Search Results - "THAN, Manuel E"

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import by Dormann, Dorothee, Rodde, Ramona, Edbauer, Dieter, Bentmann, Eva, Fischer, Ingeborg, Hruscha, Alexander, Than, Manuel E, Mackenzie, Ian R A, Capell, Anja, Schmid, Bettina, Neumann, Manuela, Haass, Christian

“…Mutations in fused in sarcoma ( FUS ) are a cause of familial amyotrophic lateral sclerosis (fALS). Patients carrying point mutations in the C‐terminus of FUS…”
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Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish by Reichwald, Kathrin, Petzold, Andreas, Koch, Philipp, Downie, Bryan R., Hartmann, Nils, Pietsch, Stefan, Baumgart, Mario, Chalopin, Domitille, Felder, Marius, Bens, Martin, Sahm, Arne, Szafranski, Karol, Taudien, Stefan, Groth, Marco, Arisi, Ivan, Weise, Anja, Bhatt, Samarth S., Sharma, Virag, Kraus, Johann M., Schmid, Florian, Priebe, Steffen, Liehr, Thomas, Görlach, Matthias, Than, Manuel E., Hiller, Michael, Kestler, Hans A., Volff, Jean-Nicolas, Schartl, Manfred, Cellerino, Alessandro, Englert, Christoph, Platzer, Matthias

“…The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast…”
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Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism by Dahms, Sven O., Arciniega, Marcelino, Steinmetzer, Torsten, Huber, Robert, Than, Manuel E.

“…Proprotein convertases (PCs) are highly specific proteases required for the proteolytic modification of many secreted proteins. An unbalanced activity of these…”
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Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans by Sabala, Izabela, Jagielska, Elzbieta, Bardelang, Philip T, Czapinska, Honorata, Dahms, Sven O, Sharpe, Jason A, James, Richard, Than, Manuel E, Thomas, Neil R, Bochtler, Matthias

“…Staphylococcus simulans biovar staphylolyticus lysostaphin efficiently cleaves Staphylococcus aureus cell walls. The protein is in late clinical trials as a…”
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Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein by Dahms, Sven O, Hoefgen, Sandra, Roeser, Dirk, Schlott, Bernhard, Gührs, Karl-Heinz, Than, Manuel E

“…The amyloid precursor protein (APP) is the key player in Alzheimer's disease pathology, yet APP and its analogues are also essential for neuronal development…”
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The crystal structure of the proprotein processing proteinase furin explains its stringent specificity by Bode, Wolfram, Than, Manuel E, Henrich, Stefan, Cameron, Angus, Bourenkov, Gleb P, Kiefersauer, Reiner, Huber, Robert, Lindberg, Iris

“…In eukaryotes, many essential secreted proteins and peptide hormones are excised from larger precursors by members of a class of calcium-dependent…”
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Analysis of the overall structure of the multi-domain amyloid precursor protein (APP) by Coburger, Ina, Dahms, Sven O, Roeser, Dirk, Gührs, Karl-Heinz, Hortschansky, Peter, Than, Manuel E

“…The amyloid precursor protein (APP) and its processing by the α-, β- and γ-secretases is widely believed to play a central role during the development of…”
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Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33 by Dislich, Bastian, Than, Manuel E, Lichtenthaler, Stefan F

“…SNX33 (sorting nexin 33) is a homologue of the endocytic protein SNX9 and has been implicated in actin polymerization and the endocytosis of the amyloid…”
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The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domain by Honarmand Ebrahimi, Kourosh, Dienemann, Christian, Hoefgen, Sandra, Than, Manuel E, Hagedoorn, Peter-Leon, Hagen, Wilfred R

“…The ubiquitous 24-meric iron-storage protein ferritin and multicopper oxidases such as ceruloplasmin or hephaestin catalyze oxidation of Fe(II) to Fe(III),…”
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The Crystal Structure of Death Receptor 6 (DR6): A Potential Receptor of the Amyloid Precursor Protein (APP) by Kuester, Miriam, Kemmerzehl, Steffen, Dahms, Sven O., Roeser, Dirk, Than, Manuel E.

