Search Results - "TEW, David G"

Lipoprotein-Associated Phospholipase A2, Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions by Häkkinen, Tomi, Luoma, Jukka S, Hiltunen, Mikko O, Macphee, Colin H, Milliner, Kevin J, Patel, Lisa, Rice, Simon Q, Tew, David G, Karkola, Kari, Ylä-Herttuala, NA

“…We studied the expression of lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme capable of hydrolyzing platelet-activating factor (PAF), PAF-like…”
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Determination of phosphate in nanomolar range by an enzyme-coupling fluorescent method by Vazquez, Maria J, Rodriguez, Beatriz, Zapatero, Cleofe, Tew, David G

“…We have successfully configured a new ultrasensitive fluorescent phosphate assay that detects free phosphate in solution through the formation of the…”
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Steady-State Kinetic Characterization of Substrates and Metal-Ion Specificities of the Full-Length and N-Terminally Truncated Recombinant Human Methionine Aminopeptidases (Type 2) by Yang, Guang, Kirkpatrick, Robert B, Ho, Thau, Zhang, Gui-Feng, Liang, Po-Huang, Johanson, Kyung O, Casper, David J, Doyle, Michael L, Marino, Joseph P, Thompson, Scott K, Chen, Wenfang, Tew, David G, Meek, Thomas D

“…The steady-state kinetics of a full-length and truncated form of the type 2 human methionine aminopeptidase (hMetAP2) were analyzed by continuous monitoring of…”
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Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications by Tew, David G

“…Diphenyliodonium has been shown to be an irreversible, time-dependent inhibitor of NADPH cytochrome P450 oxidoreductase (EC 1.6.2.4) with the Ki for…”
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Purification, Properties, Sequencing, and Cloning of a Lipoprotein-Associated, Serine-Dependent Phospholipase Involved in the Oxidative Modification of Low-Density Lipoproteins by Tew, David G, Southan, Christopher, Rice, Simon Q.J, Li, Haodong, Boyd, Helen F, Moores, Kitty, Gloger, Israel S, Macphee, Colin H

“…A novel LDL-associated phospholipase A2 (LDL-PLA2) has been purified to homogeneity from human LDL obtained from plasma apheresis. This enzyme has activity…”
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Highly Potent Inhibitors of Methionine Aminopeptidase-2 Based on a 1,2,4-Triazole Pharmacophore by Marino, Joseph P, Fisher, Paul W, Hofmann, Glenn A, Kirkpatrick, Robert B, Janson, Cheryl A, Johnson, Randall K, Ma, Chun, Mattern, Michael, Meek, Thomas D, Ryan, M. Dominic, Schulz, Christina, Smith, Ward W, Tew, David G, Tomazek, Thaddeus A, Veber, Daniel F, Xiong, Wenfang C, Yamamoto, Yuuichi, Yamashita, Keizo, Yang, Guang, Thompson, Scott K

“…High-throughput screening for inhibitors of the human metalloprotease, methionine aminopeptidase-2 (MetAP2), identified a potent class of…”
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Mechanism of Inhibition of Cathepsin K by Potent, Selective 1,5-Diacylcarbohydrazides:  A New Class of Mechanism-Based Inhibitors of Thiol Proteases by Bossard, Mary J, Tomaszek, Thaddeus A, Levy, Mark A, Ijames, Carl F, Huddleston, Michael J, Briand, Jacques, Thompson, Scott, Halpert, Stacie, Veber, Daniel F, Carr, Steven A, Meek, Thomas D, Tew, David G

“…The nature of the inhibition of thiol proteases by a new class of mechanism-based inhibitors, 1,5-diacylcarbohydrazides, is described. These potent,…”
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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor by MacPhee, C H, Moores, K E, Boyd, H F, Dhanak, D, Ife, R J, Leach, C A, Leake, D S, Milliner, K J, Patterson, R A, Suckling, K E, Tew, D G, Hickey, D M

“…A novel and potent azetidinone inhibitor of the lipoprotein-associated phospholipase A2 (Lp-PLA2), i.e. platelet-activating factor acetylhydrolase, is…”
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Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents by GARNER, A. P, PAINE, M. J. I, RODRIGUEZ-CRESPO, I, CHINJE, E. C, ORTIZ DE MONTELLANO, P, STRATFORD, I. J, TEW, D. G, WOLF, C. R

“…Nitric oxide synthases (NOSs) play a crucial role in the control of blood flow, memory formation, and the immune response. These proteins can be structurally…”
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Cloning and Characterization of a Novel Human Dual Flavin Reductase by Paine, Mark J.I., Garner, Andrew P., Powell, David, Sibbald, Jennifer, Sales, Mark, Pratt, Norman, Smith, Trudi, Tew, David G., Wolf, C.Roland

“…Flavoprotein reductases play a key role in electron transfer in many physiological processes. We have isolated a cDNA with strong sequence similarities to…”
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Dissection of NADPH-Cytochrome P450 Oxidoreductase into Distinct Functional Domains by Graeme C. M. Smith, Tew, David G., Wolf, C. Roland

“…NADPH-cytochrome P450 oxidoreductase transfers electrons from NADPH to cytochrome P450 and catalyzes the one-electron reduction of many drugs and foreign…”
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Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones by Jarvest, Richard L., Pinto, Ivan L., Ashman, Stephen M., Dabrowski, Christine E., Fernandez, Annabellee V., Jennings, L.John, Lavery, Patrick, Tew, David G.

