“…Abstract Background: In the recent years it has become evident that intratumor heterogeneity of solid tumors, such as colorectal cancer (CRC), complicates…”
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Abstract 2020: Spheroid culture of primary colorectal cancer cells from liver metastases as an in vitro model of patient tumors by Jeppesen, Maria, Hagel, Grith, Vainer, Ben, Harling, Henrik, Thastrup, Ole, Jorgensen, Lars Nannestad, Thastrup, Jacob

“…Abstract More than 65 % of patients with colorectal cancer require chemotherapeutic treatment during the course of their disease. However, colorectal tumors…”
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KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma by Mousavi, Nabi, Truelsen, Sarah Line Bring, Hagel, Grith, Jorgensen, Lars Nannestad, Harling, Henrik, Timmermans, Vera, Melchior, Linea Cecilie, Thysen, Anna Hammerich, Heegaard, Steffen, Thastrup, Jacob

“…Summary The aim of the present study was to characterize a patient‐derived in vitro 3D model (ie tumoroid) established from colorectal adenocarcinoma. This…”
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Abstract 2718: Spheroid culture of colorectal cancer cells from patient tumor tissue preserves important cellular characteristics of the parental tumor by Jeppesen, Maria, Hagel, Grith, Glenthoj, Anders, Thastrup, Ole, Jorgensen, Lars Nannestad, Thastrup, Jacob

“…Abstract At the time of diagnosis more than 65% of patients with colorectal cancer have advanced disease and require chemotherapeutic treatment. However,…”
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Structural insights into the recognition of substrates and activators by the OSR1 kinase by Villa, Fabrizio, Goebel, Jürgen, Rafiqi, Fatema H, Deak, Maria, Thastrup, Jacob, Alessi, Dario R, van Aalten, Daan M F

“…The oxidative‐stress‐responsive kinase 1 (OSR1) and the STE20/SPS1‐related proline/alanine‐rich kinase (SPAK) are key enzymes in a signalling cascade…”
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c-Jun NH2-terminal kinase 2 is required for ras transformation independently of activator protein 1 by NIELSEN, Christina, THASTRUP, Jacob, BØTTZAUW, Trine, JÄÄTTELÄ, Marja, KALLUNKI, Tuula

“…Active Ras oncogene is expressed in approximately 30% of human cancers. Yet, very little is known about the molecular mechanisms responsible for its…”
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Solid-Phase Synthesis of Smac Peptidomimetics Incorporating Triazoloprolines and Biarylalanines by Le Quement, Sebastian T, Ishoey, Mette, Petersen, Mette T, Thastrup, Jacob, Hagel, Grith, Nielsen, Thomas E

“…Apoptotic induction mechanisms are of crucial importance for the general homeostasis of multicellular organisms. In cancer the apoptotic pathways are…”
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c-Jun NH sub(2)-Terminal Kinase 2 Is Required for Ras Transformation Independently of Activator Protein 1 by Nielsen, Christina, Thastrup, Jacob, Boettzauw, Trine, Jaeaettelae, Marja, Kallunki, Tuula

“…Active Ras oncogene is expressed in similar to 30% of human cancers. Yet, very little is known about the molecular mechanisms responsible for its transforming…”
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Identification of nucleolar effects in JNK-deficient cells by Mialon, Antoine, Thastrup, Jacob, Kallunki, Tuula, Mannermaa, Leni, Westermarck, Jukka, Holmström, Tim H.

“…The c-Jun N-terminal kinase (JNK) signalling pathway has an established role in cellular stress signalling, cell survival and tumorigenesis. Here, we…”
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