“…Death receptors belong to the tumor necrosis factor receptor (TNFR) super family and are intimately involved in the signal transduction during apoptosis,…”
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Regulation of Son of sevenless by the membrane-actin linker protein ezrin by Geißler, Katja J., Jung, M. Juliane, Riecken, Lars Björn, Sperka, Tobias, Cui, Yan, Schacke, Stephan, Merkel, Ulrike, Markwart, Robby, Rubio, Ignacio, Than, Manuel E., Breithaupt, Constanze, Peuker, Sebastian, Seifert, Reinhard, Kaupp, Ulrich Benjamin, Herrlich, Peter, Morrison, Helen

“…Receptor tyrosine kinases participate in several signaling pathways through small G proteins such as Ras (rat sarcoma). An important component in the…”
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X‑ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket by Dahms, Sven O, Hardes, Kornelia, Steinmetzer, Torsten, Than, Manuel E

“…The proprotein convertase furin is a highly specific serine protease modifying and thereby activating proteins in the secretory pathway by proteolytic…”
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The 1.9-Å Crystal Structure of the Noncollagenous (NC1) Domain of Human Placenta Collagen IV Shows Stabilization via a Novel Type of Covalent Met-Lys Cross-Link by Than, Manuel E., Henrich, Stefan, Huber, Robert, Ries, Albert, Mann, Karlheinz, Kühn, Klaus, Timpl, Rupert, Bourenkov, Gleb P., Batunik, Hans D., Bode, Wolfram

“…Triple-helical collagen IV protomers associate through their N- and C-termini forming a three-dimensional network, which provides basement membranes with an…”
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Crystal structure of the first dissimilatory nitrate reductase at 1.9 Å solved by MAD methods by Dias, João M, Than, Manuel E, Humm, Andreas, Huber, Robert, Bourenkov, Gleb P, Bartunik, Hans D, Bursakov, Sergey, Calvete, Juan, Caldeira, Jorge, Carneiro, Carla, Moura, José JG, Moura, Isabel, Romão, Maria J

“…Background: The periplasmic nitrate reductase (NAP) from the sulphate reducing bacterium Desulfovibrio desulfuricans ATCC 27774 is induced by growth on nitrate…”
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The structural biology of the amyloid precursor protein APP - a complex puzzle reveals its multi-domain architecture by Coburger, Ina, Hoefgen, Sandra, Than, Manuel E

“…The amyloid precursor protein (APP) and its processing are widely believed to be central for the etiology of Alzheimer's disease (AD) and appear essential for…”
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Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor by Dahms, Sven O, Jiao, Guan-Sheng, Than, Manuel E

“…Proprotein convertases (PCs) represent highly selective serine proteases that activate their substrates upon proteolytic cleavage. Their inhibition is a…”
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The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain by Hoefgen, Sandra, Dahms, Sven O., Oertwig, Kathrin, Than, Manuel E.

“…The amyloid precursor protein (APP) and its proteolytic cleavage product Aβ are widely believed to be central to the etiology of Alzheimer's disease (AD). APP…”
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X‑ray Structures of Human Furin in Complex with Competitive Inhibitors by Dahms, Sven O, Hardes, Kornelia, Becker, Gero L, Steinmetzer, Torsten, Brandstetter, Hans, Than, Manuel E

“…Furin inhibitors are promising therapeutics for the treatment of cancer and numerous infections caused by bacteria and viruses, including the highly lethal…”
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A novel free-mounting system for protein crystals: transformation and improvement of diffraction power by accurately controlled humidity changes by Kiefersauer, Reiner, Than, Manuel E., Dobbek, Holger, Gremer, Lothar, Melero, Marcos, Strobl, Stefan, Dias, João M., Soulimane, Tewfik, Huber, Robert

“…A novel device for capillary‐free mounting of protein crystals is described. A controlled stream of air allows an accurate adjustment of the humidity at the…”
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Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow by Mishra, Vartika, Re, Diane B., Le Verche, Virginia, Alvarez, Mariano J., Vasciaveo, Alessandro, Jacquier, Arnaud, Doulias, Paschalis-Tomas, Greco, Todd M., Nizzardo, Monica, Papadimitriou, Dimitra, Nagata, Tetsuya, Rinchetti, Paola, Perez-Torres, Eduardo J., Politi, Kristin A., Ikiz, Burcin, Clare, Kevin, Than, Manuel E., Corti, Stefania, Ischiropoulos, Harry, Lotti, Francesco, Califano, Andrea, Przedborski, Serge

“…Cell-to-cell communications are critical determinants of pathophysiological phenotypes, but methodologies for their systematic elucidation are lacking. Herein,…”
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