Search Results - "THAMES, Howard D"
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Influence of Technologic Advances on Outcomes in Patients With Unresectable, Locally Advanced Non–Small-Cell Lung Cancer Receiving Concomitant Chemoradiotherapy
Published in International journal of radiation oncology, biology, physics (01-03-2010)“…Purpose In 2004, our institution began using four-dimensional computed tomography (4DCT) simulation and then intensity-modulated radiotherapy (IMRT)…”
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The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems
Published in PLoS computational biology (01-12-2016)“…We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of…”
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HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: Results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
Published in Radiotherapy and oncology (01-12-2014)“…Abstract Objective To investigate the impact of HPV status in patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received…”
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p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Published in Cancer research (Chicago, Ill.) (01-03-2022)“…Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that…”
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Estimation of α/β for Late Rectal Toxicity Based on RTOG 94-06
Published in International journal of radiation oncology, biology, physics (01-10-2011)“…Purpose To estimate α/β, the parameter ratio from the linear-quadratic (LQ) model, for Grade ≥2 late rectal toxicity among patients treated on Radiation…”
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Ultraviolet A does not induce melanomas in a Xiphophorus hybrid fish model
Published in Proceedings of the National Academy of Sciences - PNAS (18-05-2010)“…We examined the wavelength dependence of ultraviolet (UV) ra-diation (UVR)-induced melanoma in a Xiphophorus backcross hybrid model previously reported to be…”
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Computational Modeling of Micrometastatic Breast Cancer Radiation Dose Response
Published in International journal of radiation oncology, biology, physics (01-09-2016)“…Purpose Prophylactic cranial irradiation (PCI) involves giving radiation to the entire brain with the goals of reducing the incidence of brain metastasis and…”
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Rod Withers' Data are Available Online
Published in International journal of radiation oncology, biology, physics (01-02-2017)Get full text
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Late Rectal Toxicity on RTOG 94-06: Analysis Using a Mixture Lyman Model
Published in International journal of radiation oncology, biology, physics (15-11-2010)“…Purpose To estimate the parameters of the Lyman normal-tissue complication probability model using censored time-to-event data for Grade ≥2 late rectal…”
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Mitigation and Treatment of Radiation-Induced Thoracic Injury With a Cyclooxygenase-2 Inhibitor, Celecoxib
Published in International journal of radiation oncology, biology, physics (01-02-2013)“…Purpose To test whether a cyclooxygenase-2 inhibitor (celecoxib) could reduce mortality resulting from radiation-induced pneumonitis. Methods and Materials…”
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PSA nadir predicts biochemical and distant failures after external beam radiotherapy for prostate cancer: a multi-institutional analysis
Published in International journal of radiation oncology, biology, physics (15-03-2006)“…To determine the significance of prostate-specific antigen (PSA) nadir (nPSA) and the time to nPSA (T(nPSA)) in predicting biochemical or clinical disease-free…”
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Breast Conservation After Neoadjuvant Chemotherapy: The M.D. Anderson Cancer Center Experience
Published in Journal of clinical oncology (15-06-2004)“…To determine patterns of local-regional recurrence (LRR) and ipsilateral breast tumor recurrence (IBTR) among patients treated with breast conservation therapy…”
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Proton therapy toxicity outcomes for localized prostate cancer: Long-term results at a comprehensive cancer center
Published in Clinical and translational radiation oncology (01-09-2024)“…•Proton therapy is associated with low rates of late high grade genitourinary and gastrointensity toxicity for the treatment of localized prostate cancer.•Only…”
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Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy
Published in Radiotherapy and oncology (01-08-2006)“…The combination of molecular-targeted agents with irradiation is a highly promising avenue for cancer research and patient care. Molecular-targeted agents are…”
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Comparison of Treatment Tolerance and Outcomes in Patients With Cervical Cancer Treated With Concurrent Chemoradiotherapy in a Prospective Randomized Trial or With Standard Treatment
Published in International journal of radiation oncology, biology, physics (2008)“…Purpose To compare the treatment and outcomes of cervical cancer patients treated with concurrent chemoradiotherapy (CT-RT) in a multi-institutional trial or…”
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The Ratio of Positive to Excised Nodes Identifies High-risk Subsets and Reduces Inter-Institutional Differences in Locoregional Recurrence Risk Estimates in Breast Cancer Patients With 1–3 Positive Nodes: An Analysis of Prospective Data From British Columbia and the M. D. Anderson Cancer Center
Published in International journal of radiation oncology, biology, physics (01-05-2007)“…Purpose To examine the power of the nodal ratio (NR) of positive/excised nodes in predicting postmastectomy locoregional recurrence (LRR) in patients with 1–3…”
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The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis
Published in BMC cancer (22-09-2008)“…Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5)…”
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Comparison of rectal dose-wall histogram versus dose-volume histogram for modeling the incidence of late rectal bleeding after radiotherapy
Published in International journal of radiation oncology, biology, physics (01-12-2004)“…To compare the fits of normal-tissue complication probability (NTCP) models based on rectal dose-wall histograms (DWHs) vs. dose-volume histograms (DVHs) when…”
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Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation
Published in Radiotherapy and oncology (01-08-2005)“…Inhibition of repopulation and enhanced reoxygenation has been suggested to contribute to improvement of local tumour control after fractionated irradiation…”
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