Papillary adenoma of type II pneumocytes might have malignant potential

Papillary adenoma of type II pneumocytes might have malignant potential

Papillary adenoma of type II pneumocytes is a rare tumour. It is considered to be a benign neoplasm and is derived from immature cells in the bronchioloalveolar epithelium, however, its biological nature has not been elucidated. We report a case of an adenomatous tumour; a papillary adenoma of type...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology Vol. 428; no. 3; pp. 195 - 200
Main Authors: MORI, M, CHIBA, R, TEZUBKA, F, KAJI, M, KOBUBO, T, NUKIWA, T, TAKAHASHI, T
Format: Journal Article
Language:English
Published: Berlin Springer 01-06-1996
Subjects:
Adenoma - chemistry
Adenoma - pathology
Adult
Apoproteins - analysis
Aryl Hydrocarbon Hydroxylases
Biological and medical sciences
Carcinoembryonic Antigen - analysis
Cytochrome P-450 Enzyme System - analysis
Humans
Immunohistochemistry
Lung Neoplasms - chemistry
Lung Neoplasms - pathology
Male
Medical sciences
Microscopy, Electron
Pneumology
Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactants - analysis
Steroid Hydroxylases - analysis
Tumors of the respiratory system and mediastinum
Human
Immunohistochemistry
Lung disease
Pneumocyte
Respiratory disease
Cytochrome P450
Malignant tumor
Adenoma
Potential
Bronchopulmonary
Case study
Pathology
Carcinoembryonic antigen
Papillary adenoma
Immunological investigation
Malignant transformation
Bronchus disease
Benign neoplasm
Immaturity
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Description
Summary:Papillary adenoma of type II pneumocytes is a rare tumour. It is considered to be a benign neoplasm and is derived from immature cells in the bronchioloalveolar epithelium, however, its biological nature has not been elucidated. We report a case of an adenomatous tumour; a papillary adenoma of type II pneumocytes, which we regard as possessing malignant potential. Light microscopically, as well circumscribed, papillary tumour of predominantly cuboidal cells resembling type II pneumocytes was found, but Clara type and ciliated cells were also present. Immunohistochemically, the tumour cells reacted positively with antibodies to surfactant apoproteins (A, B), carcinoembryonic antigen, cytochrome P-450 1A1-2 and 2B1-2. Ultrastructurally, many osmiophilic lamellar bodies and electron-dense granules were demonstrated. Semi-serial sections revealed signs of transbronchial dissemination and vascular invasion. Morphometry using 12-dimensional cluster analysis disclosed features of the tumour cells which resembled those of pneumocyte type II adenocarcinoma. These findings suggest that the present case has some malignant characteristics and originates from immature bronchiolar or alveolar cells, with a potential to develop into both type II pneumocyte and Clara cell type adenocarcinomas.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:0945-6317
1432-2307
DOI:10.1007/bf00200662