“…Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency…”
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Identification, Genomic Organization, and mRNA Expression of LACTB, Encoding a Serine β-Lactamase-like Protein with an Amino-terminal Transmembrane Domain by Smith, Trudi S., Southan, Christopher, Ellington, Kathryn, Campbell, David, Tew, David G., Debouck, Christine

“…Database searching with bacterial serine β-lactamases identified mouse expressed sequence tags (ESTs) with significant similarity scores.The cloned mouse cDNA…”
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Mechanism of Inhibition of LDL Phospholipase A2 by Monocyclic-β-lactams. Burst Kinetics and the Effect of Stereochemistry by Tew, David G, Boyd, Helen F, Ashman, Stephen, Theobald, Colin, Leach, Colin A

“…Investigation of the inhibition of LDL-associated phospholipase A2 by monocyclic β-lactams has shown that LDL phospholipase A2 is capable of hydrolyzing…”
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Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor by Rice, S Q, Southan, C, Boyd, H F, Terrett, J A, MacPhee, C H, Moores, K, Gloger, I S, Tew, D G

“…Using expressed sequence tag (EST) homology screening, a new human serine dependent phospholipase A2 (HSD-PLA2) was identified that has 40% amino acid identity…”
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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2 by BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L

“…From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human…”
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Structure-based design of non-peptide, carbohydrazide-based cathepsin K inhibitors by Thompson, Scott K, Halbert, Stacie M, DesJarlais, Renee L, Tomaszek, Thaddeus A, Levy, Mark A, Tew, David G, Ijames, Carl F, Veber, Daniel F

“…Using binding models which were based on the X-ray crystal structure of an amino acid-based active site-spanning inhibitor complexed with cathepsin K,…”
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Structure-Based Design of Cathepsin K Inhibitors Containing a Benzyloxy-Substituted Benzoyl Peptidomimetic by Thompson, Scott K, Smith, Ward W, Zhao, Baoguang, Halbert, Stacie M, Tomaszek, Thaddeus A, Tew, David G, Levy, Mark A, Janson, Cheryl A, D‘Alessio, Karla J, McQueney, Michael S, Kurdyla, Jeff, Jones, Christopher S, DesJarlais, Renee L, Abdel-Meguid, Sherin S, Veber, Daniel F

“…Peptidomimetic cathepsin K inhibitors have been designed using binding models which were based on the X-ray crystal structure of an amino acid-based, active…”
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Lipoprotein-associated PLA2 inhibition : a novel, non-lipid lowering strategy for atherosclerosis therapy by LEACH, Colin A, HICKEY, Deirdre M. B, IFE, Robert J, MACPHEE, Colin H, SMITH, Stephen A, TEW, David G

“…Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a serine lipase that is associated with low density lipoprotein (LDL) in human plasma. Substrates include…”
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Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility by Douthwaite, Julie A., Brown, Christopher A., Ferdinand, John R., Sharma, Rahul, Elliott, Jane, Taylor, Molly A., Malintan, Nancy T., Duvoisin, Hannah, Hill, Thomas, Delpuech, Oona, Orton, Alexandra L., Pitt, Haidee, Kuenzi, Fred, Fish, Simon, Nicholls, David J., Cuthbert, Anna, Richards, Ian, Ratcliffe, Giles, Upadhyay, Abhishek, Marklew, Abigail, Hewitt, Craig, Ross-Thriepland, Douglas, Brankin, Christopher, Chodorge, Matthieu, Browne, Gareth, Mander, Palwinder K., DeWildt, Ruud M., Weaver, Shane, Smee, Penny A., van Kempen, Joost, Bartlett, Jon G., Allen, Paula M., Koppe, Emma L., Ashby, Charlotte A., Phipps, Julian D., Mehta, Nalini, Brierley, David J., Tew, David G., Leveridge, Melanie V., Baddeley, Stuart M., Goodfellow, Ian G., Green, Clive, Abell, Chris, Neely, Andy, Waddell, Ian, Rees, Steve, Maxwell, Patrick H., Pangalos, Menelas N., Howes, Rob, Clark, Roger

“…On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of…”
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