Search Results - "THAMS, P"

Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets by THAMS, P, CAPITO, K

“…To assess the possible importance of saturated fatty acids in glucose amplification of K+ATP channel-independent insulin secretion. Insulin release from…”
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L-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide by THAMS, P, CAPITO, K

“…The mechanism of L-arginine stimulation of glucose-induced insulin secretion from mouse pancreatic islets was studied. At 16.7 mmol/l glucose, L-arginine (10…”
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Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated histone modifications by Ibarra Urizar, Adriana, Prause, Michala, Wortham, Matthew, Sui, Yinghui, Thams, Peter, Sander, Maike, Christensen, Gitte Lund, Billestrup, Nils

“…Decreased insulin secretory capacity in Type 2 diabetes mellitus is associated with beta-cell dedifferentiation and inflammation. We hypothesize that prolonged…”
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Phorbol-ester-induced down-regulation of protein kinase C in mouse pancreatic islets. Potentiation of phase 1 and inhibition of phase 2 of glucose-induced insulin secretion by Thams, P, Capito, K, Hedeskov, C J, Kofod, H

“…The influence of down-regulation of protein kinase C on glucose-induced insulin secretion was studied. A 22-24 h exposure of mouse pancreatic islets to the…”
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Mechanism of fat-induced attenuation of glucose-induced insulin secretion from mouse pancreatic islets by CAPITO, K, REINSMARK, R, THAMS, P

“…In order to investigate the mechanism behind fat-induced inhibition of glucose-induced insulin secretion a selection of enzymes that may participate in…”
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Role of protein kinase C and Ca2+ in glucose-induced sensitization/desensitization of insulin secretion by Thams, P

“…The role of protein kinase C and Ca2+ in glucose-induced sensitization/desensitization of insulin secretion was studied. A 22-24 h exposure of mouse pancreatic…”
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Cytosolic ratios of free [NADPH]/[NADP+] and [NADH]/[NAD+] in mouse pancreatic islets, and nutrient-induced insulin secretion by Hedeskov, C J, Capito, K, Thams, P

“…When the extracellular concentration of glucose was raised from 3 mM to 7 mM (the concentration interval in which beta-cell depolarization and the major…”
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Fat-induced changes in mouse pancreatic islet insulin secretion, insulin biosynthesis and glucose metabolism by Capito, K, Hansen, S E, Hedeskov, C J, Islin, H, Thams, P

“…Insulin secretion, insulin biosynthesis and islet glucose oxidation were studied in pancreatic islets isolated from fat-fed diabetic mice of both sexes…”
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An inhibitory role for polyamines in protein kinase C activation and insulin secretion in mouse pancreatic islets by Thams, P, Capito, K, Hedeskov, C J

“…The occurrence and function of polyamines in protein kinase C activation and insulin secretion in mouse pancreatic islets were studied. Determination of…”
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Production of [3H]choline-labelled metabolites from endogenously 3H-labelled phosphatidylcholine in mouse pancreatic islets by Capito, K, Hansen, S E, Thams, P

“…The involvement of phosphatidylcholine (PC) hydrolysis in the regulation of insulin secretion was studied in mouse pancreatic islets prelabelled with…”
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Stimulation by glucose of cyclic AMP accumulation in mouse pancreatic islets is mediated by protein kinase C by Thams, P, Capito, K, Hedeskov, C J

“…The mechanism of glucose-stimulated cyclic AMP accumulation in mouse pancreatic islets was studied. In the presence of 3-isobutyl-1-methylxanthine, both…”
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AKAP 18 α and γ have opposing effects on insulin release in INS-1E cells by Josefsen, Knud, Lee, Ying C., Thams, Peter, Efendic, Suad, Nielsen, Jens H.

“…A-kinase anchoring proteins (AKAPs) are known to compartmentalise protein kinase(s) to discrete cellular locations. Here we show that silencing of AKAP 18 α or…”
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Inositol phospholipid turnover in digitonin-permeabilised dispersed mouse pancreatic islet cells by Kardasz, A M, Capito, K, Thams, P, Hedeskov, C J

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Long-term fat-feeding-induced insulin resistance in normal NMRI mice: postreceptor changes of liver, muscle and adipose tissue metabolism resembling those of type 2 diabetes by Hedeskov, C J, Capito, K, Islin, H, Hansen, S E, Thams, P

“…Postreceptor insulin resistance was studied in liver, muscle and adipose tissue from NMRI mice of both sexes made diabetic by long-term fat-feeding…”
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Effect of diacylglycerol lipase inhibitor RHC 80267 on pancreatic mouse islet metabolism an insulin secretion by CAPITO, K, HANSEN, S. E, HEDESKOV, C. J, THAMS, P

“…The effect of interference with diacylglycerol metabolism was investigated in pancreatic mouse islets. In the presence of the diacylglycerol lipase inhibitor…”
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Glucose triggers protein kinase A-dependent insulin secretion in mouse pancreatic islets through activation of the K+ATP channel-dependent pathway by Thams, Peter, Anwar, Mohammad R, Capito, Kirsten

“…Objective: To assess the significance of protein kinase A (PKA) in glucose triggering of ATP-sensitive K+ (K+ATP) channel-dependent insulin secretion and in…”
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Phosphatidylinositol 4-Kinase Serves as a Metabolic Sensor and Regulates Priming of Secretory Granules in Pancreatic β Cells by Olsen, Hervør L., Høy, Marianne, Zhang, Wei, Bertorello, Alejandro M., Bokvist, Krister, Capito, Kirsten, Efanov, Alexander M., Meister, Björn, Thams, Peter, Yang, Shao-Nian, Rorsman, Patrik, Berggren, Per-Olof, Gromada, Jesper

“…Insulin secretion is controlled by the β cell's metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose…”
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Presence of ATP-pyrophosphohydrolase in mouse pancreatic islets by Capito, K., Hansen, S. E., Hedeskov, C. J., Thams, P.

“…Presence of ATP-pyrophosphohydrolase in mouse pancreatic islets. K Capito , S E Hansen , C J Hedeskov and P Thams Abstract The presence of an enzyme that…”
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Exogenous arachidonic acid inactivates protein kinase C in mouse pancreatic islets by Thams, P, Hedeskov, C J, Capito, K

“…The effect of arachidonic acid on protein kinase C activity and insulin secretion in mouse islets was investigated. Arachidonic acid stimulated protein kinase…”
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Polyamines in nerve terminals and secretory granules isolated from neurohypophyses by Krøigaard, M, Thams, P, Thorn, N A

“…In isolated nerve terminals from ox neurohypophyses the following concentrations of polyamines [pmol (microgram protein)-1 (mean +/- SEM)] were found:…”
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